Results 81 to 90 of about 1,638 (164)

Occurrence and spread of carbapenemase‐producing Enterobacterales (CPE) in the food chain in the EU/EFTA. Part 1: 2025 update

EFSA Journal, Volume 23, Issue 4, April 2025.
Abstract Carbapenemase‐producing Enterobacterales (CPE) have been reported in the food chain in 14 out of 30 EU/EFTA countries. Commonly reported genes are blaVIM‐1, blaOXA‐48 and blaOXA‐181, followed by blaNDM‐5 and blaIMI‐1. Escherichia coli, target of most of the studies, Enterobacter cloacae complex, Klebsiella pneumoniae complex and Salmonella ...
EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), Ana Allende, Avelino Álvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Lieve Herman, Liesbeth Jacxsens, Lapo Mughini‐Gras, Maarten Nauta, Jakob Ottoson, Fernando Pérez‐Rodríguez, Panagiotis Skandamis, Elisabetta Suffredini, Hector Argüello, Johan Bengtsson‐Palme, Alessandra Carattoli, Anke Kohlenberg, Dominique L. Monnet, Laurent Poirel, Beatriz Guerra, Raquel García‐Fierro, Ernesto Liébana, Sonagnon Martin Goudjihounde, Núria Ferrer‐Bustins, Hanne Rabbås, Luisa Peixe   +28 more
wiley   +1 more source

DNA Polymerase IV dinB Favors the Adaptive Fitness of mcr‐carrying Bacteria Through a Negative Feedback Regulatory Mechanism

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This work demonstrates that DNA polymerase IV dinB favors the adaptive fitness of mcr‐carrying bacteria via a negative feedback regulatory mechanism. Specifically, the elevation of ROS production by intact mcr activates dinB, which in turn represses the mcr expression, maintaining a balance between colistin resistance and bacterial fitness.
Haijie Zhang, Xia Xiao, Chenlong Wang, Yurong Zhao, Bo Chen, Xinyuan Ji, Lina Gu, Jie Wang, Zhiqiang Wang, Yuan Liu   +9 more
wiley   +1 more source

Mutational change of CTX‐M‐15 to CTX‐M‐127 resulting in mecillinam resistant Escherichia coli during pivmecillinam treatment of a patient

MicrobiologyOpen, Volume 8, Issue 12, December 2019., 2019
In this study, we investigated the genetics behind mecillinam resistance which occurred in an extended‐spectrum β‐lactamase‐producing Escherichia coli during pivmecillinam treatment of a patient. The genomic comparison of the two isolates points toward a mutational change of blaCTX‐M‐15 into blaCTX‐M‐127 along with a serotype shift from rough to full ...
Karen Leth Nielsen, Katrine Hartung Hansen, Jesper Boye Nielsen, Jenny Dahl Knudsen, Kristian Schønning, Niels Frimodt‐Møller, Frederik Boëtius Hertz, Filip Jansåker   +7 more
wiley   +1 more source

Emergence and Genomic Features of a mcr-1 Escherichia coli from Duck in Hungary

Antibiotics, 2023
Plasmids carrying high-risk resistance mechanisms in pathogenic E. coli have gained particular attention in veterinary medicine, especially since the discovery of the colistin resistance gene, mcr-1.
Ama Szmolka, Ákos Gellért, Dóra Szemerits, Fanni Rapcsák, Sándor Spisák, András Adorján   +5 more
doaj   +1 more source

Genome stability during serial sub-culturing in hyperepidemic multidrug-resistant Klebsiella pneumoniae and Escherichia coli. [PDF]

, 2022
BACKGROUND Core-genome single-nucleotide variant (cgSNV) analysis represents a powerful tool for epidemiological investigations of multidrug-resistant (MDR) bacteria.
Campos-Madueno, Edgar I, Endimiani, Andrea, Moser, Aline I, Perreten, Vincent   +3 more
core   +2 more sources

Integrated Genomic and Phenotypic Characterization of an Mcr-10.1‐Harboring Multidrug Resistant Escherichia coli Strain From Migratory Birds in China

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Background: The global rise in antibiotic resistance among multidrug resistant (MDR) Gram‐negative (GN) bacteria has posed significant health challenges, leading to the resurgence of colistin as a key defense against these bacteria. However, the widespread use of colistin has resulted in the rapid emergence of colistin resistance on a global scale. Ten
Ronglei Huang, Xue Ji, Bing Liang, Bowen Jiang, Danhong Wang, Yi Tang, Chengyang Zhang, Ang Zhou, Nan Li, Chongtao Du, Yang Sun, Zongfu Wu   +11 more
wiley   +1 more source

Genomic characterization of multidrug-resistance gene cfr in Escherichia coli recovered from food animals in Eastern China

Frontiers in Microbiology, 2022
The plasmid-borne cfr gene, mediating multiple drug resistance (MDR), has been observed in many Gram-positive bacteria. The prevalence of cfr and its co-occurrence with additional antimicrobial resistance (AMR) determinants in Escherichia coli is an ...
Biao Tang, Juan Ni, Juan Ni, Jiahui Lin, Yangying Sun, Hui Lin, Yuehong Wu, Hua Yang, Min Yue, Min Yue   +9 more
doaj   +1 more source

Whole genome sequencing,molecular typing and in vivovirulence of OXA-48-producingEscherichia coli isolates includingST131 H30-Rx, H22 and H41subclones [PDF]

, 2017
Carbapenem-resistant Enterobacteriaceae, including the increasingly reported OXA-48 Escherichia coli producers, are an emerging public health threat worldwide.
A Carattoli, A Carattoli, A Carrër, A Mora, A Potron, AHAM Hoek van, DR Zerbino, E Zankari, F Tanfous Ben, G Dahbi, G Gerhold, G Peirano, GC Cerqueira, J Blanco, J Fernández, J Fernández, JF Turton, JR Johnson, JR Johnson, K Power, KG Joensen, KG Joensen, L Chen, L Poirel, L Poirel, LW Riley, M Golebiewski, M-H Nicolas-Chanoine, MP Garcillán-Barcia, MV Larsen, N Stoesser, N-F Alikhan, NK Petty, O Clermont, O Clermont, P Nordmann, PL Ho, R Beyrouthy, R Beyrouthy, RR Spurbeck, S Ktari, SJ Weissman, SK Gupta, T Giani, T Wirth, TJ Johnson, VF Lanza, X Liu   +47 more
core   +7 more sources

Occurrence of mcr-1 and mcr-2 colistin resistance genes in porcine Escherichia coli isolates (2010–2020) and genomic characterization of mcr-2-positive E. coli [PDF]

, 2022
Introduction: The global emergence of plasmid-mediated colistin resistance is threatening the efficacy of colistin as one of the last treatment options against multi-drug resistant Gram-negative bacteria.
Bauerfeind, Rolf, Ewers, Christa, Göpel, Lisa, Kerner, Katharina, Prenger-Berninghoff, Ellen, Semmler, Torsten   +5 more
core   +2 more sources

Compensatory evolution of chromosomes and plasmids counteracts the plasmid fitness cost

Ecology and Evolution, Volume 14, Issue 8, August 2024.
In this review, we provide a comprehensive overview of the currently reported mechanisms underlying compensatory evolution on chromosomes and plasmids, elucidate key targets regulating plasmid fitness cost, and discuss future challenges in this field.
Ziyi Liu, Qiuyun Zhao, Chenggang Xu, Houhui Song   +3 more
wiley   +1 more source