Results 1 to 10 of about 4,853 (196)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation [PDF]

Advanced Science
Many plant‐derived bioactive molecules with low solubility and permeability can cause hepatocyte injury. However, the mechanism by which they induce hepatic damage without passive diffusion into the hepatic circulatory system remains unclear.
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
doaj   +3 more sources

An Indirubin Derivative, Indirubin-39-MonoximeSuppresses Oral Cancer Tumorigenesis through theDownregulation of Survivin [PDF]

PLoS ONE, 2013
Oral cancer is the fourth most common cause of death from cancer in Taiwanese men. Indirubin-3′-monoxime (I3M), a potent cyclin-dependent kinase inhibitor, has therapeutic effects in other cancer cells.
Nai-Wen Chang, Wan-Yu Lo
core   +15 more sources

Exploring of therapeutic potential of indirubin-loaded nanofibrous scaffolds for localized melanoma treatment [PDF]

Journal of Biological Engineering
Nanofibrous scaffolds have been established as capable platforms for localized drug delivery systems of skin cancer management. Our study aimed to develop an electrospun nanofibrous scaffold loaded with indirubin, a naturally occurring bisindole alkaloid
Sajad Rahimi, Kamyar Khoshnevisan, Amir Hossein Izadi Nazar, Maryam Doostan, Hassan Maleki   +4 more
doaj   +2 more sources

A Scalable and Sustainable Synthesis of Indirubin Frameworks Enabled by Deep Eutectic Solvents. [PDF]

ChemSusChem
A sustainable protocol for the synthesis of indirubin in a choline chloride/urea deep eutectic solvent at 70°C under air affords the product in 70% yield without chromatography. The method is robust, scalable to pilot scale, and enables late‐stage functionalization, granting access to a wide range of indirubin derivatives. CHEM21 green metrics validate
Delvecchio B, Cicco L, Paparella AN, Di Salvo G, Perna FM, Capriati V.   +5 more
europepmc   +2 more sources

Evaluation of Indigo Naturalis Prepared Using a Novel Method: Anti-Inflammatory Activities Against Colonic Cancer Cell Lines. [PDF]

Mediators Inflamm
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), and cancerous transformation of UC is closely associated with chronic inflammation of colonic tissues. Indigo naturalis (IN) prepared using a novel method (NIN) has exhibited beneficial efficacy against inflammatory and cancerous colonic cells.
Xu X, Lin L, Ning W, Zhou X, Ullah A, Huang X, Yang H, Wu X, Diao Y.   +8 more
europepmc   +2 more sources

Indirubin attenuates sepsis by targeting the EGFR/SRC/PI3K and NF-κB/MAPK signaling pathways in macrophages [PDF]

Frontiers in Pharmacology
BackgroundIsatidis Folium, a botanical drug widely used in traditional medicine, is known for its anti-inflammatory properties, including heat-clearing, detoxifying, and blood-cooling effects. Although its potential in sepsis treatment has been suggested,
Yancen Li, Chengyu Wan, Fan Li, Guang Xin, Tao Wang, Qilong Zhou, Tingyu Wen, Shiyi Li, Xiaoting Chen, Wen Huang   +9 more
doaj   +2 more sources

Indirubin as a red hair Colourant from Indigofera tinctoria L. [PDF]

Int J Cosmet Sci
An immediate stable red colour result after application of Indigofera tinctoria L. on hair in the presence of isatin and a reducing agent was achieved. A revised indigo molecule and indirubin synthesis pathway for I. tinctoria L. application including the effect of said additives to the colour outcome is presented.
Klaas S, Vill V, Straske F.
europepmc   +2 more sources

Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy [PDF]

Scientific Reports
This study investigated the effects of indirubin on autophagy and apoptosis in cervical cancer models, with a focus on elucidating the underlying molecular mechanisms.
Xiuchao Xie, Chang Liu, Xiaoling Liu, Lin Hou, Ya Zhang, Lin Huang, Weidong Peng, Yu Liu   +7 more
doaj   +2 more sources

The mechanism of indigo naturalis and its active ingredients against ulcerative colitis [PDF]

Scientific Reports
Indigo Naturalis (IN), utilized for thousands of years in China, is known for its effects in clearing heat, removing toxins, and alleviating diarrhea. Studies indicate that IN possesses anti-ulcerative colitis (UC) effects.
Ke-Yu Ma, Bao-Long Hou, An-Qi Fan, An-Li Huang, Bo-Rui Li, Yan-Ni Liang, Zheng Wang   +6 more
doaj   +2 more sources

Combining Network Pharmacology, Molecular Docking and Experimental Validation to Explore the Effects and Mechanisms of Indirubin on Acute Lymphoblastic Leukemia [PDF]

Drug Design, Development and Therapy
Lu Jin,1,2 Yunshuang Guan,3 Xue Li,3,4 Mingyue Wang,2 Ying Shen,1,2 Nianxue Wang,3 Zhixu He1,2,5 1Department of Pediatrics, School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 2Department of Pediatric ...
Jin L, Guan Y, Li X, Wang M, Shen Y, Wang N, He Z   +6 more
doaj   +1 more source