Design, Synthesis, and Cytotoxicity Evaluation of Novel Indolin-2-One Based Molecules on Hepatocellular Carcinoma HepG2 Cells as Protein Kinase Inhibitors [PDF]
MoleculesA series of indolinone-based derivatives were designed and synthesized using the hybrid pharmacophoric design approach as cytotoxic kinase inhibitors.
Manal M. Kandeel +4 more
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N-Glycosides of indigo, indirubin, and isoindigo: blue, red, and yellow sugars and their cancerostatic activity [PDF]
Beilstein Journal of Organic ChemistryIndigo, indirubin, and isoindigo derivatives have been used for centuries as pigments. Since the 1990s, a new aspect of the chemistry of this type of compounds is their activity against various types of cancer.
Peter Langer
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Indirubin alleviates CCl4-induced liver fibrosis by regulation of TGF-β-mediated signaling pathways [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Liver fibrosis is a common liver disease caused by chronic liver damage. However, there are currently no approved drugs available to treat it. Therefore, the therapeutic effect of indirubin on liver fibrosis was evaluated.
Xiaoying Li, Yuanzhi Yao, Lin Wei
doaj +1 more source
Mapping of Some Further Alkylation-Initiated Pathways to Polyheterocyclic Compounds from Indigo and Indirubin [PDF]
MoleculesThe reaction of indigo with two equivalents of the electrophile ethyl bromoacetate with caesium carbonate as a base result in the formation of structurally complex polyheterocyclics, including a fused spiroimidazole and a spiro[1,3]oxazino derivative ...
Sarfaraz Ali +6 more
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Advances in microbial biosynthesis of indirubin. [PDF]
Chin Herb MedLi K +8 more
europepmc +2 more sources
Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases [PDF]
Evidence-Based Complementary and Alternative Medicine, 2015 Indirubin is the active component of Danggui Longhui Wan, a traditional Chinese medicine formulation. The encouraging clinical results from the 1980s obtained in chronic myelocytic leukemia patients treated with indirubin stimulated numerous studies on this compound.
Blazevic, Tina +5 more
openaire +4 more sources
Indirubin Increases CD4+CD25+Foxp3+ Regulatory T Cells to Prevent Immune Thrombocytopenia in Mice. [PDF]
PLoS ONE, 2015 Indirubin, a traditional Chinese medicine, is used to treat autoimmune diseases in clinics. However, the effects of indirubin on the immunosuppressive CD4+CD25+Foxp3+ regulatory T cells (Treg) have not been addressed.
Aijun Zhang +4 more
doaj +1 more source
Applied Sciences, 2021 Indigo naturalis, which is extracted from the leaves and branches of Baphicacanthus cusia (Nees) Bremek, has traditionally been used to treat psoriasis.
Ly Thi Huong Nguyen +4 more
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Frontiers in Immunology, 2022 ObjectiveTo investigate the efficacy of indirubin combined with human umbilical cord mesenchymal stem cells (hUC-MSCs) in the treatment of psoriatic lesions in BALB/c mice and to explore the related mechanism of indirubin in the treatment of psoriasis ...
XiaoJuan Lu +8 more
doaj +1 more source
Indirubin inhibits Wnt/β-catenin signal pathway via promoter demethylation of WIF-1
BMC Complementary Medicine and Therapies, 2020 Background Psoriasis is a common inflammatory skin disease. Abnormal proliferation of keratinocytes is one of the psoriatic histopathological features.
Shou Gang Liu +3 more
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