Results 21 to 30 of about 4,853 (196)
Frontiers in Pharmacology, 2021 Background: Clinical trials have proven that indigo naturalis is a candidate drug for treating ulcerative colitis (UC), but its therapeutic mechanism is still unclear.Purpose: This study aimed to evaluate the protective effect and mechanism of indigo ...
Qi-yue Yang +6 more
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Characterization of anti-leukemia components from Indigo naturalis using comprehensive two-dimensional K562/cell membrane chromatography and in silico target identification. [PDF]
, 2016 Traditional Chinese Medicine (TCM) has been developed for thousands of years and has formed an integrated theoretical system based on a large amount of clinical practice.
Cao, Yan +9 more
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Effect of indirubin on the expression of proinflammatory cytokines in keratinocytes
Pifu-xingbing zhenliaoxue zazhi, 2021 Objective: To investigate the effect of indirubin on the expression of proinflammatory cytokines in HaCaT cells, and to elucidate the mechanisms of Diqing ointment in the treatment of psoriasis.
Qingwen LI +3 more
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Indirubin derivative E804 inhibits angiogenesis [PDF]
BMC Cancer, 2012 It has previously been shown that indirubin derivative E804 (IDR-E804) blocks signal transducer and activator of transcription-3 signaling in human breast and prostate cancer cells and inhibits Src kinase activity. To further establish its role in angiogenesis, we tested its potential using human umbilical vein endothelial cells (HUVECs) and analyzed ...
Shin, Eun-Kyung, Kim, Jin-Kyung
openaire +4 more sources
Indirubin exerts anticancer effects on human glioma cells by inducing apoptosis and autophagy
AMB Express, 2020 Glioma causes significant mortality across the world and the most aggressive type of brain cancer. The incidence of glioma is believed to increase in the next few decades and hence more efficient treatment strategies need to be developed for management ...
Zhaohui Li +4 more
doaj +1 more source
Molecules, 2022 Aryl hydrocarbon receptor (AhR) activation by environmental agents and microbial metabolites is potentially implicated in a series of skin diseases. Hence, it would be very important to identify natural compounds that could inhibit the AhR activation by ...
Panagiotis Kallimanis +6 more
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Indirubin Derivative 6BIO Suppresses Metastasis [PDF]
Cancer Research, 2013 Abstract While metastasis is the chief cause of cancer mortality, there nonetheless remains a lack of antimetastatic therapies that are clinically available. In this study, we present the indirubin derivative 6-bromo-indirubin-3′-oxime (6BIO) as a promising antimetastatic agent.
Simone, Braig +6 more
openaire +2 more sources
Neural Regeneration Research, 2016 Indirubin-3′-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer′s disease.
Shu-gang Zhang +8 more
doaj +1 more source
Impairment of the autophagic flux in astrocytes intoxicated by trimethyltin [PDF]
, 2015 Autophagy is a lysosomal catabolic route for protein aggregates and damaged organelles which in different stress conditions, such as starvation, generally improves cell survival.
Catizone, Angiolina +8 more
core +2 more sources
Antioxidants, 2021 Efficient drugs are needed for countering the worldwide high incidence of cutaneous squamous cell carcinoma (cSCC) and actinic keratosis. Indirubin derivatives represent promising candidates, but their effects in cSCC cells have not been reported before.
Jiaqi Zhu +3 more
doaj +1 more source