Results 31 to 40 of about 4,853 (196)
A Mixed Micellar Formulation for the Transdermal Delivery of an Indirubin Analog
Pharmaceutics, 2020 Indirubin is an active component of Dang Gui Long Hui Wan, which has been used in traditional Chinese medicine to treat inflammatory diseases as well as for the prevention and treatment of human cancer, such as chronic myeloid leukemia.
Seol Hwa Seo +6 more
doaj +1 more source
Bioresources and Bioprocessing, 2022 Indirubin is a bisindole compound for the treatment of chronic myelocytic leukemia. Here, we presented a structure-guided method to improve the activity of a flavin-containing monooxygenase (bFMO) for the efficient production of indirubin in Escherichia ...
Bing-Yao Sun +10 more
doaj +1 more source
Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context [PDF]
, 2012 The aryl hydrocarbon receptor (AhR) mediates the induction of a variety of xenobiotic metabolism genes. Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands ...
BALBONI, GIANFRANCO +10 more
core +1 more source
Genome-Scale Promoter Engineering by Coselection MAGE [PDF]
, 2012 Multiplex Automated Genome Engineering (MAGE) employs short oligonucleotides to scarlessly modify genomes. However, insertions of >10 bases are still inefficient, but can be improved substantially by selection of highly modified chromosomes.
Bang, Duhee +5 more
core +1 more source
Nutrition & Metabolism, 2020 Background Obesity occurs when the body’s energy intake is constantly greater than its energy consumption and the pharmacological enhancing the activity of brown adipose tissue (BAT) and (or) browning of white adipose tissue (WAT) has been considered ...
Gang Wei +5 more
doaj +1 more source
Anti-inflammatory effects of indirubin derivatives on influenza A virus-infected human pulmonary microvascular endothelial cells [PDF]
, 2016 Influenza A virus (IAV) poses global threats to human health. Acute respiratory distress syndrome and multi-organ dysfunction are major complications in patients with severe influenza infection.
Chan, MCW +7 more
core +1 more source
Biotechnological applications of functional metagenomics in the food and pharmaceutical industries [PDF]
, 2015 peer-reviewedMicroorganisms are found throughout nature, thriving in a vast range of environmental conditions. The majority of them are unculturable or difficult to culture by traditional methods.
Alvarez-Ordonez, Avelino +3 more
core +1 more source
Antimicrobial, antimycobacterial and antibiofilm properties of Couroupita guianensis Aubl. fruit extract [PDF]
, 2012 BACKGROUND: Couroupita guianensis Aubl. (Lecythidaceae) is commonly called Ayahuma and the Cannonball tree. It is distributed in the tropical regions of northern South America and Southern Caribbean. It has several medicinal properties.
Chandrasekar Balachandran +7 more
core +1 more source
Photoreactivity of indirubin derivatives
Photochemical & Photobiological Sciences, 2008 Twenty-nine analogs of indirubin, an isomer of indigo, have been synthesized to optimize its promising kinase inhibitory scaffold. These compounds being also pigmented, have been tested for their photoreactivity. Absorption maxima were between 485 nm and 560 nm.
Olivier, D. +11 more
openaire +3 more sources
Pharmacological properties of indirubin and its derivatives
Biomedicine & Pharmacotherapy, 2022 Indirubin is the main bioactive component of the traditional Chinese medicine Indigo naturalis and is a bisindole alkaloid. Multiple studies have shown that indirubin exhibits good anticancer, anti-inflammatory and neuroprotective properties.The purpose of this review is to provide a summary of the pharmacological mechanisms of indirubin and its ...
Lin, Yang +4 more
openaire +2 more sources