Cell migration in paediatric glioma; characterisation and potential therapeutic targeting [PDF]
, 2015 Background: Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressive brain tumours. Their invasive phenotype contributes to their limited therapeutic response, and novel treatments that block brain tumour ...
A Broniscer +36 more
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International Journal of Secondary Metabolite, 2019 Tryptantrin and indirubin are pharmacologically active compounds used in treatment of disseases such as cancer and Alzheimer's. In this study, we investigated the influences of different concentrations of methyl jasmonate (MeJa) and putrescine (Put) on ...
Özgür Karakaş
doaj +1 more source
Lithium limits trimethyltin-induced cytotoxicity and proinflammatory response in microglia without affecting the concurrent autophagy impairment [PDF]
, 2016 Trimethyltin (TMT) is a highly toxic molecule present as an environmental contaminant causing neurodegeneration particularly of the limbic system both in humans and in rodents.
Artico, Marco +8 more
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Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis [PDF]
, 2013 Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine.
Endo Shinji +14 more
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An updated review on Couroupita guianensis Aubl: a sacred plant of India with myriad medicinal properties [PDF]
Journal of HerbMed Pharmacology, 2020 From ancient times, medicinal plants have been making important contributions to mankind owing to their healing properties. Their fundamental aspects such as safety, quality, and efficiency ensure the role of plant-based medicines in healthcare ...
Lawrence Anna Sheba +1 more
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Journal of Chemistry, 2023 CuSO4/hydrazine hydrate was used as a catalyst system for copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) of AZT and 5′-azido adenosine with terminal alkynes to give 30 novel 1,2,3-triazole derivatives.
Duc Anh Le +12 more
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Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
Frontiers in Cellular Neuroscience, 2022 Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform ...
Keunjung Heo +11 more
doaj +1 more source
T cell immune abnormalities in immune thrombocytopenia [PDF]
, 2014 Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of
Jun Peng +3 more
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Acid‐ and Nucleophile‐Gated Photoisomerization of Phosphaindirubin
Angewandte Chemie International Edition, EarlyView.Triply gated isomerization: In polar solvents, a phosphorus‐containing indirubin photoswitch undergoes visible‐light‐driven Z→E isomerization only when protonated, and reverts thermally via nucleophile‐catalyzed back‐isomerization. This three‐way control by light, acid, and nucleophile enables reversible photoisomerization.
Jacob Jan van der Wal +8 more
wiley +1 more source
Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers [PDF]
, 2017 Aryl hydrocarbon receptor (AHR) is the key transcription factor that controls animal development and various adaptive processes. The AHR\u27s target genes are involved in biodegradation of endogenous and exogenous toxins, regulation of immune response ...
Akishina, Angelina A. +11 more
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