Results 81 to 90 of about 4,853 (196)
Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway
Drug Design, Development and Therapy, 2018 Lihong Chen, Jinhua Wang, Jianbo Wu, Qiaomei Zheng, Jifen Hu Department of Obstetrics and Gynecology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China Background: Indirubin is the active component of Danggui Longhui Wan, a ...
Chen L, Wang J, Wu J, Zheng Q, Hu J
doaj
ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of bax translocation in HeLa cells [PDF]
, 2009 Extracellular signal-regulated kinase (ERK) 1/2 signaling is involved in tumor cell survival through the regulation of Bcl-2 family members. To explore this further and to demonstrate the central role of the mitochondria in the ERK1/2 pathway we used the
Aventaggiato, Michele +10 more
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Advanced Science, Volume 12, Issue 42, November 13, 2025.1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin +11 more
wiley +1 more source
A case study - Regulation and Functional Mechanisms of Cancer Cells and Control its Activity Using Plants and their Derivatives [PDF]
, 2013 Novel exploiting to the understanding of conventional medicine was followed by the findings of many unique secondary metabolites and its biological property and is highly required for treating of many endemic diseases.
Gaanty Pragas, Maniam +3 more
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Cancer Medicine, Volume 14, Issue 21, November 2025.ABSTRACT Hematological malignancies are complex clonal disorders that pose a significant threat to human health. Current treatment modalities, including radiotherapy, chemotherapy, immunotherapy, and bone marrow transplantation, have demonstrated efficacy but are often limited by side effects, drug resistance, and suboptimal cure rates.
Yaoyao Tian +7 more
wiley +1 more source
Molecules, 2019 This paper presents a comparative study on natural indigo and indirubin in terms of molecular structures and spectral properties by using both computational and experimental methods.
Zixin Ju, Jie Sun, Yanping Liu
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Aryl Hydrocarbon Receptor in Health and Disease
MedComm, Volume 6, Issue 11, November 2025.Based on the structure and ligands of AhR, this review introduces the AhR‐related signaling pathways and their roles in health and diseases. Agonists and antagonists of AhR as well as new strategies for treatment using the microbial–AhR axis are summarized. A prospect was made for the future use of AhR as a therapeutic target.
Haonan Li +11 more
wiley +1 more source
Purple Urine Bag Syndrome [PDF]
Journal of Clinical and Diagnostic Research, 2015 Purple urine bag syndrome (PUBS) is a rare disorder seen in elderly persons, wherein the urinary bag and the tubing turn in to purple colour. It is usually seen in patients who are on urinary catheters for a long time.
NAUFAL RIZWAN TARAGANAR ABUBACKER +4 more
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Convergence of Wnt signalling on the HNF4a-driven transcription in controlling liver zonation [PDF]
, 2009 BACKGROUND & AIMS: In each hepatocyte, the specific repertoire of gene expression is influenced by its exact location along the portocentrovenular axis of the hepatic lobule and provides a reason for the liver functions compartmentalization defined ...
Alonzi, T +7 more
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Clinical Case Reports, Volume 13, Issue 10, October 2025.ABSTRACT The syndrome of inappropriate antidiuretic hormone secretion is a condition marked by the excessive production of antidiuretic hormone, potentially resulting in hyponatremia. If not properly managed, severe hyponatremia can result in seizures, cerebral edema, and even death.
Juan Fu +6 more
wiley +1 more source