Results 81 to 90 of about 297,330 (349)

Formal Synthesis of the Akuammiline Alkaloid (±)‐Strictamine via a (4 + 2) Annulation Reaction With a Donor–Acceptor Cyclobutane

Helvetica Chimica Acta, EarlyView.
We report a concise formal synthesis of (±)‐strictamine via a silylium‐catalyzed (4 + 2) annulation of a donor–acceptor cyclobutane, achieved in 13 steps from tryptamine. ABSTRACT The akuammiline alkaloids are complex monoterpene indole natural products with a rigid cage‐like architecture and diverse biological activities.
Clément Tanguy, Emma G. L. Robert, Jerome Waser   +2 more
wiley   +1 more source

Concise total synthesis of (+)-gliocladins B and C [PDF]

, 2012
The first total synthesis of (+)-gliocladin B is described. Our concise and enantioselective synthesis takes advantage of a new regioselective Friedel–Crafts-based strategy to provide an efficient multigram-scale access to the C3-(3′-indolyl ...
Aliev, Bernardo, Bertinetti, Block, Bruncko, Bull, Carrithers, Chai, Codelli, Coffen, Cook, Crich, Crich, DeLorbe, Depew, Dong, Dong, Espejo, Espejo, Espejo, Fang, Feng, Foo, Frigerio, Fukuyama, Fukuyama, Fukuyama, Furst, Gardiner, Govek, Hamada, Hendrickson, Herscheid, Hino, Hino, Huang, Ishikawa, Iwasa, Iwasa, Jiang, Karaman, Kim, Kim, Kim, Kirby, Kirby, Kishi, Kishi, Kobayashi, Kodanko, Link, Machuqueiro, Marqués-López, Marsden, Matsuda, Matsuda, Miknis, Minato, Minato, Movassaghi, Movassaghi, Movassaghi, Nakagawa, Newhouse, Newhouse, Nicolaou, Nicolaou, Noji, Ottenheijm, Overman, Overman, Overman, Overman, Overman, Patron, Poisel, Poisel, Poisel, Polaske, Pérez-Balado, Pérez-Balado, Pérez-Balado, Rainier, Ruff, Ruiz-Sanchis, Sakai, Sala, Schammel, Scott, Snell, Somei, Steven, Takahashi, Terrasson, Trown, Usami, Villanueva-Margalef, Waring, Waring, Williams, Williams, Wu, Yamada, Yamada, You, Zeng, Zheng, Öhler, Öhler, Řezanka   +109 more
core   +1 more source

Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules

Magnetic Resonance in Chemistry, EarlyView.
Plasma neutrophil elastase(ELANE) was markedly elevated in patients with alcohol use disorder, indicating a dysregulated protease‐antiprotease inflammatory balance characterised by decreased SERPINA3. ELANE showed excellent diagnostic specificity(AUC = 0.8683), supporting its potential utility as a neuroinflammatory biomarker for AUD.
Nilamoni Nath, Juan Carlos Fuentes Monteverde, Swaraj Pathak, Christian Griesinger   +3 more
wiley   +1 more source

Concise total synthesis of (+)-bionectins A and C [PDF]

, 2013
The concise and efficient total synthesis of (+)-bionectins A and C is described. Our approach to these natural products features a new and scalable method for erythro-β-hydroxytryptophan amino acid synthesis, an intramolecular Friedel–Crafts reaction of
Adams, Timothy C., Coste, Alexis, Kim, Justin, Movassaghi, Mohammad   +3 more
core   +1 more source

Terpenoid indole alkaloid biosynthesis in Catharanthus roseus: effects and prospects of environmental factors in metabolic engineering [PDF]

, 2021
Yongliang Liu, Barunava Patra, Sanjay K. Singh, Priyanka Paul, Yan Zhou, Yongqing Li, Ying Wang, Sitakanta Pattanaik, Ling Yuan   +8 more
openalex   +1 more source

Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review

Frontiers in Pharmacology, 2017
Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects.
H. Hamid, A. N. M. Ramli, M. Yusoff
semanticscholar   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, EarlyView.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

Indole Synthesis via Allenyl Ester; Enantioselective Total Synthesis of Geissoschizoline

ChemistryEurope
Methyl indole‐2‐acetate is a key structural motif in plant‐derived indole alkaloids. In this study, a mild and efficient protocol is presented for its preparation using readily available aniline derivatives, which are synthesized from malonic esters. The
Sohsuke Moriue, Honami Nishioka, Yuto Fukuda, Hiromitsu Takayama, Mariko Kitajima, Hayato Ishikawa   +5 more
doaj   +1 more source

The ketogenic diet alters microbiome‐metabolome profiles to improve West syndrome therapy

Pediatric Investigation, EarlyView.
The ketogenic diet alleviates West syndrome by reshaping gut microbiota (increasing Bacteroides, Parabacteroides, and reducing Escherichia and Bifidobacterium), and modulating metabolites—including anticonvulsant lipids (e.g., capric acid), suppressed harmful lipids (e.g., 2‐methylbutyroylcarnitine), and amino acids and analogs (e.g., 3‐sulfinoalanine)—
Gan Xie, Qian Zhou, Jianxiang Liao, Yuejie Zheng, Wenjian Wang, Kunling Shen   +5 more
wiley   +1 more source

High efficiency protoplast isolation from in vitro cultures and hairy roots of Maesa lanceolata [PDF]

, 2010
In vitro cultures of the medicinal plant Maesa lanceolata were established to enable the cultivation of plant material for the production of protoplasts.
Geelen, Danny, Lambert, Ellen
core   +1 more source