Interleukin-6 promotes skeletal muscle catabolism by activating tryptophan-indoleamine 2,3-dioxygenase 1-kynurenine pathway during intra-abdominal sepsis. [PDF]
J Cachexia Sarcopenia Muscle, 2023 Inflammatory cytokine interleukin‐6 (IL‐6) plays a pivotal role in skeletal muscle degradation after intra‐abdominal sepsis (IAS), with mechanism remained to be elucidated. Indoleamine 2,3‐dioxygenase 1 (IDO‐1), a key enzyme in converting tryptophan into
Xie T +10 more
europepmc +2 more sources
Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation [PDF]
Frontiers in Immunology, 2021 The connection between indoleamine 2,3-dioxygenase 1 (IDO1) and tumour dormancy – a quiescent state of tumour cells which has been consistently linked to metastasis and cancer recurrence – is rarely discussed despite the pivotal role of IDO1 in cancer ...
Chao Yang +5 more
doaj +2 more sources
Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1 [PDF]
iScience, 2023 Summary: Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells.
Asha M. Rudjord-Levann +15 more
doaj +2 more sources
Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase. [PDF]
Int J Tryptophan Res, 2022 Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are main enzymes regulating the first and rate ...
Yoshioka S +9 more
europepmc +2 more sources
Indoleamine 2,3 dioxygenase 1 immobilization on magnetic nanoparticles for screening inhibitors from coffee [PDF]
Food Chemistry: X, 2023 In this study, a ligand fishing method was developed to screen potential indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors from coffee extracts by immobilization of IDO1 enzyme on amino-modified magnetic nanoparticles combined with UHPLC-Q-TOF-MS/MS ...
Zhuoting Liu +5 more
doaj +2 more sources
Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 The haem enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyses the rate-limiting step in the kynurenine pathway of tryptophan metabolism and plays an essential role in immunity, neuronal function, and ageing. Expression of IDO1 in cancer cells results in
Ute F. Röhrig +11 more
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Enhancement of radiation therapy by indoleamine 2,3 dioxygenase 1 inhibition through multimodal mechanisms [PDF]
BMC Cancer, 2023 Background Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that converts tryptophan to kynurenine. IDO1 expression is found not only in tumor cells but also in immune cells and is associated with tumor proliferation and immune responses.
Hiroaki Nozawa +9 more
doaj +2 more sources
Indoleamine 2,3-dioxygenase 1 signaling orchestrates immune tolerance in Echinococcus multilocularis-infected mice [PDF]
Frontiers in Immunology, 2022 The cestode Echinococcus multilocularis larva infection causes lethal zoonotic alveolar echinococcosis (AE), a disease posing a great threat to the public health worldwide.
Ru Meng +7 more
doaj +2 more sources
The tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase 1 regulates polycystic kidney disease progression [PDF]
JCI Insight, 2023 Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic nephropathy, is characterized by phenotypic variability that exceeds genic effects. Dysregulated metabolism and immune cell function are key disease modifiers. The tryptophan
Dustin T. Nguyen +9 more
doaj +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Indoleamine 2,3-dioxygenase 1 (IDO1), a tryptophan catabolising enzyme, is known as a tumour cell survival factor that causes immune escape in several types of cancer.
Mincheol Kwon +11 more
doaj +2 more sources