Results 61 to 70 of about 44,829 (223)

Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool

Frontiers in Immunology, 2020
Indoleamine 2,3-dioxygenase 2 (IDO2) is an analog of the tryptophan degrading and immunomodulating enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Although the role of IDO1 is largely understood, the function of IDO2 is not yet well-elucidated.
Martina Mandarano, Guido Bellezza, Maria Laura Belladonna, Jacopo Vannucci, Alessio Gili, Ivana Ferri, Chiara Lupi, Vienna Ludovini, Giulia Falabella, Giulio Metro, Giada Mondanelli, Rita Chiari, Lucio Cagini, Fabrizio Stracci, Fabrizio Stracci, Fausto Roila, Francesco Puma, Claudia Volpi, Angelo Sidoni   +18 more
doaj   +1 more source

The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells. [PDF]

, 2014
Dendritic cells (DCs) are professional APCs that have a role in the initiation of adaptive immune responses and tolerance. Among the tolerogenic mechanisms, the expression of the enzyme IDO1 represents an effective tool to generate T regulatory cells. In
Ciciarello, M., Curti, A., Evangelisti, C., Jandus, C., Laury-Kleintop, L., Lecciso, M., Lemoli, R.M., Metz, R., Očadlíková, D., Prendergast, G.C., Romero, P., Salvestrini, V., Trabanelli, S.   +12 more
core   +2 more sources

Involvement of the kynurenine pathway in human glioma pathophysiology.

PLoS ONE, 2014
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), the excitotoxin, quinolinic acid (QUIN) and the ...
Seray Adams, Charles Teo, Kerrie L McDonald, Anna Zinger, Sonia Bustamante, Chai K Lim, Gayathri Sundaram, Nady Braidy, Bruce J Brew, Gilles J Guillemin   +9 more
doaj   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Kynurenines as a Novel Target for the Treatment of Inflammatory Disorders

Cells
This review discusses the potential of targeting the kynurenine pathway (KP) in the treatment of inflammatory diseases. The KP, responsible for the catabolism of the amino acid tryptophan (TRP), produces metabolites that regulate various physiological ...
Adrian Mor, Anna Tankiewicz-Kwedlo, Marianna Ciwun, Janina Lewkowicz, Dariusz Pawlak   +4 more
doaj   +1 more source

Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon γ gene transfer on interferon γ-mediated antitumor activity. [PDF]

, 2014
Interferon γ (IFN-γ), an anticancer agent, is a strong inducer of indoleamine 2, 3-dioxygenase 1 (IDO1), which is a tryptophan-metabolizing enzyme involved in the induction of tumor immune tolerance.
Ando, M, Nishikawa, M, Saito, K, Takahashi, Y, Takakura, Y, Watanabe, Y, Watcharanurak, K, Yamamoto, Y, Yoshinaga, K, Zang, L   +9 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

The kynurenine pathway and the brain: challenges, controversies and promises [PDF]

, 2017
Research on the neurobiology of the kynurenine pathway has suffered years of relative obscurity because tryptophan degradation, and its involvement in both physiology and major brain diseases, was viewed almost exclusively through the lens of the well ...
Schwarcz, Robert, Stone, Trevor W.
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Peritumoral endothelial indoleamine 2,3-dioxygenase expression is an early independent marker of disease relapse in colorectal cancer and is influenced by DNA mismatch repair profile [PDF]

, 2018
Targeting immune checkpoint molecules has become a major new strategy in the treatment of several cancers. Indoleamine 2,3-dioxygenase (IDO)-inhibitors are a potential next-generation immunotherapy, currently investigated in multiple phase I-III trials ...
Brochez, Lieve, CHEVOLET, INES, De Man, Marc, Demetter, Pieter, Ferdinande, Liesbeth, Geboes, Karen, Hulstaert, Eva, Kruse, Vibeke, Meireson, Annabel, Ost, Piet, Van de Putte, Dirk, Verset, Laurine   +11 more
core   +2 more sources