Results 181 to 190 of about 309,089 (339)
Advanced Science, EarlyView.Patch‐clamp experiments are fundamental to the measurement and understanding of ion currents that underlie physiological functions from neural activity to muscle contraction. Via a mathematical model of the experimental apparatus, this article highlights how artifact effects can be as large as some reported mutation and drug effects, and enables ...
Chon Lok Lei +8 more
wiley +1 more source
Generation of Induced Pluripotent Stem Cells from Human Cord Blood Using OCT4 and SOX2
, 2009 Alessandra Giorgetti +12 more
openalex +1 more source
Generation of Induced Pluripotent Stem Cells by Reprogramming Mouse Embryonic Fibroblasts with a Four Transcription Factor, Doxycycline Inducible Lentiviral Transduction System [PDF]
, 2009 Brad Hamilton +3 more
openalex +1 more source
Advanced Science, EarlyView.A gastrula‐premarked enhancer within the first intron of Cdx2 governs posterior embryonic development via both regulating Cdx2 expression in cis and coordinating TGF‐β signaling in trans to ensure proper posterior body development. Functional rescue in gastruloids reveals a Cdx2‐independent pathway, highlighting p‐Enh‐eRNA as key epigenetic ...
Yingying Chen +16 more
wiley +1 more source
Reprogrammed induced pluripotent stem cells: how suitable could they be in reproductive medicine? [PDF]
, 2009 Roberto Enseñat‐Waser +2 more
openalex +1 more source
Human Nervous System‐Based Biohybrid Robot‐On‐A‐Chip with Sensing Function for Toxicity Screening
Advanced Science, EarlyView.Human nervous system‐based biohybrid robot‐on‐a chip with eye function as sensing system in addition to brain/motor neuron/muscle functions is proposed. Upon light stimulation, the eye assembloid generates electrophysiological signals, which are transmitted through the cerebral organoid and motor neuron spheroid, inducing muscle movement.
Minkyu Shin +6 more
wiley +1 more source
Translational Research in Anatomy, 2015 Over the past few years, the understanding of stem cells as a potential therapeutic source has significantly evolved, and the previous concept of irreparable neural injury is being reconsidered.
Nimer Adeeb +9 more
doaj
Generation of functional human hepatic endoderm from human induced pluripotent stem cells [PDF]
, 2009 Gareth J. Sullivan +16 more
openalex +1 more source
A Complementarity‐Based Approach to De Novo Binder Design
Advanced Science, EarlyView.A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko +17 more
wiley +1 more source
Directed Differentiation of Human-Induced Pluripotent Stem Cells Generates Active Motor Neurons [PDF]
, 2009 Saravanan Karumbayaram +12 more
openalex +1 more source