Results 191 to 200 of about 309,089 (339)

Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

Advanced Science, EarlyView.
This study proposes that adhesion–clutch can mediate both cell motility and immobilization depending on the force amplitude. Weak adhesion–clutch is well‐suited for cell migration, without forming strong adhesions that impede cell motility. It propels rapid dendritic cell migration controlled by extracellular chemicals, as well as pathologically ...
Kentarou Baba, Ami Fukushi‐Kumagai, Megumi Morisaki, Ryosuke Takeuchi, Zhize Xiao, Yoshikazu Nagashima, Mizuki Sakai, Yasuna Higashiguchi, Hiroko Katsuno‐Kambe, Asako Katsuma, Yoshihiro Ueda, Yuji Kamioka, Daisuke Kawauchi, Tatsuo Kinashi, Yonehiro Kanemura, Naoyuki Inagaki   +15 more
wiley   +1 more source

A Robust Approach to Identifying Tissue-Specific Gene Expression Regulatory Variants Using Personalized Human Induced Pluripotent Stem Cells

, 2009
Je‐Hyuk Lee, In‐Hyun Park, Yuan Gao, Jin Billy Li, Zhe Li, George Q. Daley, Kun Zhang, George M. Church   +7 more
openalex   +2 more sources

Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells under Xeno-free Conditions [PDF]

, 2009
Ignasi Rodríguez-Pizà, Yvonne Richaud‐Patín, Rita Vassena, Federico González, María J. Barrero, Anna Veiga, Ángel Raya, Juan Carlos Izpisúa Belmonte   +7 more
openalex   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Induced Pluripotent Stem Cells for the Treatment of Lysosomal Storage Disorders. [PDF]

J Inherit Metab Dis
Lorino M, Qiu B, Bigger B.
europepmc   +1 more source

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

Advanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai, Yuxin Zhao, Zilong Li, Liping Xiao, Yifan Wu, Shiya Wang, Qian Liu, Yida Ye, Yuxuan Guo, Donghui Zhang   +9 more
wiley   +1 more source

Application of induced pluripotent stem cells in the conservation of endangered animals. [PDF]

Stem Cell Res Ther
Lou J, Li W, Chen P, Chen H, Shakoor A, Chen Y, Hua J, Wang Y, Zhang S.   +8 more
europepmc   +1 more source

Orderly hematopoietic development of induced pluripotent stem cells via Flk‐1⁺ hemoangiogenic progenitors [PDF]

, 2009
Akira Niwa, Katsutsugu Umeda, Hsi Chang, Megumu K. Saito, Keisuke Okita, Kazutoshi Takahashi, Masato Nakagawa, Shinya Yamanaka, Tatsutoshi Nakahata, Toshio Heike   +9 more
openalex   +1 more source

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

Differentiation of Human Induced Pluripotent Stem Cells Toward Implantable Chondroprogenitor Cells. [PDF]

Cartilage
Ekholm J, Vukusic K, Brantsing C, Shaw G, Ur Rehman Bhatti F, Simonsson S, Falk A, Murphy M, Rotter Sopasakis V, Lindahl A.   +9 more
europepmc   +1 more source