Results 191 to 200 of about 227,684 (338)

Generation of homozygous PRKN, PINK1 and double PINK1/PRKN knockout cell lines from healthy induced pluripotent stem cells using CRISPR/Cas9 editing

, 2022
Carol X.‐Q. Chen, Zhipeng You, Narges Abdian, Julien Sirois, Irina Shlaifer, Mahdieh Tabatabaei, Marie‐Noëlle Boivin, Lydiane Gaborieau, Jason Karamchandani, Lenore K. Beitel, Edward A. Fon, Thomas M. Durcan   +11 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Editorial: Role of induced pluripotent stem cells (iPSCs) in regenerative medicine, disease modeling and drug discovery. [PDF]

Front Bioeng Biotechnol
O'Connor KC, Stanley HJ, Bunnell BA, De Caro R.   +3 more
europepmc   +1 more source

PEDOT:PSS—A Key Material for Bioelectronics

Advanced Science, EarlyView.
PEDOT:PSS ‐ Poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate ‐ is typically processed from water dispersions to form multifunctional and multidimensional constructs with tunable electronic and ionic conductivity. Throught processing engineering, PEDOT:PSS is intergrated in bioelectronic devices that operate efficiently in physiological conditions
Alan Eduardo Ávila Ramírez, David Pieter van der Laan, Mustafeez Bashir Shah, Liwen Wang, Erica Zeglio, Achilleas Savva   +5 more
wiley   +1 more source

Karyotypic Profiling of Induced Pluripotent Stem Cells Derived from a Xeroderma Pigmentosum Group C Patient. [PDF]

Cells
Alsalloum A, Mingaleva N, Gornostal E, Antysheva Z, Sparber P, Skoblov M, Pozhitnova V, Belysheva T, Levashova A, Kuznetsova E, Suvorova Y, Krupinova J, Bogdanov V, Abyzov A, Mityaeva O, Volchkov P.   +15 more
europepmc   +1 more source

Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1 -associated Retinitis pigmentosa

, 2017
Tasneem P. Sharma, Luke A. Wiley, S. Scott Whitmore, Kristin R. Anfinson, Cathryn M. Cranston, Douglas J. Oppedal, Heather T. Daggett, Robert F. Mullins, Budd A. Tucker, Edwin M. Stone   +9 more
openalex   +1 more source

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells [PDF]

, 2011
Ori Bar‐Nur, Holger A. Russ, Shimon Efrat, Nissim Benvenisty   +3 more
openalex   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

A Nanoformulation of Ubiquinol and Selenium Promotes Proliferation of Human Induced Pluripotent Stem Cells. [PDF]

Antioxidants (Basel)
Nguemo F, Zhang H, Koester A, Rohani S, Perumal Srinivasan S, Hescheler J.   +5 more
europepmc   +1 more source

Current Status of Cardiac Regenerative Therapy Using Induced Pluripotent Stem Cells [PDF]

Tadahisa Sugiura, Dhienda C. Shahannaz, Brandon E. Ferrell   +2 more
openalex   +1 more source