Results 101 to 110 of about 17,832 (233)

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Photothermal Microneedle Hydrogel Patch for Refractory Soft Tissue Injuries through Thermosensitized Anti‐Inflammaging Modulation

Small Structures
Soft tissue injuries (STIs) are the most common cause of extremity pain and motion dysfunction. Persistent inflammatory activation of immune cells characterized by senescence‐associated secretory phenotype (SASP) and mitochondrial stress are considered ...
Wanbo Zhu, Quan Liu, Ziheng Zhang, Yingjie Wang, Jiawei Mei, Dongdong Xu, Jun Zhou, Zheng Su, Xianzuo Zhang, Chen Zhu, Jiaxing Wang, Junchen Zhu, Xiaochun Peng, Xianlong Zhang   +13 more
doaj   +1 more source

Ganoderma Microsporum Immunomodulatory Protein Alleviates Inflammaging and Oxidative Stress in Diabetes-Associated Periodontitis via Nrf2 Signaling Activation: An In Vitro Study

Antioxidants
Periodontitis, characterized by inflammation and loss of periodontal tissue, is a significant health complication for individuals with diabetes mellitus (DM).
Ni-Yu Su, Min Yee Ng, Heng-Yi Liao, Yi-Wen Liao, Movina Wu, Shih-Chi Chao, Cheng-Chia Yu, Yu-Chao Chang   +7 more
doaj   +1 more source

Inflammation Affects the Osteogenic Differentiation of Aged Periodontal Ligament Cells via NF‐κB/FOXO3a/c‐JUN Signalling

Journal of Periodontal Research, EarlyView.
NF‐κB/FOXO3a/c‐JUN pathway plays a crucial role in osteogenic. Differentiation of aged PDLCs in an inflammatory microenvironment, although the mechanisms of this pathway differ in cellular ageing and pathological inflammation. ABSTRACT Aim This study aims to investigate the effect of inflammation on the senescence phenotype and osteogenic capacity of ...
Luying Zhu, Zhongyuan Tang, Renjie Hu, Yaxin Li, Xuan Li, Min Gu, Yanqi Yang   +6 more
wiley   +1 more source

Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids

Cells, 2020
Age-associated changes leading to a decline in cardiac structure and function contribute to the increased susceptibility and incidence of cardiovascular diseases (CVD) in elderly individuals.
Hedieh Keshavarz-Bahaghighat, Ahmed M. Darwesh, Deanna K. Sosnowski, John M. Seubert   +3 more
doaj   +1 more source

Breast Tissue Biology Expands the Possibilities for Prevention of Age-Related Breast Cancers. [PDF]

, 2019
Preventing breast cancer before it is able to form is an ideal way to stop breast cancer. However, there are limited existing options for prevention of breast cancer.
Fresques, Tara, LaBarge, Mark A, Preto, Sandy, Samson, Susan, Shalabi, Sundus, Stampfer, Martha R, Zirbes, Arrianna   +6 more
core  

The Role of Wnt Signaling in Age‐Related Alveolar Bone Loss and Regeneration

Journal of Periodontal Research, EarlyView.
The graphical abstract summarizes key signaling pathways involved in bone formation and resorption associated with Wnt signaling across young and aged long bone and jaw tissues. Levels of evidence are indicated as robust, moderate, or emerging, reflecting the current experimental support in each context.
Hsiao H. Sung, Navya Chalamalasetty, Ali Alzainal, Hanlong Liu, Lexuan Wang, Pietra Colacrai Arikita, Ivy C. X. Wei, Hom‐Lay Wang, M. H. J. van den Bosch, Michelle S. Caird, Peter M. van der Kraan, Kenneth M. Kozloff, Esmeralda Blaney Davidson   +12 more
wiley   +1 more source

Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging

Experimental Gerontology
Ageing is accompanied by a decline in immune function (immunosenescence), increased inflammation (inflammaging), and more senescent cells which together contribute to age-related disease and infection susceptibility. The innate immune system is the front-
Shaun Hanley, Yung-Yi Chen, Jon Hazeldine, Janet M. Lord   +3 more
doaj   +1 more source

Lifelong calorie restriction affects indicators of colonic health in aging C57Bl/6J mice [PDF]

, 2018
Diminished colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an effective strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here, we report the effects of lifelong
Franceschi, Claudio, Kampman, Ellen, Kok, Dieuwertje EG, Laghi, Luca, Lute, Carolien, Müller, Michael, Picone, Gianfranco, Rusli, Fenni, Salvioli, Stefano, Smidt, Hauke, Steegenga, Wilma T, van der Lugt, Benthe, Vervoort, Jacques   +12 more
core   +2 more sources

IMMUNOMETABOLIC CHECKPOINTS OF INFLAMMAGING

Innovation in Aging, 2023
Abstract Inflammation is a key hallmark and driver of age-related functional decline. Evidence that innate immune sensor NLRP3 inflammasome links aging to functional decline supports Metchnikoff’s original prediction that phagocytes or macrophages drive aging-associated degenerative diseases in an organism.
openaire   +1 more source