Results 111 to 120 of about 17,832 (233)

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

Frontiers in Immunology, 2017
Advanced age is associated with chronic low-grade inflammation, which is usually referred to as inflammaging. Elderly are also known to have an altered gut microbiota composition.
Floris Fransen, Floris Fransen, Adriaan A. van Beek, Adriaan A. van Beek, Theo Borghuis, Theo Borghuis, Sahar El Aidy, Floor Hugenholtz, Floor Hugenholtz, Christa van der Gaast – de Jongh, Huub F. J. Savelkoul, Marien I. De Jonge, Mark V. Boekschoten, Mark V. Boekschoten, Hauke Smidt, Hauke Smidt, Marijke M. Faas, Marijke M. Faas, Paul de Vos, Paul de Vos   +19 more
doaj   +1 more source

EPA+DHA Oral Therapy Reduces High Levels of Circulating Pro-Inflammatory Cytokines in Older Adults with Chronic Wounds [PDF]

, 2018
High levels of circulating pro-inflammatory cytokines contribute to inflammaging, the age-related chronic systemic inflammation involved in the pathobiology of numerous chronic conditions common to older adults (e.g., cardiovascular disease (CVD ...
Wood, Sarah
core  

Inflammation, genetic background and longevity [PDF]

, 2010
Ageing is an inexorable intrinsic process that affects all cells, tissues, organs and individuals. Due to a diminished homeostasis and increased organism frailty, ageing causes a reduction of the response to environmental stimuli and, in general, is
A Panda, B Grubeck-Loebenstein, BR Troen, C Caruso, C Franceschi, C Franceschi, C Franceschi, C Franceschi, C Miyaji, C Wei, Calogero Caruso, CE Finch, CR Balistreri, D Di Bona, D Duin van, DP Harris, E Cevenini, F Licastro, F Listì, F Listì, F Martin, G Candore, G Candore, G Candore, G Candore, G Candore, G Colonna-Romano, G Colonna-Romano, G Colonna-Romano, G Di Lorenzo, G Pawelec, G Pawelec, G Pawelec, Giuseppina Candore, Giuseppina Colonna-Romano, HY Chung, I Sanz, J Oeppen, K Ogata, KF Kong, KL Gibson, KP High, M Capri, M Goto, M Jylhä, M la Fuente De, M Martinis De, MP Viveros, OT Chan, P Alonso-Fernández, P Sansoni, P Szabo, P Trzonkowski, R Ostan, R Vescovini, S Gupta, S Salvioli, S Vasto, S Vasto, S Vasto, S Vasto, SI Rattan, SJ Olshansky, Y Niwa, Y Shi, Y Shi   +65 more
core   +1 more source

Inflammaging and Brain Aging

International Journal of Molecular Sciences
Progress made by the medical community in increasing lifespans comes with the costs of increasing the incidence and prevalence of age-related diseases, neurodegenerative ones included. Aging is associated with a series of morphological changes at the tissue and cellular levels in the brain, as well as impairments in signaling pathways and gene ...
Maria Carolina Jurcau, Anamaria Jurcau, Alexander Cristian, Vlad Octavian Hogea, Razvan Gabriel Diaconu, Vharoon Sharma Nunkoo   +5 more
openaire   +2 more sources

Oral wound healing in the elderly: Mechanisms, challenges, and innovations

Periodontology 2000, EarlyView.
Abstract Objective This narrative synthesizes current knowledge on the biological mechanisms, clinical challenges, and regenerative innovations for optimizing intraoral wound healing in the elderly. Methods Narrative review of preclinical and clinical studies addressing age‐related changes in the four canonical wound‐healing phases (hemostasis ...
Ann M. Decker, Sandra H. Stuhr, Gustavo Avila‐Ortiz, Andrea Pilloni, Lorenzo Marini, Rogerio Castilho, Beth I. Wallace, Yvonne L. Hernandez‐Kapila   +7 more
wiley   +1 more source

Corylin ameliorates inflammaging and pyroptosis in diabetic periodontitis: A preliminary in vitro study

Journal of Dental Sciences
Background/purpose: Diabetic periodontitis (DP) is a severe oral disease characterized by hyperinflammation and impaired wound healing, with inflammaging and pyroptosis playing key roles in its pathogenesis.
Taichen Lin, Min Yee Ng, Chun-Te Ho, Yi-Wen Liao, Cheng-Chia Yu, Chun-Jung Chen   +5 more
doaj   +1 more source

Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus [PDF]

, 2019
During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral ...
Amatore, D, Brundu, S, Celestino, I, Checconi, P, Coluccio, P, Fraternale, A, Galluzzi, L, Magnani, M, Nencioni, L, Palamara, A. T.   +9 more
core   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source

Changes in plasma metabolite concentrations and enzyme activities in aging riding horses

Frontiers in Veterinary Science
In older horses, basal metabolic rate decreases, and plasma metabolite and hormone concentrations related to energy metabolism change. The occurrence of age-related diseases, which increases in old animals, may enhance inflammatory reactivity ...
Yukari Asahi, Toshiro Arai, Yoshikazu Tanaka   +2 more
doaj   +1 more source

Frailty status in older adults is related to alterations in indoleamine 2,3-dioxygenase 1 and guanosine triphosphate cyclohydrolase I enzymatic pathways [PDF]

, 2017
Original studyXunta de Galicia; ED431B 2016/013Xunta de Galicia; GPC2014/082Xunta de Galicia; IN607C 2016 ...
Fuchs, Dietmar, Gostner, Johanna, Laffon, Blanca, Lorenzo-López, Laura, Marcos Pérez, Diego, Maseda, Ana, Millán-Calenti, José Carlos, Pásaro, Eduardo, Strasser, Barbara, Sánchez-Flores, María, Valdiglesias, Vanessa   +10 more
core   +2 more sources