Results 121 to 130 of about 17,832 (233)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Characterisation of bacteria‐induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease

The Journal of Pathology, Volume 268, Issue 4, Page 493-511, April 2026.
Abstract Enteropathogenic bacteria are a major cause of morbidity and mortality globally. While mouse models have been indispensable in advancing our understanding of infectious enteric diseases, key differences in intestinal microbiota and immunobiology between mice and humans underscore the need for alternative mammalian models that better ...
Daniel W. Hart, Aik Seng Ng, Patrycja Gazińska, Robert Goldin, Purva Gopal, Nicolize O'Dell, Ahmad Zargar, Lior Pytowski, Shamir Montazid, Chiara Bardella, James E. East, Ian P. Tomlinson, Nadine Koch, Nigel C. Bennett, Shazia Irshad   +14 more
wiley   +1 more source

Single-cell transcriptomics identifies the common perturbations of monocyte/macrophage lineage cells in inflammaging of bone marrow

Journal of Orthopaedic Translation
Background: Bone marrow inflammaging is a low-grade chronic inflammation that induces bone marrow aging. Multiple age-related and inflammatory diseases involve bone marrow inflammaging.
Peng Liao, Sihan Tong, Lin Du, Jiong Mei, Bingqi Wang, Yafei Lu, Meng Yao, Changqing Zhang, Delin Liu, Zhigang Zhong, Fang Ye, Junjie Gao   +11 more
doaj   +1 more source

Biomarkers of aging associated with past treatments in breast cancer survivors. [PDF]

, 2017
Radiation and chemotherapy are effective treatments for cancer, but are also toxic to healthy cells. Little is known about whether prior exposure to these treatments is related to markers of cellular aging years later in breast cancer survivors.
Bower, Julienne E, Breen, Elizabeth C, Carroll, Judith E, Chapman, Aaron M, Esquivel, Stephanie, Ganz, Patricia A, Hogan, Matt, Irwin, Michael R, Petersen, Laura, Ramos-Perlberg, Sam, Schiestl, Robert, Scuric, Zorica   +11 more
core   +2 more sources

Role of Succinate Dehydrogenase in Age‐Related Th17 Inflammation

Aging Cell, Volume 25, Issue 4, April 2026.
Age‐induced mitoSTAT3‐dependent upregulation of mitochondrial complex II; succinate dehydrogenase (SDH), in CD4+ T cells promotes an imbalance in the levels of metabolites succinate and fumarate, characterized by lower succinate and higher fumarate. Changes in the metabolites alter mitochondrial structure and function and promote HIF1α to induce the ...
Evelyn Ocegueda, Gabrielle Chase, Michaella Niceforo, Aida Javidan, Lydia Gugliuzza, Jingting Yu, Rachel Y. Kang, Ava Lankowski, Olivia Stefanik, Kailey Leclerc, Yolander Valentine, Micah J. Drummond, Jude T. Deeney, Josephine S. Modica‐Napolitano, Elizabeth A. Proctor, Hatice Hasturk, Barbara S. Nikolajczyk, Leena P. Bharath   +17 more
wiley   +1 more source

Senescence‐Driven IL‐17A Inflammatory Circuit Promotes Epithelial–Mesenchymal Transition (EMT) and Progression in Age‐Related Posterior Subcapsular Cataracts

Aging Cell, Volume 25, Issue 4, April 2026.
Using multi‐region human PSC samples, we identified EMT as a consistent pathological feature. Mechanistically, senescent LECs secrete IL‐17A, a representative SASP factor, which activates NF‐κB signaling. NF‐κB further amplifies SASP production, thereby establishing a senescence–inflammation feedback loop that drives EMT, sustains pathological ...
Yan Ni, Yu Ma, Zewen Ren, Yi Zhu, Liangping Liu, Runping Duan, Lu Qin, Yang Chen, Rong Ju, Yingyan Qin, Mingxing Wu   +10 more
wiley   +1 more source

Does Time Tick Faster in Cerebral Palsy? Accelerated Aging as a Framework for Skeletal Muscle Dysfunction

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Skeletal muscle in individuals with cerebral palsy (CP) may undergo accelerated aging through mechanisms shared with age‐related sarcopenia. Representative overlapping molecular and cellular features include, for example, neuromuscular alterations, impaired satellite cell function and niche composition, chronic inflammation, metabolic deficits, reduced
Oscar Horwath, Sebastian Edman, Sudarshan Dayanidhi, Davis Englund, Mark D. Peterson, Ferdinand von Walden   +5 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, Volume 7, Issue 1, Page 21-31, March 2026.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, Volume 13, Issue 16, 18 March 2026.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, Volume 13, Issue 14, 9 March 2026.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source