Results 131 to 140 of about 17,832 (233)
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Aging-Driven Inter-Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty. [PDF]
FASEB JPostmenopausal osteoporosis (PMOP) is increasingly recognized as an aging‐associated, multisystem state of fragility, in which estrogen deficiency exacerbates immune and metabolic drift across the bone marrow, skeletal muscle, adipose tissue, gut, vascular system, and neural circuits.
Rao X, Cai X.
europepmc +2 more sources
Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis
Frontiers in AgingBackgroundInflammaging, defined as chronic low-grade inflammation associated with aging, is considered a key factor in many age-related diseases. Despite growing research, comprehensive assessments of trends and focuses on this field over the past 2 ...
Beier Jiang +15 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 3, March 2026.Exercise and dietary polyphenols enhance hippocampal plasticity and cognitive function via complementary molecular mechanisms. Central pathways include BDNF signaling, inflammation control, and mitochondrial regulation. Although synergy is mainly supported by preclinical data, lifestyle‐based strategies show promise for brain health maintenance ...
Zhenyi Zhao, Sima‐sadat Sabihi
wiley +1 more source
BiomedicinesThe term ‘inflammaging’ has been coined to describe the chronic state of inflammation derived from ongoing cycles of tissue damage and the subsequent immune responses.
Mario Caldarelli +6 more
doaj +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Immunity & AgeingAging is associated with systemic chronic, low-grade inflammation, termed ‘inflammaging’. This pattern of inflammation is multifactorial and is driven by numerous inflammatory pathways, including the inflammasome.
Sarah Talley +8 more
doaj +1 more source
MoleculesInflammaging is a chronic, low-grade inflammatory state that contributes to age-related diseases, including cardiovascular disorders, osteoporosis, neurodegeneration, and cancer. This process involves immunosenescence, oxidative stress, and immune aging,
Raffaele Cordiano +4 more
doaj +1 more source
Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao +5 more
wiley +1 more source