Results 141 to 150 of about 17,832 (233)
Aging Cell, Volume 25, Issue 3, March 2026.The left panel shows cerebral lactate homeostasis in young mice. The middle panel displays accelerated ANLS rates due to FGF21 secretion in aging mice. The right panel demonstrates that lactate uptake and usage inhibition contribute to lactate extracellular accumulation, followed by HCA1‐mediated learning and memory decline in mice.
Keru Ji +6 more
wiley +1 more source
Aging Cell, Volume 25, Issue 3, March 2026.In 83 older adults, baseline lymphocyte phenotypes quantified by flow cytometry predicted the magnitude and direction of HRV shifts during a 2‐min step test and recovery. Bayesian models show that the immune landscape shapes exercise autonomic trajectories in a domain‐specific manner, revealing heterogeneity in physiological resilience.
Matías Castillo‐Aguilar +5 more
wiley +1 more source
Anemia in the frail, elderly patient
Clinical Interventions in Aging, 2016 Gabriele Röhrig1,2 1Ageing Clinical Research, Department II of Internal Medicine, University Hospital Cologne, 2Department of Geriatrics, St Marien Hospital Cologne, Cologne, Germany Abstract: Anemia and frailty are two common findings in ...
Röhrig G
doaj
Neoplasia: An International Journal for Oncology ResearchGlioblastoma, isocitrate dehydrogenase (IDH)-wildtype (GBM), is the most malignant brain tumor in adults, with limited therapeutic intervention. Previous studies have identified a few prognostic markers for GBM, including the methylation status of O6 ...
Soon Sang Park +10 more
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Aging Cell, Volume 25, Issue 3, March 2026.This study aims to develop an immune cell atlas of the “Longevity Molecular Tags” by employing the Scissor algorithm to identify key immune cell subsets associated with longevity phenotypes. Subsequently, the underlying immune molecular mechanisms contributing to the longevity‐associated immune cell subsets were investigated through differential gene ...
Zhiling Zhang +10 more
wiley +1 more source
Archives of Gerontology and Geriatrics PlusThe aging population presents complex challenges to oral health, particularly due to inflammaging, a chronic, low-grade systemic inflammation linked to tissue degeneration and frailty syndrome. Despite its relevance, inflammaging remains underexplored in
Olga Naka +3 more
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A Multi‐Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice
Aging Cell, Volume 25, Issue 3, March 2026.A gut‐derived metabolic signature drives systemic aging phenotypes. Integrated multi‐omics profiling of young versus aged mice identifies a conserved aging signature characterized by the depletion of protective lysophosphatidylcholines (LPC 22:0) and the concurrent accumulation of pro‐oxidative microbial catabolites (TMAO, IAA).
Sanaullah Sajid +6 more
wiley +1 more source
Aging Cell, Volume 25, Issue 3, March 2026.Aging is associated with a senescent‐like phenotype in neutrophils that emerges in bone marrow cells; however, many facets of this phenotype are only fully acquired upon entry into peripheral tissues. This neutrophil senescent‐like phenotype is in part driven by TNFα and impairs resistance of aged hosts to S. pneumoniae. Created in BioRender. Boughanem
Michael C. Battaglia +13 more
wiley +1 more source
Aging Cell, Volume 25, Issue 3, March 2026.Using sets of biomarkers of human ageing, a ‘bioage’ score was established allowing calculation of ‘age difference’ (bioage minus chronological age). Age difference, but not chronological age, was correlated with levels of HDL, Vitamin D, and CD3+ CD4+/CD45+ ratio, with biologically younger subjects displaying favourable values, pointing to a role of ...
María Moreno‐Villanueva +52 more
wiley +1 more source