Results 151 to 160 of about 17,832 (233)

Altered Cytokine‐Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine‐Non‐Responsiveness in Aging and HIV

Aging Cell, Volume 25, Issue 3, March 2026.
Chronic immune activation and inflammation associated with aging and HIV skew Tfh signaling toward enhanced IL‐2–STAT5 activation, reinforcing IL‐2R expression through a positive feedback loop and suppressing Tfh helper differentiation programs, thereby contributing to impaired vaccine responsiveness.
Sheldon Davis, Jonah Kupritz, Prabhsimran Singh, Savita Pahwa, Suresh Pallikkuth   +4 more
wiley   +1 more source

Alpha synuclein and inflammaging

Heliyon
The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with inflammasomes in response to aging.
Geneviève L. Putnam, Robert W. Maitta
openaire   +2 more sources

Physical Fitness Dynamics Shape Immune Remodeling in Healthy Aging: A 3‐Year Longitudinal Study

Aging Cell, Volume 25, Issue 3, March 2026.
In a 3‐year longitudinal study of healthy older adults, intraindividual declines in physical fitness and strength were linked to dynamic immune remodeling, including shifts toward senescent and regulatory T cell phenotypes, despite stable activity levels.
Christopher Weyh, Vincent Größer, Luciele Guerra Minuzzi, Torsten Frech, Kristina Gebhardt, Svenja Nolte, Theresa Dombrowski, Manuela Andrea Hoffmann, Natascha Sommer, Robert Ringseis, Klaus Eder, Samuel Sossalla, Pascal Bauer, Karsten Krüger   +13 more
wiley   +1 more source

Changes of erythropoiesis in case of chronic obstructive pulmonary disease and urolithiasis comorbidity [PDF]

, 2016
In comorbidity of chronic obstructive pulmonary disease and urolithiasis with oxalic acid stones changes of erythropoiesis were found in 78,3 % of patients, in particular – 52,2 % corresponded to mild iron-deficiency anemia and in 26,1 % of patients ...
Khukhlina, O.S., Viligorska, K.V.
core  

Cardiometabolic‐Inflammatory Risk Factors and Cognitive Decline Among Older Indians—Report From a Nationally Representative, Longitudinal Study

Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 800-806, March 2026.
ABSTRACT Background Rapid increase in cardiometabolic diseases in India may contribute to increased incidence of late‐life cognitive impairment. This study focuses on associations between baseline cardiometabolic risk factors and subsequent decline in cognitive function among older adults in India, leveraging data from two waves (Wave 1: 2017–2020 ...
Joyita Banerjee, Jung Ki Kim, Emma Nichols, Pranali Khobragade, A. B. Dey, Sharmistha Dey, Eileen Crimmins, David Flood, Kenneth M. Langa, Jinkook Lee, Peifeng Hu   +10 more
wiley   +1 more source

MAM‐STAT3‐Driven Mitochondrial Ca+2 Upregulation Contributes to Immunosenescence in Type A Mandibuloacral Dysplasia Patients

Advanced Science
Individuals with homozygous laminA/C p.R527C mutations manifest a severe form of Mandibuloacral dysplasia‐(MAD) and exhibit overlapping progeroid symptoms, for which the underlying molecular pathology remains unknown.
Arshad Ahmed Padhiar, Xiaohong Yang, Syed Aqib Ali Zaidi, Zhu Li, Jinqi Liao, Wei Shu, Arif Ali Chishti, Liangge He, Gulzar Alam, Abdullah Faqeer, Ilyas Ali, Shuai Zhang, Ting Wang, Tao Liu, Meiling Zhou, Gang Wang, Yan Zhou, Guangqian Zhou   +17 more
doaj   +1 more source

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 636-647, March 2026.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

Mitochondria and oxidative stress participation in renal inflammatory process [PDF]

, 2014
La muerte celular programada y fibrosis renal son procesos inherentes a la enfermedad renal crónica, y en tal sentido ha sido recientemente descripto, una clara desregulación de la maquinaria respiratoria mitocondrial en pacientes con enfermedad renal ...
Manucha, Walter Ariel Fernando
core  

Circulating Myokine Responses to Acute Endurance Exercise and Their Role in Immunoregulation: A Systematic Review and Meta‐Analysis

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
This systematic review and meta‐analysis, which examined the effects of acute endurance training on immunoregulatory myokines, showed significant small‐moderate to very large positive effect sizes for IL‐6, IL‐10, IL‐1ra, IL‐8, IL‐15, and TNF‐α. These effects were significantly moderated by risk of bias, sex, age, V̇O2peak, experience, type of exercise,
Miriam Ringleb, Fabian Fabritius, Jakob Godde, Christian Puta, Wilhelm Bloch, Florian Javelle   +5 more
wiley   +1 more source

Diet and Exercise Interventions in Pediatric Cancer Survivors and Effects on Cardiometabolic Disease Risk and Inflammaging Biomarkers: A Systematic Review. [PDF]

Adv Nutr
Cares K, Bryner A, DiPiazza B, Chakos K, Schmidt ML, Gabel K.   +5 more
europepmc   +1 more source