Results 21 to 30 of about 17,832 (233)

Systems medicine of inflammaging [PDF]

Briefings in Bioinformatics, 2015
Systems Medicine (SM) can be defined as an extension of Systems Biology (SB) to Clinical-Epidemiological disciplines through a shifting paradigm, starting from a cellular, toward a patient centered framework. According to this vision, the three pillars of SM are Biomedical hypotheses, experimental data, mainly achieved by Omics technologies and ...
CASTELLANI, GASTONE, MENICHETTI, GIULIA, GARAGNANI, PAOLO, BACALINI, MARIA GIULIA, PIRAZZINI, CHIARA, FRANCESCHI, CLAUDIO, Collino, Sebastiano, SALA, CLAUDIA, REMONDINI, DANIEL, GIAMPIERI, ENRICO, Mosca, Ettore, BERSANELLI, MATTEO, VITALI, SILVIA, Do Valle, Italo Faria, Liò, Pietro, Milanesi, Luciano   +15 more
openaire   +5 more sources

Alzheimer’s Disease and Inflammaging

Brain Sciences, 2022
Alzheimer’s disease is one of the most common age-related neurodegenerative disorders. The main theory of Alzheimer’s disease progress is the amyloid-β cascade hypothesis. However, the initial mechanisms of insoluble forms of amyloid-β formation and hyperphosphorylated tau protein in neurons remain unclear.
Anna Kosyreva, Alexandra Sentyabreva, Ivan Tsvetkov, Olga Makarova   +3 more
openaire   +3 more sources

Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes

iScience, 2021
Summary: Inflammaging is associated with an increased risk of chronic disease. Monocytes are the principal immune cells for the production of inflammatory cytokines and contribute to inflammaging in the elderly.
Ming Wang, Yan Yan, Zhengguo Zhang, Xiaohan Yao, Xixi Duan, Ziming Jiang, Junfeng An, Peiguo Zheng, Yijie Han, Hao Wu, Zhaoqing Wang, Rainer Glauben, Zhihai Qin   +12 more
doaj   +1 more source

Inflammaging and the Lung [PDF]

Clinics in Geriatric Medicine, 2017
With the coming of the "silver tsunami," expanding the knowledge about how various intrinsic and extrinsic factors affect the immune system in the elderly is timely and of immediate clinical need. The global population is increasing in age. By the year 2030, more than 20% of the population of the United States will be older than 65 years of age.
Elizabeth J, Kovacs, Devin M, Boe, Lisbeth A, Boule, Brenda J, Curtis   +3 more
openaire   +2 more sources

Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging

Immunity & Ageing, 2023
Background Chronic, low-grade inflammation, also termed ‘inflammaging’, has been linked to the development of some aging-associated disorders. Recent studies suggest that inflammaging is attributable to aging-associated epidermal dysfunction.
Bin Yang, Chengzhi Lv, Li Ye, Zhen Wang, Yoon Kim, Wenhai Luo, Peter M. Elias, Mao-Qiang Man   +7 more
doaj   +1 more source

Inflammation and premature aging in advanced chronic kidney disease [PDF]

, 2017
Systemic inflammation in end-stage renal disease (ESRD) is an established risk factor for mortality and a catalyst for other complications which are related to a premature aging phenotype, including muscle wasting, vascular calcification and other forms ...
Casper G. Schalkwijk, Frank M. van der Sande, Jeroen P. Kooman, Kaysen GA, Len A. Usvyat, Marijke J. Dekker, Paul G. Shiels, Peter Kotanko, Peter Stenvinkel, Witko-Sarsat V   +9 more
core   +1 more source

Neuro-Inflammaging and Psychopathological Distress

Biomedicines, 2022
Inflammaging is a low degree of chronic and systemic tissue inflammation associated with aging, and is intimately linked to pro-inflammatory mediators. These substances are involved in the pathogenesis of chronic inflammatory diseases and related psychopathological symptoms.
Giuseppe Murdaca, Francesca Paladin, Marco Casciaro, Carmelo Mario Vicario, Sebastiano Gangemi, Gabriella Martino   +5 more
openaire   +5 more sources

The natural history of periodontal disease—Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP)

Periodontology 2000, EarlyView., 2023
Abstract In this descriptive analysis of the 21‐year follow‐up data from the SHIP‐START cohort and the 7‐year follow‐up data from the SHIP‐TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in
Thomas Kocher, Peter Meisel, Reiner Biffar, Henry Völzke, Birte Holtfreter   +4 more
wiley   +1 more source

Inflammaging and cardiovascular disease: Management by medicinal plants [PDF]

, 2016
Background In aging, a host of molecular and cellular changes occur which accelerate alteration and progression of inflammatory diseases. These conditions in the elderly people cause appearance of a phenomenon which has been denoted as “inflammaging ...
Asgary, Sedigheh., Bahmani, Mahmoud., Rafieian-Kopaei, Mahmoud., Shayganni, Erfaneh.   +3 more
core   +2 more sources

Serum Biochemical Phenotypes in the Domestic Dog [PDF]

, 2016
The serum or plasma biochemical profile is essential in the diagnosis and monitoring of systemic disease in veterinary medicine, but current reference intervals typically take no account of breed-specific differences.
Chang, Y M, Garden, O A, Hadox, E, Szladovits, B   +3 more
core   +3 more sources