Results 31 to 40 of about 17,832 (233)
Cells, 2022 A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and ...
Vladimir Khavinson +4 more
doaj +1 more source
Klotho controls the brain-immune system interface in the choroid plexus. [PDF]
, 2018 Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn +7 more
core +1 more source
Melatonin and brain inflammaging [PDF]
Progress in Neurobiology, 2015 Melatonin is known to possess several properties of value for healthy aging, as a direct and indirect antioxidant, protectant and modulator of mitochondrial function, antiexcitotoxic agent, enhancer of circadian amplitudes, immune modulator and neuroprotectant.
Hardeland, Rüdiger +3 more
openaire +3 more sources
Siglec receptors impact mammalian lifespan by modulating oxidative stress. [PDF]
, 2015 Aging is a multifactorial process that includes the lifelong accumulation of molecular damage, leading to age-related frailty, disability and disease, and eventually death. In this study, we report evidence of a significant correlation between the number
Fu, Xiaoming +16 more
core +1 more source
Bone regeneration in inflammation with aging and cell-based immunomodulatory therapy
Inflammation and Regeneration, 2023 Aging of the global population increases the incidence of osteoporosis and associated fragility fractures, significantly impacting patient quality of life and healthcare costs. The acute inflammatory reaction is essential to initiate healing after injury.
Junichi Kushioka +8 more
doaj +1 more source
Cellular Mechanisms of Inflammaging and Periodontal Disease
Frontiers in Dental Medicine, 2022 Increased age is associated with an increased prevalence of chronic inflammatory diseases and conditions. The term inflammaging has been used to describe the age-related changes to the immune response that results in a chronic and elevated inflammatory ...
Daniel Clark +2 more
doaj +1 more source
Systemic inflammation, body composition, and physical performance in old community-dwellers [PDF]
, 2017 Background Chronic inflammation, changes in body composition, and declining physical function are hallmarks of the ageing process. The aim of the present study was to provide a preliminary characterisation of the relationship among these age-related ...
Addison +33 more
core +2 more sources
lncRNA-Triggered Macrophage Inflammaging Deteriorates Age-Related Diseases
Mediators of Inflammation, 2019 Aging and age-related diseases (ARDs) share basic mechanisms largely involving inflammation. A chronic, low-grade, subclinical inflammation called inflammaging occurs during aging.
Lulingxiao Nie +4 more
doaj +1 more source
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Immunity & Ageing, 2020 Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder.
Rachel Thomas, Weikan Wang, Dong-Ming Su
doaj +1 more source
Rusty microglia: trainers of innate immunity in Alzheimer's disease [PDF]
, 2018 Alzheimer's disease, the most common form of dementia, is marked by progressive cognitive and functional impairment believed to reflect synaptic and neuronal loss.
Adonis Sfera +6 more
core +2 more sources