Results 71 to 80 of about 17,832 (233)

Targeting Efferocytosis in Inflammaging

Annual Review of Pharmacology and Toxicology
Rapid removal of apoptotic cells by phagocytes, a process known as efferocytosis, is key for the maintenance of tissue homeostasis, the resolution of inflammation, and tissue repair. However, impaired efferocytosis can result in the accumulation of apoptotic cells, subsequently triggering sterile inflammation through the release of endogenous factors ...
Poon, Ivan K H, Ravichandran, Kodi S
openaire   +3 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Cardiovascular inflammaging: Mechanisms, consequences, and therapeutic perspectives

Cell Reports Medicine
Summary: Both aging and systemic inflammation are major risk factors for cardiovascular disease. This review summarizes the interrelationship of aging and inflammation—known as inflammaging—and the consequences for cardiovascular health.
Luke Spray, Gavin Richardson, Judith Haendeler, Joachim Altschmied, Valencia Rumampouw, Sienna B. Wallis, Georgios Georgiopoulos, Stephen White, Amanda Unsworth, Konstantinos Stellos, Simon Tual-Chalot, Ioakim Spyridopoulos   +11 more
doaj   +1 more source

Aging Relevant Metabolite Itaconate Inhibits Inflammatory Bone Loss

Frontiers in Endocrinology, 2022
Progressive bone loss during aging makes osteoporosis one of the most common and life impacting conditions in geriatric populations. The bone homeostasis is maintained through persistent remodeling mediated by bone-forming osteoblast and bone-resorbing ...
Yuting Wang, Song Li, Liming Zhao, Peng Cheng, Jian Liu, Fengjing Guo, Jun Xiao, Wentao Zhu, Anmin Chen   +8 more
doaj   +1 more source

Differences in Proinflammatory Cytokines and Monocyte Subtypes in Older as Compared With Younger Kidney Transplant Recipients. [PDF]

, 2018
Background:The number of elderly patients with end-stage kidney disease requiring kidney transplantation continues to grow. Evaluation of healthy older adults has revealed proinflammatory changes in the immune system, which are posited to contribute to ...
Abdalla, Basmah, Bunnapradist, Suphamai, Danovitch, Gabriel, Groysberg, Victoria, Korin, Yael, Liang, Emily C, Lum, Erik, Pham, Phuong-Thu, Reed, Elaine F, Rossetti, Maura, Schaenman, Joanna, Sidwell, Tiffany, Sunga, Gema, Vangala, Sitaram   +13 more
core   +1 more source

Age-related biomarkers can be modulated by diet in the rat

, 2011
This study seeks to establish the normal serum concentrations of biochemical markers related to nutrition, inflammation and disease, and to investigate how the levels change with age and diet in the rat.
Evans, Karen, MacQueen, Hilary Anne, Sadler, Dawn Angela, Walker, Ian, Wassif, Wassif Samuel   +4 more
core   +1 more source

Menopause and adipose tissue : miR-19a-3p is sensitive to hormonal replacement [PDF]

, 2017
Tissue-specific effects of 17 beta-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women.
Aukee, Pauliina, Capri, Miriam, Franceschi, Claudio, Kangas, Reeta, Kaprio, Jaakko, Kovanen, Vuokko, Laakkonen, Eija K., Lanzarini, Catia, Morsiani, Cristina, Pizza, Grazia, Sipilä, Sarianna   +10 more
core   +1 more source

Shortened outreach periodontal therapy in nursing home residents with periodontitis: A randomized controlled trial

Journal of Periodontology, EarlyView.
Abstract Background We examined the clinical effectiveness of shortened outreach periodontal therapy for 3 months in nursing home residents with periodontitis versus controls (no therapy). Methods Nursing home residents with periodontitis were randomly assigned to either (a) one‐time, shortened outreach periodontal therapy adapted to German statutory ...
Anna G. Barbe, Dalia Beck, Martin Hellmich, Max von Kohout, Sonja H. M. Derman, Dirk Bleiel   +5 more
wiley   +1 more source

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +1 more source

Diagnostic modulation of subgingival proteomic biomarkers by age and smoking habits in periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Although age and smoking influence the periodontal proteome, their impact on subgingival biomarkers for diagnosing periodontitis remains unclear. This multicenter study assessed their influence on subgingival proteins for disease detection.
Triana Blanco‐Pintos, Alba Regueira‐Iglesias, Berta Suárez‐Rodríguez, Alba Sánchez‐Barco, Iryna Kuz, Marta Relvas, Susana Belén Bravo, Carlos Balsa‐Castro, Inmaculada Tomás   +8 more
wiley   +1 more source