Results 41 to 50 of about 188,554 (379)

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Inflammasome Activation by ATP Enhances Citrobacter rodentium Clearance through ROS Generation

Cellular Physiology and Biochemistry, 2017
Background: Nod-like receptor family, pyrin domain containing 3 (NLRP3) is an important cytosolic sensor of cellular stress and infection. Once activated, NLRP3 forms a multiprotein complex (inflammasome) that triggers the maturation and secretion of ...
Michael Bording-Jorgensen, Misagh Alipour, Eytan Wine, Ghazal Danesh   +3 more
doaj   +1 more source

C646 Protects Against DSS-Induced Colitis Model by Targeting NLRP3 Inflammasome

Frontiers in Pharmacology, 2021
Numerous pieces of evidence have identified that the NLRP3 inflammasome plays a pivotal role in the development and pathogenesis of colitis. Targeting the NLRP3 inflammasome represents a potential therapeutic treatment.
Xueming Xu, Jing Li, Xiuyan Long, Sifan Tao, Xiaoyu Yu, Xixian Ruan, Kai Zhao, Li Tian   +7 more
doaj   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources

Inflammasome Activation in Bovine Peripheral Blood-Derived Macrophages Is Associated with Actin Rearrangement

Animals, 2020
Inflammation is critical for infection control and acts as an arsenal defense mechanism against invading microbes through activation of the host immune system.
Amin Tahoun, Kirsty Jensen, Hanem El-Sharkawy, David Gally, Amira M. Rizk, Jamaan Ajarem, Ahmed Allam, Ayman M. Mahmoud   +7 more
doaj   +1 more source

Interaction between the inflammasome and commensal microorganisms in gastrointestinal health and disease

EMBO Molecular Medicine, 2021
The inflammasome is a cytosolic multiprotein complex that plays a crucial role in inflammation and cell death. The sensor proteins in the inflammasome complex detect various microbial and endogenous stimuli, leading to subsequent caspase activation.
Daisuke Watanabe, Yijie Guo, Nobuhiko Kamada   +2 more
doaj   +1 more source

Double-walled carbon nanotubes trigger IL-1β release in human monocytes through Nlrp3 inflammasome activation [PDF]

, 2012
Because of their outstanding physical properties, carbon nanotubes (CNTs) are promising new materials in the field of nanotechnology. It is therefore imperative to assess their adverse effects on human health.
Authier, Hélène, Bernad, José, Béraud, Maryse, Coste, Agnès, Dardenne, Christophe, Flahaut, Emmanuel, Lefèvre, Lise, Meunier, Etienne, Olagnier, David, Pipy, Bernard   +9 more
core   +3 more sources

AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection

Virulence, 2022
NLRP3 inflammasome mainly controls interleukin-1β (IL-1β) secretion, leading to cell death called pyroptosis constituting a major antiviral host defense and inflammatory diseases upon viral infection.
Pin Wan, Simeng Zhang, Zhihui Ruan, Xueli Liu, Ge Yang, Yaling Jia, Yongkui Li, Pan Pan, Wenbiao Wang, Geng Li, Xulin Chen, Zhixin Liu, Qiwei Zhang, Zhen Luo, Jianguo Wu   +14 more
doaj   +1 more source

IKKα negatively regulates ASC-dependent inflammasome activation. [PDF]

, 2014
The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines.
Alnemri, Emad S, Bulek, Katarzyna, Dubyak, George, Fitzgerald, Katherine A, Franchi, Luigi, Gulen, Muhammet F, Herjan, Tomasz, Hu, Yinling, Karin, Michael, Klinman, Dennis, Li, Xiaoxia, Martin, Bradley N, Narla, Goutham, Nuñez, Gabriel, Sato, Takashi, Thomas, James, Wang, Chenhui, Willette-Brown, Jami, Zhong, Xiao-Ping, Zhou, Hao   +19 more
core   +1 more source

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source