Results 41 to 50 of about 56,139 (234)
The AIM2 inflammasome is activated in astrocytes during the late phase of EAE
JCI Insight, 2022 Inflammasomes are a class of innate immune signaling platforms that activate in response to an array of cellular damage and pathogens. Inflammasomes promote inflammation under many circumstances to enhance immunity against pathogens and inflammatory ...
William E. Barclay +8 more
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Frontiers in Cellular Neuroscience, 2022 Recombinant human erythropoietin (rhEPO) has been shown to exert anti-apoptotic and anti-inflammatory effects after cerebral ischemia. Inflammatory cytokines interleukin-1β and -18 (IL-1β and IL-18) are crucial mediators of apoptosis and are maturated by
Eren Arik +11 more
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Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
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NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. [PDF]
, 2017 Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling pathways that cause these diseases remain poorly understood ...
Nichols, Randilea D +2 more
core +2 more sources
Journal of Molecular Biology, 2022 The concept of non-self recognition through germ-line encoded pattern recognition receptors (PRRs) has been well-established for professional innate immune cells. However, there is growing evidence that also T cells employ PRRs and associated effector functions in response to certain non-self or damage signals.
Andreas Linder, Veit Hornung
openaire +2 more sources
Inflammasome activation by viral infection: mechanisms of activation and regulation
Frontiers in Microbiology, 2023 Viral diseases are the most common problems threatening human health, livestock, and poultry industries worldwide. Viral infection is a complex and competitive dynamic biological process between a virus and a host/target cell.
Wen Shi +14 more
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PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling [PDF]
Biochemical Society Transactions, 2021 Inflammasomes are protein complexes in the innate immune system that regulate the production of pro-inflammatory cytokines and inflammatory cell death. Inflammasome activation and subsequent cell death often occur within minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of ...
McKee, CM +3 more
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Non-Coding RNAs: Master Regulators of Inflammasomes in Inflammatory Diseases
Journal of Inflammation Research, 2021 Wei Wang, Ni Yang, Yu-Hang Yang, Ri Wen, Chun-Feng Liu, Tie-Ning Zhang Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of ChinaCorrespondence: Chun-Feng Liu; Tie-Ning ZhangDepartment of Pediatrics ...
Wang W +5 more
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NLRP2 controls age-associated maternal fertility [PDF]
, 2016 Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are well-known for their key roles in the immune system. Ectopically expressed NLRP2 in immortalized cell lines assembles an inflammasome and inhibits activation of the proinflammatory ...
Agostini +24 more
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Emerging mechanisms and functions of inflammasome complexes in teleost fish
Frontiers in Immunology, 2023 Inflammasomes are multiprotein complexes, which are assembled in response to a diverse range of exogenous pathogens and endogenous danger signals, leading to produce pro-inflammatory cytokines and induce pyroptotic cell death.
Ming Xian Chang +2 more
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