Results 61 to 70 of about 90,432 (374)
Complementing the inflammasome [PDF]
Immunology, 2016 SummaryThe innate immune system is an ancient surveillance system able to sense microbial invaders as well as aberrations in normal cell function. No longer viewed as a static and non‐specific part of immunity, the innate immune system employs a plethora of specialized pattern recognition sensors to monitor and achieve homeostasis; these include the ...
Martha Triantafilou +3 more
openaire +3 more sources
Assembly and Architecture of NLR Resistosomes and Inflammasomes.
Annual Review of Biophysics, 2022 Nucleotide-binding and leucine-rich repeat (NLR) proteins are critical intracellular immune receptors in both animals and plants. Perception of pathogen-derived or stress-associated signals induces NLR oligomerization to form multiprotein complexes ...
Zehan Hu, J. Chai
semanticscholar +1 more source
PHOrming the inflammasome: phosphorylation is a critical switch in inflammasome signalling [PDF]
Biochemical Society Transactions, 2021 Inflammasomes are protein complexes in the innate immune system that regulate the production of pro-inflammatory cytokines and inflammatory cell death. Inflammasome activation and subsequent cell death often occur within minutes to an hour, so the pathway must be dynamically controlled to prevent excessive inflammation and the development of ...
McKee, CM +3 more
openaire +6 more sources
Inflammasome activation by viral infection: mechanisms of activation and regulation
Frontiers in Microbiology, 2023 Viral diseases are the most common problems threatening human health, livestock, and poultry industries worldwide. Viral infection is a complex and competitive dynamic biological process between a virus and a host/target cell.
Wen Shi +14 more
doaj +1 more source
Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]
, 2017 Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio +10 more
core +1 more source
Inflammasomes in Alveolar Bone Loss
Frontiers in Immunology, 2021 Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict synchronization of bone resorption and formation, which maintains ...
Yang Li, J. Ling, Qianzhou Jiang
semanticscholar +1 more source
Journal of Molecular Biology, 2022 The concept of non-self recognition through germ-line encoded pattern recognition receptors (PRRs) has been well-established for professional innate immune cells. However, there is growing evidence that also T cells employ PRRs and associated effector functions in response to certain non-self or damage signals.
Andreas Linder, Veit Hornung
openaire +2 more sources
One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
core +1 more source
Inflammasomes and Their Activation [PDF]
Critical Reviews™ in Immunology, 2010 The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition ...
Sonal Khare +3 more
openaire +3 more sources
Mechanism of inflammasomes in cancer and targeted therapies
Frontiers in Oncology, 2023 Inflammasomes, composed of the nucleotide-binding oligomerization domain(NOD)-like receptors (NLRs), are immune-functional protein multimers that are closely linked to the host defense mechanism.
Qingdan Gu +3 more
doaj +1 more source