Results 61 to 70 of about 47,495 (266)
The significance of inflammasome activation during each phase of wound healing [PDF]
Exploration of MedicineThe inflammasome is a critical inflammatory signaling cascade. Diverse events, including infections or tissue damage, activate it. It is essential in regulating the early stages of wound healing but is overall downregulated in the later stages.
Carol M. Artlett
doaj +1 more source
TLR9 regulates NLRP3 inflammasome activation via the NF-kB signaling pathway in diabetic nephropathy
, 2022 Jin-feng Shen +4 more
openalex +1 more source
Advanced Science, EarlyView.Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu +12 more
wiley +1 more source
Time‐dependent dual effect of NLRP3 inflammasome in brain ischaemia
, 2021 Alejandra Palomino‐Antolín +10 more
openalex +2 more sources
POS0236 ROLE OF NLRP3 INFLAMMASOME-DERIVED ASC SPECKS IN ADULT-ONSET STILL’S DISEASE [PDF]
, 2023 J. Topping +9 more
openalex +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
Deciphering Inflammasome Mechanisms in Periodontal Diseases: A Review
Archives of Medicine and Health SciencesInflammasomes are complex multimeric protein molecules that play a central role in orchestrating the inflammatory response within periodontal tissues.
Himani Sharma +2 more
doaj +1 more source
Resveratrol Attenuates Exercise-induced Acute Kidney Injury by Inhibiting NLRP3 Inflammasome-mediated Renal Tubular Pyroptosis [PDF]
, 2023 Li Fang +5 more
openalex +1 more source
Advanced Science, EarlyView.Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He +8 more
wiley +1 more source
METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation
Advanced Science, EarlyView.METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li +19 more
wiley +1 more source