Results 61 to 70 of about 56,139 (234)
Innate immunity and neuroinflammation [PDF]
, 2013 Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
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Inflammasomes and Their Activation [PDF]
Critical Reviews™ in Immunology, 2010 The innate immune system relies on the recognition of pathogens by pattern recognition receptors as a first line of defense and to initiate the adaptive immune response. Substantial progress has been made in defining the role of Nod (nucleotide-binding oligimerization domain)-like receptors and AIM2 (absent in melanoma 2) as pattern recognition ...
Sonal Khare +3 more
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From Inflammation to Prostate Cancer: The Role of Inflammasomes
Advances in Urology, 2016 Inflammation-associated studies entice specific attention due to inflammation’s role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized.
Dev Karan, Seema Dubey
doaj +1 more source
Frontiers in Physiology, 2022 Tangzhiqing formula (TZQ) is a traditional Chinese medicine prescribed to treat glucose and lipid metabolism disorders. A significant effect of TZQ on diabetes and hyperlipidemia has been demonstrated, but its effect on atherosclerosis (AS) remains ...
Rui Chen +11 more
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A single-cell mathematical model of SARS-CoV-2 induced pyroptosis and the effects of anti-inflammatory intervention [PDF]
arXiv, 2020 Pyroptosis is an inflammatory mode of cell death that can contribute to the cytokine storm associated with severe cases of coronavirus disease 2019 (COVID-19). The formation of the NLRP3 inflammasome is central to pyroptosis, which may be induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
arxiv
Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]
, 2017 Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio +10 more
core +1 more source
Molecular Immunology, 2017 Innate immune responses act as first line defences upon exposure to potentially noxious stimuli. The innate immune system has evolved numerous intracellular and extracellular receptors that undertake surveillance for potentially damaging particulates.
Pinkerton, James W. +9 more
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The crystal-induced activation of NLRP3 inflammasomes in atherosclerosis
Inflammation and Regeneration, 2017 Atherosclerosis is an inflammatory disease, which is accompanied by the deposition of cholesterol-rich lipids and the infiltration of macrophages. Other well-known features of atherosclerotic lesions include the deposition of cholesterol crystals and ...
Tadayoshi Karasawa, Masafumi Takahashi
doaj +1 more source
Pyroptosis: Physiological roles in viral infection [PDF]
arXiv, 2020 The current review focuses on important aspects of pyroptosis, such as morphological features of inflammasomes, as well as on knowledge about coronavirus infection mechanisms and the association between SARS-CoV-2 infection and cell pyroptosis. The application of immunomodulation therapies to Covid-19 patients is the most promising treatment under ...
arxiv
Immunology, 2021 SummaryInflammasomes are generally thought of as large protein complexes that assemble in the cytosol in response to danger such as tissue damage or infection; once activated, they trigger production of inflammatory cytokines and drive cells towards a pro‐inflammatory death – termed pyroptosis.
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