Results 1 to 10 of about 428,528 (325)

PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background. [PDF]

, 2012
Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD).
Beigel, Florian, Brand, Stephan, Czamara, Darina, Diegelmann, Julia, Friedrich, Matthias, Glas, Jürgen, Göke, Burkhard, Karbalai, Nazanin, Ochsenkühn, Thomas, Olszak, Torsten, Seiderer, Julia, Stallhofer, Johannes, Steib, Christian, Tillack, Cornelia, Wagner, Johanna, Wetzke, Martin   +15 more
core   +14 more sources

Perceived Stigma and Self-Efficacy of Patients With Inflammatory Bowel Disease-Related Stoma in China: A Cross-Sectional Study

Frontiers in Medicine, 2022
BackgroundPatients with inflammatory bowel disease (IBD)-related stoma face physical, psychological, and social adjustment challenges. However, knowledge about stigmatization and self-management, which is important for clinical care and patient education
Yuting Wang, Shuyan Li, Jianfeng Gong, Lei Cao, Dingting Xu, Qiao Yu, Xiaoying Wang, Yan Chen   +7 more
doaj   +1 more source

Evaluation of changes in intestinal microbiota in Crohn’s disease patients after anti-TNF alpha treatment

Scientific Reports, 2021
Intestinal dysbiosis is key in the onset and development of Crohn’s disease (CD). We evaluated the microbiota changes in CD patients before and after a six-month anti-TNF treatment, comparing these changes with the microbiota of healthy subjects.
Laura Sanchis-Artero, Juan Francisco Martínez-Blanch, Sergio Manresa-Vera, Ernesto Cortés-Castell, Marina Valls-Gandia, Marisa Iborra, Jose Maria Paredes-Arquiola, Maia Boscá-Watts, Jose Maria Huguet, Rafael Gil-Borrás, Josefa Rodríguez-Morales, Xavier Cortés-Rizo   +11 more
doaj   +1 more source

Recall of Care Objectives by Patients with Inflammatory Bowel Diseases

Gastrointestinal Disorders, 2022
The management of IBD is highly complex, given the heterogeneity of treatment plans for an equally diverse patient population. Given the intricacy of treatment, improved health literacy may be associated with better outcomes.
Aria Zand, Shelley Shi, Dominic Nguyen, Brian Kim, Eric Esrailian, Daniel Hommes   +5 more
doaj   +1 more source

Advances in Mobile Health for Inflammatory Bowel Disease

Diagnostics, 2022
Mobile health has the potential to transform the management of chronic illnesses, expanding treatment from a purely clinic-based approach to a more patient-centered delivery of care.
Ellen J. Spartz, Lauren DeDecker, Danny Le, Laleh Jalilian, Berkeley N. Limketkai   +4 more
doaj   +1 more source

DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier InjurySummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: Tumor necrosis factor (TNF) superfamily member tumor necrosis factor–like protein 1A (TL1A) has been associated with the susceptibility and severity of inflammatory bowel diseases. However, the function of the tumor necrosis factor–
Yosuke Shimodaira, Shyam K. More, Hussein Hamade, Anna Y. Blackwood, Jay P. Abraham, Lisa S. Thomas, Jordan H. Miller, Dalton T. Stamps, Sofi L. Castanon, Noam Jacob, Connie W.Y. Ha, Suzanne Devkota, David Q. Shih, Stephan R. Targan, Kathrin S. Michelsen   +14 more
doaj   +1 more source

The effects of inflammatory bowel disease on caregivers: significant burden and loss of productivity

BMC Health Services Research, 2020
Background Caregiver burden is the emotional, physical, practical, and/or financial burden associated with taking care of a patient with a chronic condition.
Aria Zand, Brian J. Kim, Welmoed K. van Deen, Zachary Stokes, Anya Platt, Shelby O’Hara, Harrison Khong, Daniel W. Hommes   +7 more
doaj   +1 more source

Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome

Genome Medicine, 2022
Background Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected controls. However, the impact of inflammation and underlying genetic risk on these microbial profiles and
Jonathan P. Jacobs, Maryam Goudarzi, Venu Lagishetty, Dalin Li, Tytus Mak, Maomeng Tong, Paul Ruegger, Talin Haritunians, Carol Landers, Philip Fleshner, Eric Vasiliauskas, Andrew Ippoliti, Gil Melmed, David Shih, Stephan Targan, James Borneman, Albert J. Fornace, Dermot P. B. McGovern, Jonathan Braun   +18 more
doaj   +1 more source

Development and evaluation of a risk assessment tool to improve clinical triage accuracy for colonoscopic investigations

BMC Cancer, 2018
Background Gastroenterology Departments at hospitals within Australia receive thousands of General Practitioner (GP)-referral letters for gastrointestinal investigations every month. Many of these requests are for colonoscopy. This study aims to evaluate
Anton R. Lord, Lisa A. Simms, Allison Brown, Katherine Hanigan, Krupa Krishnaprasad, Belinda Schouten, Anthony R. Croft, Mark N. Appleyard, Graham L. Radford-Smith   +8 more
doaj   +1 more source

A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and AutophagySummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Chronic bowel inflammation increases the risk of colon cancer; colitis-associated cancer (CAC). Thiopurine treatments are associated with a reduction in dysplasia and CAC in inflammatory bowel disease (IBD).
Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J. Lucke, David P. Fairlie, Michael A. McGuckin, Timothy H. Florin, Jakob Begun   +17 more
doaj   +1 more source