ILC3 function as a double-edged sword in inflammatory bowel diseases
Cell Death and Disease, 2019 Inflammatory bowel diseases (IBD), composed mainly of Crohn’s disease (CD) and ulcerative colitis (UC), are strongly implicated in the development of intestinal inflammation lesions. Its exact etiology and pathogenesis are still undetermined.
Boning Zeng +5 more
semanticscholar +1 more source
Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer
Molecular Oncology, EarlyView.This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu +7 more
wiley +1 more source
Nutritional impact of inflammatory bowel diseases on children and adolescents* *Study conducted at the Service of Pediatric Gastroenterology and Hepatology (Complexo HUPES-CPPHO) and Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, BA, Brazil. [PDF]
OBJECTIVETo perform a sistematiy review of the literature about the nutritional impact of inflammatory bowel diseases in children and adolescents.DATA SOURCESA systematic review was performed using PubMed/MEDLINE, LILACS and SciELO databases, with ...
dos Santos, Gilton Marques +2 more
core +1 more source
A Turing mechanism in order to explain the patchy nature of Crohn's disease [PDF]
arXiv, 2020 Crohn's disease is an inflammatory bowel disease (IBD) that is not well understood. In particular, unlike other IBDs, the inflamed parts of the intestine compromise deep layers of the tissue and are not continuous but separated and distributed through the whole gastrointestinal tract, displaying a patchy inflammatory pattern.
arxiv
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Clinical and Translational MedicineBackground Mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) have emerged as key regulators of intercellular communication, orchestrating essential biological processes by delivering bioactive cargoes to target cells.
Laura Clua‐Ferré +5 more
doaj +1 more source
Utility of serological markers in inflammatory bowel diseases: Gadget or magic? [PDF]
, 2007 The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Although anti-Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely ...
Altorjay, István +3 more
core +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Leukocytapheresis in patients with inflammatory bowel diseases
Gastroenterology Review, 2021 Leukocytapheresis, a blood purification therapy, exerts anti-inflammatory effects by removing activated leukocytes from the peripheral blood through extracorporeal circulation.
Małgorzata Woźniak +3 more
doaj +1 more source
Optimal Estimation of Bacterial Growth Rates Based on Permuted Monotone Matrix [PDF]
Biometrika (2020), 2019 Motivated by the problem of estimating the bacterial growth rates for genome assemblies from shotgun metagenomic data, we consider the permuted monotone matrix model $Y=\Theta\Pi+Z$, where $Y\in \mathbb{R}^{n\times p}$ is observed, $\Theta\in \mathbb{R}^{n\times p}$ is an unknown approximately rank-one signal matrix with monotone rows, $\Pi \in \mathbb{
arxiv +1 more source