Results 91 to 100 of about 1,145,138 (308)

Heat shock proteins in tendinopathy: novel molecular regulators [PDF]

, 2012
Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Neal L. Millar, George A. C. Murrell, Millar, N.L., Murrell, G.A.C.   +3 more
core   +1 more source

Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide [PDF]

, 2011
We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown
Ciara M. Finucane, Y. K. Stella Man, Danielle DiCara, Rita Jones, Ahuva Nissim, Stephen J. Mather, Taher E. I. Taher, Michele Bombardieri, Costantino Pitzalis, Yuti Chernajovsky, Sarah E. Wythe   +10 more
core   +1 more source

Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis [PDF]

, 2004
Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next ...
Bannerman, Douglas, Goff, JP, Goff, Jesse P, Lippolis, JD, John D. Lippolis, Paape, Max, Bannerman, Douglas D, Paape, Max J, Kimura, K, Jayne C. Hope, Hope, Jayne C, Kimura, Kayoko, Lippolis, John D, Douglas D. Bannerman, Max J. Paape, Lippolis, John, Hope, Jayne, Kayoko Kimura, Hope, Jayne; id_orcid, Jesse P. Goff, Goff, Jesse   +20 more
core   +1 more source

Causal Correlations Between Plasma Metabolites, Inflammatory Proteins, and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization and Bioinformatics-Based Investigation [PDF]

Shurui Cao,* Yongqi Gu,* Guye Lu, Lizhen Zhu, Shumin Feng, Tao Bian Department of Respiratory Medicine, Wuxi People’s Hospital, Wuxi Medical Center, The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Nanjing Medical University ...
Lu G, Gu Y, Zhu L, Cao S, Feng S, Bian T
core   +1 more source

Optimal combinations of acute phase proteins for detecting infectious disease in pigs [PDF]

, 2011
Peer ...
Mathilda JM Toussaint, Eckersall, P.D., Anders Stockmarr, Campbell, Fiona M, Rakel Carpintero, Piñeiro, M., Toussaint, Mathilda J.M., Sorensen, N., Eckersall, P. David, Campbell, F.M., Nanna Sorensen, Campbell, Fiona Margaret, Toussaint, M.J.M., Carpintero, Rakel, Fiona M Campbell, Lampreave, F., Skall Sorensen, Nanna, P Eckersall, Carpintero, R., Erik Gruys, Piñeiro, Matilde, Heegaard, P.M.H., Fermin Lampreave, Stockmarr, A., Toussaint, Mathilda JM, Lampreave, Fermin, Sørensen, Nanna Skall, Matilde Piñeiro, Heegaard, Peter M. H., Peter MH Heegaard, Gruys, Erik, Gruys, E., Eckersall, P David, Stockmarr, Anders   +33 more
core   +1 more source

Mechanisms by which interleukin-4 suppresses inflammatory cytokine production by activated human monocytes [PDF]

, 2011
Improving understanding of how inflammatory responses by monocytes and macrophages are regulated may aid in the development of more targeted therapies for chronic inflammatory disease.
Woodward, Eleanor
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Inflammatory protein mediators linking gut microbiota to degenerative lumbar spine disorders: cross-disease genetic evidence

Frontiers in Immunology
BackgroundDegenerative lumbar spine disorders (DLSD), including intervertebral disc disorders (IDD), degenerative spondylolisthesis, and lumbar spinal stenosis (LSS), are major contributors to low back pain and disability.
Yongfu Lou, Yongfu Lou, Daoyi Ma, Daoyi Ma, Qingquan Gan, Qingquan Gan, Xianyue Xu, Xianyue Xu, Yiming Xiao, Yiming Xiao, Junzhuo Wang, Junzhuo Wang, Zhibing Li, Zhibing Li, Tao Zhang, Tao Zhang, Lei Qi, Shiqing Feng, Shiqing Feng, Shiqing Feng, Shiqing Feng   +20 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Causality Between 91 Circulating Inflammatory Proteins and Various Asthma Phenotypes: A Mendelian Randomization Study [PDF]

Shiyao Zhang,1 Xiuying Zhang,2 Chenghao Wei,1 Lai Zhang,1 Zhaoyang Li1 1Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People’s Republic of China; 2The First Affiliated Hospital of Liaoning University of Traditional Chinese ...
Li Z, Zhang X, Wei C, Zhang L, Zhang S
core   +1 more source