Results 111 to 120 of about 1,145,138 (308)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A variant form of the human Deleted in Malignant Brain Tumor 1 (DMBT1) gene shows increased expression in inflammatory bowel diseases and interacts with dimeric trefoil factor 3 (TFF3) [PDF]

, 2013
The protein deleted in malignant brain tumors (DMBT1) and the trefoil factor (TFF) proteins have all been proposed to have roles in epithelial cell growth and cell differentiation and shown to be up regulated in inflammatory bowel diseases.
Tornoe, Ida, Madsen, Jens, Fenger Claus, Sorensen, Grith Lykke; id_orcid, Thim, Lars, Nielsen, Ole, Sorensen, Grith Lykke, Ole Nielsen, Ole Nielsen (326640), Uffe Holmskov, Uffe Holmskov (153599), Lars Thim, Claus Fenger (412795), Holmskov, Uffe, Jens Madsen (391091), Sorensen Grith Lykke, Holmskov Uffe, Tornøe Ida, Madsen Jens, Jan Mollenhauer (133637), Ida Tornøe (412793), Mollenhauer Jan, Fenger, Claus, Ida Tornøe, Grith Lykke Sorensen (412792), Nielsen Ole, Tornøe, Ida, Grith Lykke Sorensen, Claus Fenger, Nielsen, Ole Stig, Mollenhauer, Jan, Jens Madsen, Thim Lars, Jan Mollenhauer, Lars Thim (412794)   +34 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J, Venero, JL, Rodhe, J,, Rodhe, Johanna, Joseph, B, Burguillos García, Miguel Ángel, Venero Recio, José Luis, Kavanagh, E, Burguillos, MA, Kavanagh, Edel T., Joseph, Bertrand, Joseph, B,   +11 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Stage progression and neurological symptoms in Trypanosoma brucei rhodesiense sleeping sickness: role of the CNS inflammatory response [PDF]

, 2012
Background: Human African trypanosomiasis progresses from an early (hemolymphatic) stage, through CNS invasion to the late (meningoencephalitic) stage.
MacLean, L., Peter G. E. Kennedy (126080), MacLean Lorna, Sternberg, J.M., Sternberg, Jeremy M, Peter G E Kennedy, Hansotto Reiber (126078), Sternberg Jeremy M., Reiber, H., Kennedy Peter G. E., Jeremy M Sternberg, Kennedy, Peter G E, Lorna MacLean, MacLean, Lorna, Lorna MacLean (126077), Jeremy M. Sternberg (126082), Reiber Hansotto, Kennedy, P.G.E., Reiber, Hansotto, Hansotto Reiber   +19 more
core   +1 more source

Gut microbiota, circulating inflammatory proteins and sepsis: a bi-directional Mendelian randomization study

Frontiers in Cellular and Infection Microbiology
BackgroundGut microbiota is closely related to the occurrence and development of sepsis. However, the causal effects between the gut microbiota and sepsis, and whether circulating inflammatory proteins act as mediators, remain unclear.MethodsGut ...
Zuming Li, Liangcai Lin, Yunqi Kong, Jieni Feng, Xiaolei Ren, Yushi Wang, Xueru Chen, Siyi Wu, Rongyuan Yang, Rongyuan Yang, Jiqiang Li, Jiqiang Li, Jiqiang Li, Yuntao Liu, Yuntao Liu, Yuntao Liu, Yuntao Liu, Yue Lu, Yue Lu, Yue Lu, Yue Lu, Jiankun Chen, Jiankun Chen, Jiankun Chen   +23 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease [PDF]

, 2008
Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene
Jian Zhuang, Hongsui Wu, Shiliang Chen, Jian Su, Yuhui Zheng, Xiaoning Zhang, Jianguang Chen, Huanxin Yang, Zhihong Chen   +8 more
core   +1 more source