Results 111 to 120 of about 16,603 (230)

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, Volume 65, Issue 8, Page 963-976, August 2026.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang, Xin Fu, Jingchao Bai, Yanguo Liu, Kai Huang   +4 more
wiley   +1 more source

[Microbial model of Halobacterium salinarum for screening inhibitors of sterol biosynthesis].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2014
A highly effective and simple microbial test system for screening inhibitors of sterol biosynthesis (ISB) is described. The system is based on cultivation of the bacterial strain Halobacterium salinarum (former Halobacterium halobium), that possesses mevalonate pathway of sterol biosynthesis and is much similar in the biosynthesis to cholesterol ...
openaire   +2 more sources

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Macrophage signaling and function are regulated by distinct sterol biochemistries. [PDF]

J Lipid Res
Yaeger JDW, Pradhan B, Kerkvliet JG, Lawver AG, Sengupta S, Thiex NW, Francis KR.   +6 more
europepmc   +1 more source

Cirsium arvense–Derived ZnO Nanoparticles: Characterization, Mechanistic Modeling, Photocatalytic Degradation of Rhodamine B and Biomedical Applications

Nano Select, Volume 7, Issue 8, August 2026.
Green‐synthesized ZnO nanoparticles were fabricated using Cirsium arvense leaf extract and evaluated through physicochemical characterization, photocatalytic degradation, and biological applications. The nanoparticles exhibited efficient Rhodamine B removal (96%), recyclability, antioxidant activity, antibacterial effects, and selective cytotoxicity ...
Muhammad Usama Younas, Adil Usman, Ali Raza Kashif, Farasat Haider, Maryam Haider, Abdullah K. Alanazi, Basit Ali   +6 more
wiley   +1 more source

Sterol regulatory element‑binding proteins: Master regulators of lipid metabolic reprogramming in cancer and emerging therapeutic targets (Review). [PDF]

Oncol Rep
Liu Q, Wang R, Li Z, Liu Y, Wu L, Zhao Y, Yang J.   +6 more
europepmc   +1 more source

Sterol biosynthesis inhibitors

Biomedicine & Pharmacotherapy, 1989
openaire   +1 more source