Results 111 to 120 of about 17,106 (263)

Lamin B Receptor Regulates the Growth and Maturation of Myeloid Progenitors via its Sterol Reductase Domain: Implications for Cholesterol Biosynthesis in Regulating Myelopoiesis

, 2012
Lamin B receptor (LBR) is a bifunctional nuclear membrane protein with N-terminal lamin B and chromatin-binding domains plus a C-terminal sterol Δ14 reductase domain.
ROBERTI, Rita, Rahul Manmode, Peter Gaines, K. Malu, S. Fowler, M. Zwerger, Krishnakumar Malu, R. Manmode, Rita Roberti, Deepali Gotur, G. Subramanian, Monika Zwerger, Gayathri Subramanian, Samantha Fowler, D. Gotur, David Ryan, Pulkit Chaudhury, D. Ryan, P. Chaudhury, P. Gaines   +19 more
core   +1 more source

Antifungal Potential of Cumin Spice Seeds, Cuminum cyminum, Against Aspergillus fumigatus: Mechanistic Insights Into Ergosterol, Melanin, and Biofilm Inhibition

Food Frontiers, Volume 7, Issue 4, July 2026.
Antifungal effects and underlying mechanism of the action of the supercritical fluid extracted from the cumin (Cuminum cyminum) seeds and its volatile phyto‐constituents against pathogenic Aspergillus fumigatus. ABSTRACT Spices are aromatic culinary ingredients used worldwide for enhancing food flavors, folklore therapy, and their antiseptic ...
Acharya Balkrishna, Lovely Gupta, Rani Singh, Yash Varshney, Rishabh Dev, Pardeep Nain, Savita Lochab, Anurag Varshney   +7 more
wiley   +1 more source

RNA interference in crop protection: opportunities and challenges during the transition to commercialization

Pest Management Science, Volume 82, Issue 7, Page 5971-5986, July 2026.
RNA interference (RNAi) technologies, host‐induced gene silencing (HIGS) and spray‐induced gene silencing (SIGS), potentially offer sustainable crop protection. However, efficacy, costs, regulatory clarity, and socio‐environmental impacts require further evaluation for broader use.
Elisabetta Sergi, Anna Narduzzo, Alessandra Di Canito, Francesco Favaretto, Luca Nerva, Walter Chitarra, Lucia Bologna, Jacopo Bacenetti, Giuliana Maddalena, Simona Masiero, Ileana Vigentini, Gabriella De Lorenzis, Silvia Laura Toffolatti   +12 more
wiley   +1 more source

Co(II), Cu(II), and Ni(II) Coordination Complexes: Synthesis, Characterization, Experimental, and Computational Study on Potential Antiplasmodial Activity

ChemMedChem, Volume 21, Issue 12, 26 June 2026.
Four isostructural complexes (C1–C4) derived from 2‐(tert‐butoxy)‐6‐(1H‐imidazol‐1‐yl)pyridine with axial halides exhibit octahedral trans M(L)4X2 geometries, confirmed by X‐ray diffraction. They feature a discrete 1,6M7−1 topology, identified using ToposPro analysis.
David Ezenarro‐Salcedo, Daniela Fonseca‐López, Alexander Patiño‐Cubides, María C. Velasco‐Pareja, María F. Yasnot‐Acosta, Camilo Serrano‐Sterling, Ana Rodríguez, Mario A. Macías, Adrian L. Orjuela, Augusto Valderrama‐Aguirre, John J. Hurtado   +10 more
wiley   +1 more source

[Microbial test-system for screening of inhibitors of sterol biosynthesis].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2014
New effective economic microbial test-system for screening of microbial metabolites, that are inhibitors of sterol biosynthesis, is proposed. It is based on cultivation of fungal strain Acremonium fusidioides (former Fusidium coccineum), that produces fusidic acid (fusidin) that is antibiotic of steroid structure.
openaire   +2 more sources

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

The Neurospora crassa erg3 gene encodes a protein with sequence homology to both yeast sterol C-14 reductase and chicken lamin B receptor

, 1994
The erg3 gene ofNeurospora crassa was sequenced (EMBL accession no. X77955) and found to encode a protein of 490 amino acid residues with significant homology to the yeast sterol biosynthetic enzyme C-14 reductase (39% identity) and also to the C ...
Kasbekar, D. P., Papavinasasundaram, K. G.   +1 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Synthesis and testing of sterol biosynthesis inhibitors with Candida albicans

, 2002
A series of lanosterol analogs which contain a heteroatom substituted for C-24 or C-25 or otherwise modified in the double bond character in the sterol side chain at C-24 (25) have been prepared and assayed with Candida albicans as antifungal agents. 25-
Liu, Jialin
core  

Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.

, 2003
This paper describes the synthesis of some novel azasterols based on (20R,22xi)-5alpha-pregnan-20-(piperidin-2-yl)-3beta,20-diol. These compounds are potential inhibitors of the enzyme sterol 24-methyltransferase (24-SMT), which is a vital enzyme in the ...
Croft, Simon L, Gilbert, Ian H, Rodrigues, Juliany CF, Braga, Marina Vianna, Urbina, Julio, Gonzalez Pacanowska, Dolores, Magaraci, Filippo, Ruiz-Perez, Luis M, Rodrigues, Juliany C. F., Pacanowska, Dolores Gonzalez, de Luca-Fradley, Kate, Jimenez, Carmen Jimenez, Gilbert, Ian H., de Souza, Wanderley, Yardley, Vanessa, Rodrigues, Carlos, Jimenez, Carmen, Croft, Simon L., Ruiz-Perez, Luis M.   +18 more
core   +1 more source