Results 121 to 130 of about 17,106 (263)

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Calpain-4 Knockdown Modulates Cholesterol Metabolism and LXRα Nuclear Localization in Experimental Alcohol-Related Liver Disease. [PDF]

Alcohol Clin Exp Res (Hoboken)
Calpain‐4 knockdown in alcohol‐related liver disease promotes LXRα nuclear translocation and HMGCR cleavage, enhancing cholesterol efflux via upregulation of ABCA1/ABCG1 and CPT‐1. This mechanism reduces hepatic cholesterol accumulation and microvesicular steatosis without affecting triglycerides or inflammatory markers, identifying calpain‐4 as a ...
Kitano N, Li J, Taborski S, Vanderpuye CM, Muddasani P, Chaudhary S, Liu JJ, Liu S, Beier JI, Argemi J, Bataller R, Arteel GE.   +11 more
europepmc   +2 more sources

Status Epilepticus Alters the Function of Brain-Derived Extracellular Vesicles. [PDF]

J Extracell Vesicles
ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Reed SL, Wang Y, Li Y, Hu G, Yang J, Yao B, Escayg A.   +6 more
europepmc   +2 more sources

Species Dependent Toxicity Comparison Outcome

Advanced Science, Volume 13, Issue 34, 19 June 2026.
By quantitatively assessing and comparing toxicity responses across different animal species and material compositions, our data reveal that toxicity rankings among different materials may be reversed across species. ABSTRACT Toxicity comparison plays a crucial role in material selection across diverse application fields.
Lian Xiao, Zhan Yu, Sihang Liu, Yuheng Liu, Chong Deng, Yugang Zhao, Yi Huang, Zhi‐Gang Zheng   +7 more
wiley   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, Volume 13, Issue 33, 15 June 2026.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells

, 2017
Sterol intermediates of the cholesterol biosynthetic pathway have drawn attention for novel biological activities. Follicular fluid meiosis activating sterol (FF-MAS) is a LXRα ligand and a potential modulator of physiologic processes regulated by ...
Lara Macchioni, GIOIELLO, ANTIMO, SEBASTIANI, Bartolomeo, Paolo Scarpelli, Bartolomeo Sebastiani, Bruno Cerra, Leonardo Gatticchi, Antimo Gioiello, CERRA, BRUNO, Rita Roberti, SCARPELLI, PAOLO, MACCHIONI, Lara, Gatticchi, Leonardo, Rita, Roberti   +13 more
core   +1 more source

Transcriptomic Analysis in the Liver of Two Rabbit Lines Divergently Selected for Intramuscular Fat Content

Animal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The intramuscular fat (IMF) content is an important indicator of meat quality, affecting the sensory properties of meat. IMF is a complex trait with polygenic nature. This research aimed to identify differentially expressed (DE) genes and key transcription factors (TFs) associated with IMF deposition in the liver of two rabbit lines ...
Jesús Valdés‐Hernández, Agostina Zubiri‐Gaitán, Marina Martínez‐Álvaro, Agustín Blasco, Pilar Hernández   +4 more
wiley   +1 more source

X-ray Structure of 4,4′-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14α-Demethylase (CYP51)

, 2008
A universal step in the biosynthesis of membrane sterols and steroid hormones is the oxidative removal of the 14α-methyl group from sterol precursors by sterol 14α-demethylase (CYP51).
Eddine, Ali Nasser, Warrier, Thulasi, Kaufmann, Stefan H. E., Podust, Larissa M., von Kries, Jens P., Podust, Mikhail V.   +5 more
core   +1 more source

HDL‐mimetic peptide treatment reverses APOE4‐induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Allison Chang, Minwoo Kim, Matthew Glittenberg, Wenhui Qu, Danni Li, Ling Li   +5 more
wiley   +1 more source

Effect of sterol biosynthesis inhibitors and azole-type inducers on growth and development of Plasmopara viticola on grapevine

, 2015
The effect of various azole fungicides (demethylation inhibitors, DMIs), mainly triazoles, that interfere with sterol metabolism in higher fungi, triazole-type inducers and an inhibitor of plant brassinosteroid biosynthesis on growth and spore production
Martínez-Prada, I., Kortekamp, A.
core   +1 more source