Results 131 to 140 of about 17,106 (263)

Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir, Astrid Kaiser, Felix F. Lillich, Pascal Heitel   +3 more
wiley   +1 more source

Fungicidal Activity and In Silico Studies of Triazoles Derived From Glycerol Against Neocosmospora falciformis, A Causal Agent of Guava Tree Decline

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Among seventeen 1,2,3‐triazoles synthetized from glycerol (4a–4q), compound 4l completely inhibited mycelial growth and eliminated N. falciformis spores at 1,000 µg/mL, exhibiting enhanced antifungalactivity and strong binding within the FsCYP51 active site, which highlights its promise as a lead candidate for antifungal development in both biological ...
Adilson Vidal Costa, Arêssa de Oliveira Correia, Breno Benvindo dos Anjos, Mariana Belizario de Oliveira, Poliana Aparecida Rodrigues Gazolla, Vagner Tebaldi de Queiroz, Juliana Alves Resende, Róbson Ricardo Teixeira, Osmair Vital de Oliveira, Gabriel Jacomin Vargas, Waldir Cintra de Jesus Júnior, Willian Bucker Moraes, Fábio Ramos Alves   +12 more
wiley   +1 more source

Bioinspired Aerobic Oxidation to Functionalize the CD Ring of the Steroid Framework: Synthesis and Stereochemical Assignments of Gargalol C and Related Oxysterols

ChemistryEurope, Volume 4, Issue 6, June 2026.
Bioinspired aerobic oxidation of the CD ring part of 5,6‐α‐epoxysterols was achieved by two means. The study not only led to the first syntheses and configurational (re)assignments of naturally occurring bioactive C14‐ or C15‐hydroxysterols but also gives valuable insights into the biosynthetic pathways of advanced oxysterols. A series of NMR and X‐ray
Hinata Togo, Yui Kanda, Shoji Kobayashi
wiley   +1 more source

CYP46A1‐Targeted Treatment Alleviates Long‐Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Lin Li, You Shi, Qing Luo, Peiwen Guo, Taotao Jin, Xufang Ru, Zhouyang Jiang, Yin Niu, Wenyan Li, Yujie Chen, Zhi Chen   +10 more
wiley   +1 more source

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Harnessing Fatty Acid By‐Products for Diabetes Management: Insights From Nutritional and Biological Research

eFood, Volume 7, Issue 3, June 2026.
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy, Abdelaali Balahbib, Meriem El Fessikh, Saïd Gharby, Nasreddine El Omari, Waleed Al Abdulmonem, Gokhan Zengin, Abdelhakim Bouyahya   +7 more
wiley   +1 more source

A Comprehensive Review on Nutrition, Phytochemistry, Pharmacology and Food Application Perspectives of Bioactive Rich Superfruits

Future Postharvest and Food, Volume 3, Issue 2, Page 163-184, June 2026.
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja, Javid Iqbal Mir, Mahendra Kumar Verma, Aamir Hussain Dar   +3 more
wiley   +1 more source

Steroidal allenes as inhibitors of sterol biosynthesis

Steroidal allenes as inhibitors of sterol biosynthesis
identifier:oai:t2r2.star.titech.ac.jp ...
openaire  

Green Biosynthesis of Bioactive Streptomyces Metabolites Using Edible Mushrooms: Implications for Glycemic Control and Hepatic Protection in Diabetic Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Mushroom‐mediated Streptomyces metabolites improved fasting blood glucose, reduced hepatic injury markers, restored antioxidant defenses, and showed supportive molecular docking interactions, indicating potential as a functional food or nutraceutical for diabetes‐associated metabolic and liver protection.
Yahye Ahmed Nageye, Abdirasak Sharif Ali, Kizito Eneye Bello   +2 more
wiley   +1 more source

[Microbial model of Halobacterium salinarum for screening inhibitors of sterol biosynthesis].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 2014
A highly effective and simple microbial test system for screening inhibitors of sterol biosynthesis (ISB) is described. The system is based on cultivation of the bacterial strain Halobacterium salinarum (former Halobacterium halobium), that possesses mevalonate pathway of sterol biosynthesis and is much similar in the biosynthesis to cholesterol ...
openaire   +2 more sources