Results 151 to 160 of about 32,395 (260)

Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Epithelial cells (ECs) of the female genital tract (FGT) serve as an essential barrier and the first line of defense against sexually transmitted pathogens. Beyond providing a physical barrier, these cells actively contribute to immune responses through pathogen recognition, cytokine release, and modulation of adaptive immune responses ...
Lauren Jirik, Shreya Joshi, Aisha Nazli, Charu Kaushic   +3 more
wiley   +1 more source

Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness

Genes to Cells, Volume 31, Issue 3, May 2026.
COP1 promotes HCC lipid metabolism and stemness via the functional interaction with AKR1D1 and TMEM65 genes, respectively, indicating its potential as a therapeutic target for treating primary HCC and preventing metastasis and/or recurrence. ABSTRACT We have previously defined the constitutive photomorphogenic protein 1 (COP1) gene as a therapeutic ...
Eun‐Hye Jeon, An‐Na Bae, Hajin Lee, Keon Uk Park, Hyun Mu Shin, Jong Ho Park, Kwang Seok Kim, In‐Chul Park, Yun‐Han Lee   +8 more
wiley   +1 more source

Genetic Differentiation in the SdhC Subunit Confers Intrinsic Resistance to SDHI Fungicides in Fusarium asiaticum

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
In Fusarium asiaticum, two homologous SdhC subunits (FaSdhC1/C2) regulate sensitivity to SDHI fungicides: deletion of FaSDHC1 decreases sensitivity, while deletion of FaSDHC2 increases it. Multiple mutations in ΔFaSDHC2 confer resistance to SDHI fungicides.
Jichang Song, Jiakai Wang, Xudong Liu, Yinkai Liu, Lianyu Bi, Meixia Li, Yiqiang Cai, Mingguo Zhou, Yabing Duan   +8 more
wiley   +1 more source

The potential of metabolic engineering for sustainable phytosterol production. [PDF]

Adv Biotechnol (Singap)
Hu R, Di X, Li G, Schaller H, Hemmerlin A, Liao P.   +5 more
europepmc   +1 more source

Environmental Circulation of Aspergillus fumigatus With Reduced Susceptibility to Agricultural Triazole in Brazil: Clonal Dissemination of Potentially Resistant Genotypes

Mycoses, Volume 69, Issue 5, May 2026.
ABSTRACT Background Aspergillus fumigatus resistance to triazole antifungals poses an increasing global health concern. Moreover, the cross‐resistance between azole antifungal agents used in clinical settings and those applied in agriculture has become an important emerging issue.
Dality Keffelen de Barros Rodrigues, Manuel Leeuwerik, Balázs Brankovics, Wellington Santos Fava, James Venturini, Wieland Meyer, Teppei Arai, Hidetaka Majima, Akira Watanabe, Marcia de Souza Carvalho Melhem   +9 more
wiley   +1 more source

Integrated Genomic and Phenotypic Analyses Reveal Convergent Resistance Patterns in Clinical Candida tropicalis Isolates

Mycoses, Volume 69, Issue 5, May 2026.
ABSTRACT Background The incidence of Candida tropicalis isolation is increasing in hospital settings. High azole resistance and mortality rates make it a pathogen that requires further analysis. Methods Fourteen azole resistant Candida glabrata clinical isolates were collected from a Lebanese hospital and analysed through whole genome sequencing for ...
Christy Chedraoui, Nour Fattouh, Setrida El Hachem, Tsolaire Sourenian, Louna El Bitar, Lama El Moheb, Anna‐Souraya Sleiman, Ibrahim Bitar, Rola Husni, Roy A. Khalaf   +9 more
wiley   +1 more source

Targeting cholesterol-driven immunometabolism in cancer: from molecular circuits to clinical translation. [PDF]

Mol Cancer
Ma Q, Chen B, Li T, Lu Y, Li X.
europepmc   +1 more source

LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice [PDF]

, 2018
Jeong, Lak Shin, Jeong, Se-Jin, Kim, Gyudong, Oh, Goo Taeg, Park, Jong-Gil, Yu, Jinha   +5 more
core   +1 more source

A Novel Dual‐Target Compound Designed With Potent Herbicidal and Fungicidal Activity Inspired by Conserved Phytoene Synthase Domains

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2903-2913, May 2026.
ABSTRACT The development of dual‐target inhibitors represents a cost‐effective strategy for integrated pest management. Here, we report the first dual‐target inhibitors designed against the evolutionarily conserved domain of phytoene synthase (PSY), a key enzyme in carotenoid biosynthesis.
Di Zhang, Liang Li, Chunxue Wang, Nuo Zhou, Zhilei Yu, Tianyi Shen, Baifan Wang, Qiang Bian, Dejun Ma, Yucheng Gu, Han Xu, Zhen Xi   +11 more
wiley   +1 more source

Antifungal efficacy of linoleic-acid-rich Cucurbita pepo L. seed oil revealed by GC-MS profiling of lipids and bioactive markers, ergosterol depletion, and network pharmacology. [PDF]

BMC Microbiol
Mohamed ET.
europepmc   +1 more source