Results 181 to 190 of about 105,210 (313)

Synaptic Pathology in Traumatic Brain Injury and Therapeutic Insights. [PDF]

Int J Mol Sci
Nuthalapati P, Holmes SE, Altalib HH, Fesharaki-Zadeh A.   +3 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Lithium restores inhibitory function and neuronal excitability through GSK-3β inhibition in a bipolar disorder-associated Ank3 variant mouse model. [PDF]

Neuropharmacology
Caballero-Florán RN, Dean KP, Nelson AD, Min L, Jenkins PM.   +4 more
europepmc   +1 more source

5-HT_1A, SST₁, and SST₂receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum

, 2009
Jaime Pei Pei Foong, Laura J. Parry, Rachel M. Gwynne, Joel C. Bornstein   +3 more
openalex   +2 more sources

TREM2 Downregulation Disrupts Microglial Function and Synaptic Pruning Through RA/RARα Signaling: Mechanisms Underlying Autism‐Like Behaviors

Pediatric Discovery, EarlyView.
Downregulation of TREM2 induces autism‐like behaviors in healthy rats by impairing microglial function and triggering aberrant synaptic pruning. RA/RARα signaling pathway modulates alterations in TREM2 expression. Serum sTREM2 levels correspond to alterations in brain TREM2 expression.
Min Lu, Kexin Bai, Yali Bai, Yuan Miao, Tingjiao Zhao, Yi Yang, Jie Chen, Ting Yang, Tingyu Li, Hua Wei   +9 more
wiley   +1 more source

Disorganized hippocampal excitatory and inhibitory connectivity in a mouse model of Alzheimer's disease. [PDF]

IBRO Neurosci Rep
Ito T, Ono M, Yamaki S, Hori Y, Muramoto S, Yamamoto R, Furuyama T, Kato N.   +7 more
europepmc   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Recurrent circuits encode de novo visual center-surround computations in the mouse superior colliculus. [PDF]

PLoS Biol
Cui P, Song K, Mariatos-Metaxas D, Isla AG, Femenia T, Lazaridis I, Meletis K, Kumar A, Kardamakis AA.   +8 more
europepmc   +1 more source

Ionic mechanisms of the slow inhibitory postsynaptic potential of sympathetic ganglion cells in bullfrogs.

, 1976
Takashi Akasu, K. Koketsu
openalex   +2 more sources

MXene‐Based Flexible Memory and Neuromorphic Devices

Small, EarlyView.
The unique two‐dimensional structure, excellent electrical conductivity, and diverse surface groups of MXenes have garnered significant attention. Coupled with their exceptional flexibility, MXene‐based devices hold immense potential for flexible memory and neuromorphic systems. This review comprehensively discusses the fundamentals of flexible devices,
Yan Li, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Yan Yan, Shuangmei Xue, Kui Zhou, Meng Zhang, Yutong Zhang, Qi‐Jun Sun, Yi Liu, Vellaisamy A. L. Roy, Ye Zhou, Su‐Ting Han   +13 more
wiley   +1 more source