Results 181 to 190 of about 92,954 (316)

Interactions of Therapeutic Antibodies With Presynaptically‐Released Misfolded Proteins in Neurodegenerative Diseases. A Spatial Monte‐Carlo Simulation Study

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The spatial progression hypothesis of misfolded tau and alpha‐synuclein proteins in Alzheimer's and Parkinson's Disease proposes the release of proteins from a presynaptic membrane followed by diffusion over the synaptic cleft and uptake by the postsynaptic membrane in the afferent neuron.
Jamie Goff, Maryam Khalifa, Shaina M. Short, Piet H. van der Graaf, Hugo Geerts   +4 more
wiley   +1 more source

Hierarchical competing inhibition circuits govern motor stability in C. elegans. [PDF]

Nat Commun
Zhang Y, Shi Y, Zeng K, Chen L, Gao S.
europepmc   +1 more source

Serotonin‐mediated inhibitory postsynaptic potential in guinea‐pig prepositus hypoglossi and feedback inhibition by serotonin.

, 1990
Daniel H. Bobker, JT Williams
openalex   +1 more source

Update on Gene Therapy in the Treatment of Hereditary Hearing Loss

Sensory Neuroscience, EarlyView.
Gene therapy is a promising therapeutic approach for genetic disorders, including three major gene therapy strategies: gene replacement, gene suppression, and gene editing. After transmitting genes to the inner ear through appropriate pathways, repair the cochlea in order to achieve the goal of treating hereditary hearing loss.
Weiwei He, Shanying Han, Xinghong Liu, Xiaotong Huang, Wen Yang, Xinghua Tang, Chuan Dong, Jiangang Fan   +7 more
wiley   +1 more source

Altered synaptic homeostasis: a key factor in the pathophysiology of depression. [PDF]

Cell Biosci
Wang B, He T, Qiu G, Li C, Xue S, Zheng Y, Wang T, Xia Y, Yao L, Yan J, Chen Y.   +10 more
europepmc   +1 more source

MXene‐Based Flexible Memory and Neuromorphic Devices

Small, EarlyView.
The unique two‐dimensional structure, excellent electrical conductivity, and diverse surface groups of MXenes have garnered significant attention. Coupled with their exceptional flexibility, MXene‐based devices hold immense potential for flexible memory and neuromorphic systems. This review comprehensively discusses the fundamentals of flexible devices,
Yan Li, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Yan Yan, Shuangmei Xue, Kui Zhou, Meng Zhang, Yutong Zhang, Qi‐Jun Sun, Yi Liu, Vellaisamy A. L. Roy, Ye Zhou, Su‐Ting Han   +13 more
wiley   +1 more source

A novel method for reliably measuring miniature and spontaneous postsynaptic events in whole-cell patch clamp recordings in the central nervous system. [PDF]

Front Cell Neurosci
Dervinis M, Major G.
europepmc   +1 more source

5-HT_1A, SST₁, and SST₂receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum

, 2009
Jaime Pei Pei Foong, Laura J. Parry, Rachel M. Gwynne, Joel C. Bornstein   +3 more
openalex   +2 more sources

Sevoflurane induces the inattention, cognitive impairment, and motor dysfunction by hypermethylation of retinoic acid receptor α in the medial prefrontal cortex of neonatal mice

VIEW, EarlyView.
The mechanisms underlying neurodevelopmental toxicity induced by repeated exposure to general anesthesia in neonatal mice remain to be fully elucidated. In this study, neonatal mice were exposed to sevoflurane on postnatal days 6, 8, and 10. On postnatal day 30, the medial prefrontal cortex was collected for whole‐genome bisulfite sequencing and RNA ...
Yu Hou, Shuai Li, Qi Hou, Runjia Wang, Zhenghao Deng, Xiyuan Xu, Zhichao Li, Linhui Ma, Yuan Shen, Qidong Liu, Hui Zheng   +10 more
wiley   +1 more source

Behavioral resilience via dynamic circuit firing homeostasis. [PDF]

Proc Natl Acad Sci U S A
Hoagland A, Schultz R, Cai Z, Newman ZL, Isacoff EY.   +4 more
europepmc   +1 more source