Results 211 to 220 of about 105,210 (313)

The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer's disease and translational opportunities. [PDF]

Transl Neurodegener
Song Y, Ni J, Qing H, Quan Z.
europepmc   +1 more source

Muscle Regeneration Can Be Rescued in a Telomerase Deficient Zebrafish Model of Ageing by MMP Inhibition

Aging Cell, EarlyView.
Inhibition of MMP9/13 restores both muSC behaviour and regeneration, while macrophage ablation enhances muSC recruitment to the injury, but fails to improve muscle repair in telomerase‐deficient zebrafish larvae. ABSTRACT Ageing progressively impairs skeletal muscle regeneration, contributing to reduced mobility and quality of life. While the molecular
Yue Yuan, Carlene Dyer, Robert D. Knight
wiley   +1 more source

Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities. [PDF]

Nat Commun
Macha A, Liebsch F, Bruckisch EHW, Burdina N, von Stülpnagel I, Benting K, Gunkel M, Behrmann E, Schwarz G.   +8 more
europepmc   +1 more source

Translational Remodeling of the Synaptic Proteome During Aging

Aging Cell, EarlyView.
Aging induces a decoupling of protein regulation between the soma and the synapse. In particular, transcripts coding for ribosomal proteins decrease and their corresponding proteins increase in the synapse while the opposite happens in the soma. At the same time, synapse‐specific regulation of splicing takes place.
Cinzia Caterino, Martino Ugolini, William Durso, Kristina Jevdokimenko, Marco Groth, Konstantin Riege, Matthias Görlach, Eugenio Fornasiero, Alessandro Ori, Steve Hoffmann, Alessandro Cellerino   +10 more
wiley   +1 more source

Single-nucleus RNA sequencing: immature excitatory neurons and transformed glia build human BRAF^V600E-negative gangliogliomas. [PDF]

Brain Commun
Cases-Cunillera S, Müller P, van Waardenberg AJ, Schoch S, Huberfeld G, Höllig A, Delev D, Hamed M, Becker AJ, van Loo KMJ.   +9 more
europepmc   +1 more source

Potential TMS biomarkers for GABAB receptor engagement in alcohol use disorder: A systematic review of existing evidence

Alcohol, Clinical and Experimental Research, EarlyView.
This systematic review emphasizes the critical role of GABAB receptors (GABABR) in alcohol use disorder (AUD). While GABABR agonists enhance cortical inhibition, as measured by transcranial magnetic stimulation (TMS)‐based markers, alcohol consumption alters GABABR ‐dependent neurophysiological measures, suggesting GABABR dysfunction plays a key role ...
Chiara Montemitro, Sara Terrezza, Federico Maruottolo, Andrea Costumati, Markus Heilig   +4 more
wiley   +1 more source

Spike Timing-Dependent Plasticity and Random Inputs Shape Interspike Interval Regularity of Model STN Neurons. [PDF]

Biomedicines
Thieu T, Melnik R.
europepmc   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Presynaptic maturation of inhibitory connections onto vasoactive intestinal polypeptide-expressing GABAergic interneurons in the mouse barrel field. [PDF]

Pflugers Arch
Simacek CA, Kirischuk S, Mittmann T.
europepmc   +1 more source

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source