Results 211 to 220 of about 276,610 (317)

Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Pharmacological MRI (pharmaMRI) has emerged as a powerful tool to study how psychoactive drugs affect brain function and to uncover mechanisms of drug action in psychiatric disorders. This review provides an overview of key techniques used in pharmaMRI, including BOLD‐fMRI, arterial spin labeling (ASL), and cerebral blood volume (CBV) mapping,
Christin Y. Sander, Tudor M. Ionescu, Mitul A. Mehta, Ottavia Dipasquale, Anouk Schrantee   +4 more
wiley   +1 more source

Pre- and Post-synaptic Mechanisms of Neuronal Inhibition Assessed Through Biochemically Detailed Modeling of GABA_B Receptor Signaling. [PDF]

J Neurosci
Mäki-Marttunen T, Kismul JF, Pajo K, Schulz JM, Manninen T, Einevoll GT, Linne ML, Andreassen OA, Kotaleski JH.   +8 more
europepmc   +1 more source

Vestibular Evoked Myogenic Potentials to Diagnose Vestibular Neuritis: A Scoping Review

The Laryngoscope, EarlyView.
Standardization of stimulation and recording protocols is essential to improve comparability across VEMP studies. Integrating cervical and ocular VEMPs with other vestibular tests enhances diagnostic accuracy and supports precise localization of vestibular neuritis.
Diego Piatti, Laura Casagrande Conti, Gianluca Paolocci, Iole Indovina, Marco Tramontano, Leonardo Manzari   +5 more
wiley   +1 more source

Deficiency of Kif15 impairing synaptic development leads to mood disorder in mice. [PDF]

PLoS Genet
He X, Zhang W, Chen X, Dong Z, Wei C, Wu T, Kong D, Kong R, Wu R, Liu Y, Liu M.   +10 more
europepmc   +1 more source

P4‐ATPases as Phospholipid Flippases: From Membrane Dynamics to Human Disorders

Medicine Bulletin, EarlyView.
ABSTRACT P4‐ATPases (P4 subfamily of P‐type ATPases) flippase complex includes an α‐subunit responsible for catalysis and a supporting β‐subunit, which consumes energy by catalyzing the hydrolysis of ATP, thereby facilitating the translocation of aminophospholipids from the outer to the inner leaflet of cellular membranes to maintain the asymmetric ...
Guangyi Chen, Yeming Yang, Xianjun Zhu
wiley   +1 more source

Extracellular Matrix (ECM)-Regulated Molecular Switches: Tissue Inhibitors of Metalloproteinases in Synaptic Formation and Neuropathic Diseases. [PDF]

Cell Mol Neurobiol
Qi S, Wang S, Tan Y, Pan C, Bi X.
europepmc   +1 more source

Investigation of the Determinants of Disease Severity in Patients with Idiopathic Normal Pressure Hydrocephalus

Movement Disorders Clinical Practice, EarlyView.
Background The determinants of the severity of idiopathic normal pressure hydrocephalus (iNPH) have not been examined previously. Objective To reveal the clinical determinants of the clinical severity of iNPH in detail. To provide some clinical remarks and contributions to the understanding of the pathophysiology.
Halil Onder, Ahmet Gunaydin, Nursu Erdogan, Selcuk Comoglu   +3 more
wiley   +1 more source

GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus. [PDF]

Front Cell Neurosci
Netsyk O, Korol SV, Birnir B, Jin Z.
europepmc   +1 more source

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti‐Related Peptide (NPY/AgRP) Neurons

Obesity, EarlyView.
ABSTRACT Objective Topiramate is a medication used off‐label, or in combination with phentermine, for the management of obesity. However, its mechanism of action remains elusive. As many obesity medications target the brain, we aimed to determine if topiramate influences the activity of hypothalamic melanocortin neurons known to regulate energy balance.
Moein Minbashi Moeini, Olivier Lavoie, Alexandre Caron, Kevin W. Williams, Natalie J. Michael   +4 more
wiley   +1 more source

Optogenetic Approach for Investigating Descending Control of Nociception in Ex Vivo Spinal Cord Preparation. [PDF]

Bio Protoc
Krotov V, Blashchak I, Moore J, Moore A, Romanenko S, Voitenko N, Belan P.   +6 more
europepmc   +1 more source