Results 21 to 30 of about 92,954 (316)

Efavirenz restored NMDA receptor dysfunction and inhibited epileptic seizures in GluN2A/Grin2a mutant mice

Frontiers in Neuroscience, 2023
IntroductionN-methyl-D-aspartate receptor (NMDAR) is one of the main receptor of the excitatory neurotransmitter glutamate in the brain, which is the key determinant of the excitatory/inhibitory balance of neural network.
Teng Zhao, Rui Zhong, Xinyue Zhang, Guangjian Li, Chunkui Zhou, Shaokuan Fang, Ying Ding, Weihong Lin   +7 more
doaj   +1 more source

Inhibitory postsynaptic actions of taurine, GABA and other amino acids on motoneurons of the isolated frog spinal cord [PDF]

, 1975
The actions of glycine, GABA, α-alanine, β-alanine and taurine were studied by intracellular recordings from lumbar motoneurons of the isolated spinal cord of the frog.
Altmann, Aprison, Barker, Barron, Biscoe, Brookhart, Bruggencate, Bruggencate, Bruggencate, Collins, Curtis, Curtis, Curtis, Curtis, Curtis, Curtis, Davidoff, Davidoff, Davidoff, Davidoff, Diamond, Eccles, Eccles, Ecker, Engberg, Fadiga, Fukuya, Groat, Haas, Hill, Hösli, Hösli, J. Krumnikl, Johnston, Katz, Kellerth, Kubota, Kuno, Larson, Lucia Schindler, M. Linder, Nicoll, Obata, P. Grafe, Roper, Schmidt, Sonnhof, Sonnhof, Tebecis, Tebecis, U. Sonnhof, Werman, Werman   +52 more
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Modeling Calcium Dynamics and Inhibition Based Synaptic Plasticity in Dendritic Spines

Mathematical Modelling and Analysis, 2014
Inhibitory synapses through GABAergic channels not only change spine's calcium dynamics but also modulate postsynaptic current mediated through glutamate receptors.
Muhammad Dur-e-Ahmad
doaj   +1 more source

Effects of guanidine on synaptic transmission in the spinal cord of the frog [PDF]

, 1977
The effects of guanidine on motoneurons of the isolated frog spinal cord were studied by adding the drug to the solution bathing the cord during intracellular recording. Guanidine (5·10–4 M) did not alter the membrane potential of motoneurons.
A. K�hner, B. Katz, E. Gergens, E. H. Lambert, F. Colomo, F. H. Norris, H. Ter�v�inen, J. I. Simpson, K. Koizumi, K. Ricker, M. A. Kamenskaya, M. A. Kamenskaya, M. Otsuka, P. Grafe, R. C. Scaer, S. D. Erulkar, S. J. Oh, U. Sonnhof, U. Sonnhof, W. C. Wiederholt   +19 more
core   +1 more source

Spike-timing dependent plasticity in inhibitory circuits

Frontiers in Synaptic Neuroscience, 2010
Inhibitory circuits in the brain rely on GABA-releasing interneurons. For long, inhibitory circuits were considered weakly plastic in the face of patterns of neuronal activity that trigger long-term changes in the synapses between excitatory principal ...
Karri P Lamsa, Dimitri M. Kullmann, Melanie A Woodin   +2 more
doaj   +1 more source

Phenomenological incorporation of nonlinear dendritic integration using integrate-and-fire neuronal frameworks. [PDF]

PLoS ONE, 2013
It has been discovered recently in experiments that the dendritic integration of excitatory glutamatergic inputs and inhibitory GABAergic inputs in hippocampus CA1 pyramidal neurons obeys a simple arithmetic rule as V(S)(Exp) ≈ V(E)(Exp) + V(I)(Exp) + kV(
Douglas Zhou, Songting Li, Xiao-hui Zhang, David Cai   +3 more
doaj   +1 more source

Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices [PDF]

, 1979
Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated.
Galvan, Martin, Grafe, Peter, Ten Bruggencate, Gerrit   +2 more
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Nitric oxide signalling modulates synaptic inhibition in the superior paraolivary nucleus (SPN) via cGMP-dependent suppression of KCC2

Frontiers in Neural Circuits, 2014
Glycinergic inhibition plays a central role in the auditory brainstem circuitries involved in sound localization and in the encoding of temporal action potential firing patterns.
Lina eYassin, Susanne eRadtke-Schuller, Hila eAsraf, Benedikt eGrothe, Michal eHershfinkel, Ian D Forsythe, Conny eKopp-Scheinpflug   +6 more
doaj   +1 more source

Regulation of Irregular Neuronal Firing by Autaptic Transmission [PDF]

, 2016
The importance of self-feedback autaptic transmission in modulating spike-time irregularity is still poorly understood. By using a biophysical model that incorporates autaptic coupling, we here show that self-innervation of neurons participates in the ...
Chen, Mingming, Cui, Yan, Guo, Daqing, Ma, Jingling, Perc, Matjaz, Wu, Shengdun, Xia, Yang, Xu, Peng, Yao, Dezhong, Zhang, Yangsong   +9 more
core   +3 more sources

Imbalance of Excitation and Inhibition at Threshold Level In the Auditory Cortex

Frontiers in Neural Circuits, 2015
The interplay of cortical excitation and inhibition is a fundamental feature of cortical information processing. Excitation and inhibition in single cortical neurons are balanced in their response to optimal sensory stimulation due to thalamocortical ...
Yan eZhao, Yan eZhao, Zizhen eZhang, Xiuping eLiu, Colin eXiong, Zhongju eXiao, Jun eYan   +6 more
doaj   +1 more source