Results 31 to 40 of about 258,461 (334)

Effects of guanidine on synaptic transmission in the spinal cord of the frog [PDF]

, 1977
The effects of guanidine on motoneurons of the isolated frog spinal cord were studied by adding the drug to the solution bathing the cord during intracellular recording. Guanidine (5·10–4 M) did not alter the membrane potential of motoneurons.
A. K�hner, B. Katz, E. Gergens, E. H. Lambert, F. Colomo, F. H. Norris, H. Ter�v�inen, J. I. Simpson, K. Koizumi, K. Ricker, M. A. Kamenskaya, M. A. Kamenskaya, M. Otsuka, P. Grafe, R. C. Scaer, S. D. Erulkar, S. J. Oh, U. Sonnhof, U. Sonnhof, W. C. Wiederholt   +19 more
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Modeling Calcium Dynamics and Inhibition Based Synaptic Plasticity in Dendritic Spines

Mathematical Modelling and Analysis, 2014
Inhibitory synapses through GABAergic channels not only change spine's calcium dynamics but also modulate postsynaptic current mediated through glutamate receptors.
Muhammad Dur-e-Ahmad
doaj   +1 more source

Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices [PDF]

, 1979
Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated.
Galvan, Martin, Grafe, Peter, Ten Bruggencate, Gerrit   +2 more
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Spike-timing dependent plasticity in inhibitory circuits

Frontiers in Synaptic Neuroscience, 2010
Inhibitory circuits in the brain rely on GABA-releasing interneurons. For long, inhibitory circuits were considered weakly plastic in the face of patterns of neuronal activity that trigger long-term changes in the synapses between excitatory principal ...
Karri P Lamsa, Dimitri M. Kullmann, Melanie A Woodin   +2 more
doaj   +1 more source

Nitric oxide signalling modulates synaptic inhibition in the superior paraolivary nucleus (SPN) via cGMP-dependent suppression of KCC2

Frontiers in Neural Circuits, 2014
Glycinergic inhibition plays a central role in the auditory brainstem circuitries involved in sound localization and in the encoding of temporal action potential firing patterns.
Lina eYassin, Susanne eRadtke-Schuller, Hila eAsraf, Benedikt eGrothe, Michal eHershfinkel, Ian D Forsythe, Conny eKopp-Scheinpflug   +6 more
doaj   +1 more source

Imbalance of Excitation and Inhibition at Threshold Level In the Auditory Cortex

Frontiers in Neural Circuits, 2015
The interplay of cortical excitation and inhibition is a fundamental feature of cortical information processing. Excitation and inhibition in single cortical neurons are balanced in their response to optimal sensory stimulation due to thalamocortical ...
Yan eZhao, Yan eZhao, Zizhen eZhang, Xiuping eLiu, Colin eXiong, Zhongju eXiao, Jun eYan   +6 more
doaj   +1 more source

Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons

Frontiers in Molecular Neuroscience, 2022
GABAA receptors are ligand-gated ion channels, which are predominantly permeable for chloride. The neuronal K-Cl cotransporter KCC2 lowers the intraneuronal chloride concentration and thus plays an important role for GABA signaling. KCC2 loss-of-function
Tanja Herrmann, Melanie Gerth, Ralf Dittmann, Daniel Pensold, Martin Ungelenk, Lutz Liebmann, Christian A. Hübner   +6 more
doaj   +1 more source

Unbalance between Excitation and Inhibition in Phenylketonuria, a Genetic Metabolic Disease Associated with Autism [PDF]

, 2017
Phenylketonuria (PKU) is the most common genetic metabolic disease with a well-documented association with autism spectrum disorders. It is characterized by the deficiency of the phenylalanine hydroxylase activity, causing plasmatic hyperphenylalaninemia
Andolina, Diego, Colamartino, Marco, DE ANGELIS, Federica, DE JACO, Antonella, Favaloro, FLORES LIETTA, Fiori, Elena, Mango, Dalila, Nistico', ROBERT GIOVANNI, Pascucci, Tiziana   +8 more
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Functional maps of neocortical local circuitry

Frontiers in Neuroscience, 2007
This review aims to summarize data obtained with different techniques to provide a functional map of the local circuit connections made by neocortical neurones, a reference for those interested in cortical circuitry and the numerical information required
Alex M Thomson, Christophe Lamy
doaj   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source