Results 41 to 50 of about 276,610 (317)

Interplay between low threshold voltage-gated K+ channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis

Frontiers in Neural Circuits, 2014
Central auditory neurons that localize sound in horizontal space have specialized intrinsic and synaptic cellular mechanisms to tightly control the threshold and timing for action potential generation.
William eHamlet, William eHamlet, Yu-Wei eLiu, Zhengquang eTang, Yong eLu, Yong eLu   +5 more
doaj   +1 more source

Gain modulation of synaptic inputs by network state in auditory cortex in vivo [PDF]

, 2015
The cortical network recurrent circuitry generates spontaneous activity organized into Up (active) and Down (quiescent) states during slow-wave sleep or anesthesia.
Destexhe, Alain, Reig, Ramon, Sánchez Vives, María V., Vergara, Ramiro Oscar, Zerlaut, Yann   +4 more
core   +3 more sources

NMDA Currents Modulate the Synaptic Input–Output Functions of Neurons in the Dorsal Nucleus of the Lateral Lemniscus in Mongolian Gerbils [PDF]

, 2011
Neurons in the dorsal nucleus of the lateral lemniscus (DNLL) receive excitatory and inhibitory inputs from the superior olivary complex (SOC) and convey GABAergic inhibition to the contralateral DNLL and the inferior colliculi.
Felmy, Felix, Grothe, Benedikt, Meyer, Elisabeth M. M., Porres, Christian P.   +3 more
core   +1 more source

GABAB Receptors Augment TRPC3-Mediated Slow Excitatory Postsynaptic Current to Regulate Cerebellar Purkinje Neuron Response to Type-1 Metabotropic Glutamate Receptor Activation

Cells, 2018
During strong parallel fiber stimulation, glutamate released at parallel fiber-Purkinje cell synapses activates type-1 metabotropic glutamate receptor (mGluR1) to trigger a slow excitatory postsynaptic current (sEPSC) in cerebellar Purkinje neurons.
Jinbin Tian, Michael X. Zhu
doaj   +1 more source

Accumulation of Dense Core Vesicles in Hippocampal Synapses Following Chronic Inactivity. [PDF]

, 2018
The morphology and function of neuronal synapses are regulated by neural activity, as manifested in activity-dependent synapse maturation and various forms of synaptic plasticity.
Bi, Guo-Qiang, Lau, Pak-Ming, Liu, Yun-Tao, Tao, Chang-Lu, Zhou, Z Hong   +4 more
core   +2 more sources

Essential Functions of the Transcription Factor Npas4 in Neural Circuit Development, Plasticity, and Diseases

Frontiers in Neuroscience, 2020
Signaling from the synapse to nucleus is mediated by the integration and propagation of both membrane potential changes (postsynaptic potentials) and intracellular second messenger cascades.
Jian Fu, Ouyang Guo, Zhihang Zhen, Junli Zhen   +3 more
doaj   +1 more source

The positive allosteric modulator of NMDA receptors, GNE‐9278, blocks the ethanol‐induced decrease of excitability in developing retrosplenial cortex neurons from mice

Neuropsychopharmacology Reports, 2023
Binge‐like exposure to ethanol during the brain growth spurt triggers apoptotic neurodegeneration in multiple brain regions, including the retrosplenial cortex, a brain region that is part of the hippocampal‐diencephalic‐cingulate memory network. This is
Clark W. Bird, Carlos F. Valenzuela
doaj   +1 more source

Co-exposure of melamine and cyanuric acid as a risk factor for oxidative stress and energy metabolism: Adverse effects on hippocampal neuronal and synaptic function induced by excessive ROS production

Ecotoxicology and Environmental Safety, 2022
Melamine (MEL) and cyanuric acid (CA) alone have relatively low toxicity, but together they may cause serious damage to multiple organs, including the central nervous system, however, the underlying mechanism is unknown. This study aimed to determine and
Wei Sun, Xiao Chen, Yazi Mei, Xiaoliang Li, Yang Yang, Lei An   +5 more
doaj   +1 more source

Inhibitory or excitatory? Optogenetic interrogation of the functional roles of GABAergic interneurons in epileptogenesis

Journal of Biomedical Science, 2017
Alteration in the excitatory/inhibitory neuronal balance is believed to be the underlying mechanism of epileptogenesis. Based on this theory, GABAergic interneurons are regarded as the primary inhibitory neurons, whose failure of action permits ...
Hui Ye, Stephanie Kaszuba
doaj   +1 more source

The energy demand of fast neuronal network oscillations: insights from brain slice preparations

Frontiers in Pharmacology, 2012
Fast neuronal network oscillations in the gamma range (30-100 Hz) in the cerebral cortex have been implicated in higher cognitive functions such as sensual perception, working memory, and, perhaps, consciousness. However, little is known about the energy
Oliver eKann
doaj   +1 more source