Results 41 to 50 of about 521,946 (359)

Membrane-derived phospholipids control synaptic neurotransmission and plasticity. [PDF]

PLoS Biology, 2015
Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however, the molecular signals controlling synaptic dynamics have been poorly understood.
Victoria García-Morales, Fernando Montero, David González-Forero, Guillermo Rodríguez-Bey, Laura Gómez-Pérez, María Jesús Medialdea-Wandossell, Germán Domínguez-Vías, José Manuel García-Verdugo, Bernardo Moreno-López   +8 more
doaj   +1 more source

How feedback inhibition shapes spike-timing-dependent plasticity and its implications for recent Schizophrenia models [PDF]

, 2011
It has been shown that plasticity is not a fixed property but, in fact, changes depending on the location of the synapse on the neuron and/or changes of biophysical parameters.
Aihara, Akbarian, Andreasen, Angulo, Beasley, Bernd Porr, Bi, Bower, Christoph Kolodziejski, Clopath, De Schutter, De Schutter, Egerton, Feinberg, Florentin Wörgötter, Freund, Guidotti, Hebb, Iglesias, Jolivet, Kehrer, Klopf, Koch, Lewis, Lindskog, Lisman, Lynsey McCabe, Magee, Markram, Morris, O’Mann, Paolo di Prodi, Paz, Pierri, Porr, Porr, Ragland, Rapoport, Rubin, Saudargiene, Shinoda, Somogyi, Straub, Tamosiunaite, Tamosiunaite, Tamosiunaite, Traub, Ulrich, Voegtlin, Yang, Zaitsev   +50 more
core   +1 more source

Nucleus Reuniens Afferents in Hippocampus Modulate CA1 Network Function via Monosynaptic Excitation and Polysynaptic Inhibition

Frontiers in Cellular Neuroscience, 2021
The thalamic midline nucleus reuniens modulates hippocampal CA1 and subiculum function via dense projections to the stratum lacunosum-moleculare (SLM). Previously, anatomical data has shown that reuniens inputs in the SLM form synapses with dendrites of ...
Priyodarshan Goswamee, Elizabeth Leggett, A. Rory McQuiston   +2 more
doaj   +1 more source

Single dendrite-targeting interneurons generate branch-specific inhibition.

Frontiers in Neural Circuits, 2014
Microcircuits composed of dendrite-targeting inhibitory interneurons and pyramidal cells are fundamental elements of cortical networks, however, the impact of individual interneurons on pyramidal dendrites is unclear.
Caleb eStokes, Corinne eTeeter, Jeffry eIsaacson   +2 more
doaj   +1 more source

Interplay between low threshold voltage-gated K+ channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis

Frontiers in Neural Circuits, 2014
Central auditory neurons that localize sound in horizontal space have specialized intrinsic and synaptic cellular mechanisms to tightly control the threshold and timing for action potential generation.
William eHamlet, William eHamlet, Yu-Wei eLiu, Zhengquang eTang, Yong eLu, Yong eLu   +5 more
doaj   +1 more source

Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits [PDF]

Scientific Reports 8, 2221 (2018), 2018
Fluorescent nanodiamonds (FND) are carbon-based nanomaterials that can efficiently incorporate optically active photoluminescent centers such as the nitrogen-vacancy complex, thus making them promising candidates as optical biolabels and drug-delivery agents. FNDs exhibit bright fluorescence without photobleaching combined with high uptake rate and low
arxiv   +1 more source

Unbalance between Excitation and Inhibition in Phenylketonuria, a Genetic Metabolic Disease Associated with Autism [PDF]

, 2017
Phenylketonuria (PKU) is the most common genetic metabolic disease with a well-documented association with autism spectrum disorders. It is characterized by the deficiency of the phenylalanine hydroxylase activity, causing plasmatic hyperphenylalaninemia
Andolina, Diego, Colamartino, Marco, DE ANGELIS, Federica, DE JACO, Antonella, Favaloro, FLORES LIETTA, Fiori, Elena, Mango, Dalila, Nistico', ROBERT GIOVANNI, Pascucci, Tiziana   +8 more
core   +2 more sources

Postsynaptic activity of inhibitory neurons evokes hemodynamic fMRI responses

NeuroImage, 2021
Functional MRI responses are localized to the synaptic sites of evoked inhibitory neurons, but it is unknown whether, or by what mechanisms, these neurons initiate functional hyperemia.
Alexander John Poplawsky, Bistra Iordanova, Alberto L. Vazquez, Seong-Gi Kim, Mitsuhiro Fukuda   +4 more
doaj  

Brain injury impairs working memory and prefrontal circuit function

Frontiers in Neurology, 2015
More than 2.5 million Americans suffer a traumatic brain injury (TBI) each year. Even mild to moderate traumatic brain injury causes long-lasting neurological effects.
Colin James Smith, Colin James Smith, Guoxiang eXiong, Jaclynn eElkind, Brendan James Putnam, Akiva eCohen   +5 more
doaj   +1 more source

Disinhibition of hippocampal CA3 neurons induced by suppression of an adenosine A1 receptor-mediated inhibitory tonus: Pre- and postsynaptic components [PDF]

, 1993
Intracellular recordings were performed on hippocampal CA3 neuronsin vitro to investigate the inhibitory tonus generated by endogenously produced adenosine in this brain region.
Alzheimer, Alzheimer, Alzheimer, Alzheimer, Andreasen, Arai, Ault, Ault, B. Sutor, Bauer, Beavo, Beavo, Ben-Ari, Bruns, Bruns, C. Alzheimer, Chamberlin, Daly, Dragunow, Dragunow, Dunwiddie, Dunwiddie, Dunwiddie, Fredholm, G. Ten Bruggencate, Gerber, Greene, Greene, Haas, Hablitz, Hablitz, Jackisch, Johnston, Linden, Linden, Llinás, Lohse, Madison, Malenka, Meghji, Miles, Moraidis, Nicholson, Pockett, Prestwich, Prince, Scholz, Schubert, Schubert, Smellie, Smellie, Smith, Snyder, Snyder, Sutor, Tanaka, Thompson, Thompson, Van Calker, Williams, Zetterström   +60 more
core   +1 more source