Results 61 to 70 of about 276,610 (317)

Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]

, 2014
Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J, Hare, Emma B, Lozano, Reymundo   +2 more
core   +1 more source

Synaptic actions of amyotrophic-lateral-sclerosis-associated G85R-SOD1 in the squid giant synapse [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Song, Y.
Song, Yuyu
core   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]

, 2017
The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
core   +1 more source

Enhanced Switching Performance in Single‐Crystalline PbTiO3 Ferroelectric Memristors for Replicating Synaptic Plasticity

Advanced Functional Materials, EarlyView.
This study demonstrated single‐crystalline PbTiO3‐based memristors with atomically sharp interfaces, well‐ordered lattices, and minimal lattice mismatch. The devices exhibited an ON/OFF ratio exceeding 105, high stability, and rich resistance‐state modulation.
Haining Li, Zhiqiang Liao, Risa Kataoka, Md Sarker Shamim, Takeshi Kijima, Hiroyasu Yamahara, Hitoshi Tabata, Munetoshi Seki   +7 more
wiley   +1 more source

Depolarizing effect of neocortical chandelier neurons

Frontiers in Neural Circuits, 2009
Chandelier (or axo-axonic) cells are one of the most distinctive types of GABAergic interneurons in the cortex. Although they have traditionally been considered inhibitory neurons, data from rat and human neocortical preparations suggest that chandelier ...
Alan Woodruff, Qing Xu, Stewart A Anderson, Rafael Yuste   +3 more
doaj   +1 more source

A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum

Molecular Autism, 2020
Background DLG2, also known as postsynaptic density protein-93 (PSD-93) or chapsyn-110, is an excitatory postsynaptic scaffolding protein that interacts with synaptic surface receptors and signaling molecules.
Taesun Yoo, Sun-Gyun Kim, Soo Hyun Yang, Hyun Kim, Eunjoon Kim, Soo Young Kim   +5 more
doaj   +1 more source

Dynamical principles in neuroscience [PDF]

, 2006
Dynamical modeling of neural systems and brain functions has a history of success over the last half century. This includes, for example, the explanation and prediction of some features of neural rhythmic behaviors.
Abarbanel, H. D. I., Abarbanel, H. D. I., Abeles, M., Abeles, M., Adrian, E. D., Allen I. Selverston, Amit, D., Amit, D. J., Andronov, A., Andronov, A., Andronov, A. A., Arbib, M. A., Arnold, V., Ashby, W. R., Baird, B., Bartos, M., Bartos, M., Bi, G., Bliss, T. V., Bondarenko, V., Borda, J. C., Canavier, C., Chay, T., Chklovskii, D. B., Cohen, M. A., Crevier, D., Cymbalyuk, G., de Nó, R. L., deCharms, R., Diwadkar, V. A., Duda, R., Elson, R. C., Fano, R. M., Fatt, P., Freeman, W., Freeman, W., Fuhrmann, G., Gallager, R. G., Gavrilov, N., Gerstner, W., Glass, L., Goroff, D., Grossberg, S., Guckenheimer, J., Hatsopoulos, N., Hebb, R., Henry D. I. Abarbanel, Hodgkin, A. L., Hopfield, J., Ichinohe, N., Ince, D., Izhikevich, E., Jones, S. R., Kandel, E. R., Kaplan, D., Katz, B., Kim, U., Kimpo, R. R., Koch, C., Konishi, M., Kuramoto, Y., Kuznetsov, Y., Landau, L. D., Lapicque, L., Lashley, K., Levi, R., Lindner, B., Lotka, A. J., Malkov, V., Maravall, M., Marder, E., Mikhail I. Rabinovich, Nicholls, J. G., Nowotny, T., Oscarsson, O., Ott, E., O’Reilly, R., Pablo Varona, Panchin, Y., Pikovsky, A., Poincaré, A., Poincaré, H., Prinz, A., Prinz, A. A., Rabinovich, M., Ramirez, J., Reinagel, P., Rosenblatt, F., Rowe, D., Saari, G., Segundo, J. P., Segundo, J. P., Senseman, D. M., Seung, H. S., Shadlen, M. N., Shepherd, G., Simmers A. J., Singer, W., Stein, S. G., Strogatz, S. H., Szekely, G., Szücs, A., Szücs, A., Szücs, A., Tsuda, I., Turrigiano, G. G., Varona, P., Volterra, V., Wang, X.-J., Wilson, H. R., Zhigulin, V. P.   +110 more
core   +2 more sources

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source