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Inhibitory receptors as targets for cancer immunotherapy [PDF]
European Journal of Immunology, 2015 Inhibitory receptors expressed on T cells control immune responses while limiting autoimmunity. However, tumors can hijack these “checkpoints” for protection from immune attack. Tumor‐specific T cells that exhibit an exhausted, unresponsive phenotype express high levels of inhibitory receptors including CTLA4, PD1, and LAG3, among others.
Dario Vignali +2 more
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Science, 2000
With the detailed description and analysis of several inhibitory receptor systems on lymphoid and myeloid cells, a central paradigm has emerged in which the pairing of activation and inhibition is necessary to initiate, amplify, and then terminate immune responses.
J V, Ravetch, L L, Lanier
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With the detailed description and analysis of several inhibitory receptor systems on lymphoid and myeloid cells, a central paradigm has emerged in which the pairing of activation and inhibition is necessary to initiate, amplify, and then terminate immune responses.
J V, Ravetch, L L, Lanier
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Modulators of the Inhibitory Glycine Receptor
ACS Chemical Neuroscience, 2020The inhibitory glycine receptor is a member of the Cys-loop superfamily of ligand-gated ion channels. It is the principal mediator of rapid synaptic inhibition in the spinal cord and brainstem and plays an important role in the modulation of higher brain functions including vision, hearing, and pain signaling. Glycine receptor function is controlled by
Ulrike Breitinger, Hans-Georg Breitinger
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The inhibitory neuronal glycine receptor
BioEssays, 1994AbstractGlycine is a major inhibitory neurotransmitter in the spinal cord and in the brain stem, where it acts by activating a chloride conductance. The postsynaptic glycine receptor has been purified and contains two transmembrane subunits of 48 kDa (α) and 58 kDa (β), and a peripheral membrane protein of 93 kDa.
C, Béchade, C, Sur, A, Triller
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NMDA receptor function in inhibitory neurons
Neuropharmacology, 2021N-methyl-d-aspartate receptors (NMDARs) are present in the majority of brain circuits and play a key role in synaptic information transfer and synaptic plasticity. A key element of many brain circuits are inhibitory GABAergic interneurons that in themselves show diverse and cell-type-specific NMDAR expression and function.
Sam A. Booker, David J.A. Wyllie
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The regulation of lymphocyte activation by inhibitory receptors
Current Opinion in Immunology, 2004The ability of activating immune recognition receptors on lymphocytes to regulate cellular activation and function can be profoundly altered by co-stimulation with inhibitory receptors. Inhibitory receptors, such as the MHC-recognizing inhibitory receptors expressed on NK cells and subpopulations of activated T cells, can fully block the generation of ...
Paul J Leibson
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Inhibitory receptors, ITIM sequences and phosphatases
Current Opinion in Immunology, 1997A diverse group of inhibitory receptors, including FcgammaRII, killer cell inhibitory receptors, and B22, shares an immunoreceptor tyrosine-based inhibition motif (ITIM). Recent studies have shown that this motif, when phosphorylated on tyrosine, forms a docking site for the Src homology 2 recognition domains of the protein tyrosine phosphatase SHP-1 ...
Jay C Unkeless, J C Unkeless
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Inhibitory receptors and allergy
Current Opinion in Immunology, 2002Recent studies of the major cell types involved in the initiation and progression of allergic inflammation have revealed that they express an unexpectedly large number of surface receptors that inhibit the release of proinflammatory mediators from mast cells and basophils in vitro. Moreover, analyses of animals deficient in some of these receptors, for
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Inhibitory neuropeptide receptors on macrophages
Microbes and Infection, 2001The immune response, both in innate and adaptive immunity, is controlled at several levels, including signaling from the central nervous system. Neuropeptides released within the lymphoid organs modulate the immune response, either as stimulators or inhibitors.
D, Ganea, M, Delgado
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Inhibitory Neurosteroids and the GABAA Receptor
2015γ-Aminobutyric acid type A receptors (GABAARs) are vital proteins that are engaged in regulating neural circuit activity in the central nervous system. Their effectiveness in this task is dependent on the extent of receptor modulation by naturally occurring ligands that are released in the brain.
Sandra, Seljeset +2 more
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