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Inhibitory glutamate receptor channels
Molecular Neurobiology, 1996Inhibitory glutamate receptors (IGluRs) are a family of ion channel proteins closely related to ionotropic glycine and gamma-aminobutyric acid (GABA) receptors; They are gated directly by glutamate; the open channel is permeable to chloride and sometimes potassium. Physiologically and pharmacologically, IGluRs most closely resemble GABA receptors; they
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Stimulatory and inhibitory receptor interactions in xenotransplantation
Current Opinion in Organ Transplantation, 2010Cellular human antipig immune responses are increasingly recognized as an important barrier to successful clinical xenotransplantation. This review addresses the role of monocytes/macrophages, natural killer (NK) cells, and T cells in xenograft rejection. We focus on the receptor-ligand interactions that regulate the responses of these cells to porcine
Annegret, Plege, Reinhard, Schwinzer
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Structure and Expression of Inhibitory Glycine Receptors
1991Signal transmission at chemical synapses involves specific receptors that transduce neurotransmitter binding into alterations of membrane potential. Receptors containing integral ion channels mediate rapid (in the ≤ msec range) transduction events, whereas receptors activating G-protein coupled channels operate at slower time scales (in the msec to sec
H. Betz +13 more
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The Unique Inhibitory IgG Receptor--FcγRIIb
Protein & Peptide Letters, 2018FcγRIIb is the only inhibitory IgG receptor, which is divided into three subtypes of FcγRIIb1, FcγRIIb2 and FcγRIIb3. It is mainly responsible for the immune balance in vivo by cross-linking with the activated receptor to intracellular transduction inhibitory signals, and it plays an important biological role in the negative regulation of innate ...
Zhenzhen, Xu +6 more
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Molecular biology of inhibitory amino acid receptors
Molecular Neurobiology, 1987Biochemical approaches to neurotransmitter receptors have been extensively exploited in recent years. With the introduction of radiolabeled analogs of transmitters or drugs thought to act at these transmitter receptors, it has become possible to directly study the binding sites of neurotransmitter receptors and draw conclusions as to the relative order
R S, Duman +3 more
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Structure and function of inhibitory glycine receptors
Quarterly Reviews of Biophysics, 1992Ion transport by peptide channels has been the major theme in the work of the late P. Läuger. His theoretical and experimental approaches provided the basis for a deeper understanding of pore-mediated ion permeation through biological membranes. This review on a ligand–gated ion channel protein from the mammalian brain is dedicated to the memory of ...
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Activating and Inhibitory NK Cell Receptors
1998Karre and colleagues observed that tumors lacking H-2 molecules were more susceptible to NK cell-mediated lysis than tumors expressing class I and proposed a unique mechanism of immune surveillance for ‘missing self’ (1). The molecular mechanism responsible for this phenomenon has been defined by the identification of membrane receptors on NK cells ...
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ADP Receptors: Inhibitory Strategies for Antiplatelet Therapy
Drug News & Perspectives, 2006The interaction of adenosine-5'-diphosphate (ADP) with its platelet receptors (P2Y(1) and P2Y(12)) plays a very important role in thrombogenesis. The thienopyridine ticlopidine was the first specific antagonist of the platelet P2Y(12) ADP receptor to be tested in randomized clinical trials for the prevention of arterial thrombotic events.
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The Leukemia Inhibitory Factor and Its Receptor
1993Publisher Summary This chapter focuses on the leukemia inhibitory factor (LIF) and its receptor that exemplifies many features of cytokine biology. The gene encoding LIF has been cloned and its product characterized extensively; LIF binds to receptors on responsive cells with high and low affinity and the molecular basis for the two types of ...
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