Results 181 to 190 of about 15,268 (219)
Some of the next articles are maybe not open access.
iNKT-Cell Responses to Glycolipids
Critical Reviews in Immunology, 2005Invariant natural killer T (iNKT) cells are an unusual group of T lymphocytes that recognize glycolipid antigens presented by the major histocompatibility complex class I-related protein CD1d. Because iNKT cells play a regulatory role in the immune system, they are attractive targets for immunotherapy.
Vrajesh V, Parekh +2 more
openaire +2 more sources
The interaction between iNKT cells and B cells
Journal of Leukocyte Biology, 2021AbstractInvariant natural killer T cells (iNKTs) bridge the innate immunity with the adaptive immunity and their interaction with B cells has been extensively studied. Here, we give a complete overview of these two cells, from their mechanism of interaction to clinical prospects and existing problems.
Tong, Zhu +9 more
openaire +2 more sources
iNKT Cells in Allergic Disease
2007Recent studies indicate that invariant TCR+ CD1d-restricted natural killer T (iNKT) cells play an important role in regulating the development of asthma and allergy. iNKT cells can function to skew adaptive immunity toward Th2 responses, or can act directly as effector cells at mucosal surfaces in diseases such as ulcerative colitis and bronchial ...
E H, Meyer, R H, DeKruyff, D T, Umetsu
openaire +2 more sources
iNKT cells need UTX-tra demethylation
Nature Immunology, 2017The epigenetic regulation of gene expression by the histone demethylase UTX is central to the development of invariant natural killer cells.
S Harsha, Krovi, Laurent, Gapin
openaire +2 more sources
Clinical Immunology, 2019
Invariant natural killer T cells (iNKT) produce large amounts of different cytokines which can influence differentiation, polarization and activation of immune cells, particularly NK and T cells. iNKT have been shown to suppress GvHD and promote anti-tumor and anti-pathogen immunity.
Mohammad, Fereidouni +2 more
openaire +2 more sources
Invariant natural killer T cells (iNKT) produce large amounts of different cytokines which can influence differentiation, polarization and activation of immune cells, particularly NK and T cells. iNKT have been shown to suppress GvHD and promote anti-tumor and anti-pathogen immunity.
Mohammad, Fereidouni +2 more
openaire +2 more sources
GVHD protection? ThiNK iNKT cells
Blood, 2012In this issue of Blood , Rubio et al report that posttransplant invariant NKT (iNKT) cell recovery is inversely correlated with the risk of developing GVHD after stem cell transplantation ...
openaire +2 more sources
Expansion of Human iNKT Cells Ex Vivo
2021Invariant natural killer T (iNKT) cells are credited with antitumor activity by preclinical studies and clinical trials. Efficient expansion of iNKT cells ex vivo is essential for their translational usage. The culturing procedure described here provides an optimized method for ex vivo expansion of iNKT cells using recombinant human IL-15 (rhIL-15) and
Jing, Wang, Chen, Zhao, Jianqing, Xu
openaire +2 more sources
Science Signaling, 2012
Invariant natural killer T cells produce anti-inflammatory cytokines in the adipose tissue and protect against diet-induced obesity.
openaire +1 more source
Invariant natural killer T cells produce anti-inflammatory cytokines in the adipose tissue and protect against diet-induced obesity.
openaire +1 more source
Genetic Analysis of iNKT Cell Development and Function
2021Natural killer T (NKT) cells are among the immediate and early responding immune cells and are important players in autoimmune diseases and tumor immunity. This unique subset of T cells shares properties of natural killer cells and T cells. Proper identification and characterization of NKT cell subsets is essential to understand the function and ...
Julie, Sahler +5 more
openaire +2 more sources
2008
The complexity of the immune system requires mechanisms, cellular and molecular, that coordinate early innate immune responses to those of late adaptive immune responses. One type of immune cell that is able to mediate this bridge between innate immunity and adaptive immunity is the invariant natural killer T (iNKT) cell. In recent years, much research
Dalam Ly, Terry L. Delovitch
openaire +1 more source
The complexity of the immune system requires mechanisms, cellular and molecular, that coordinate early innate immune responses to those of late adaptive immune responses. One type of immune cell that is able to mediate this bridge between innate immunity and adaptive immunity is the invariant natural killer T (iNKT) cell. In recent years, much research
Dalam Ly, Terry L. Delovitch
openaire +1 more source