Results 191 to 200 of about 15,268 (219)

Unraveling tumor-specific iNKT cell plasticity

The Journal of Immunology, 2020
Abstract Despite the overall success of T-cell based immunotherapies, the number of patients that benefit is still lower than expected. Invariant Natural Killer T cells (iNKTs) offer an alternative and appealing therapeutic platform owing to their intrinsic features and independence from MHC restriction.
Filippo Cortesi, Leonie Konczalla, Tabea M Sturmheit, Francesco Siracusa, Nicola Gagliani   +4 more
openaire   +1 more source

Kidins220 promotes thymic iNKT cell development by reducing TCR signals, but enhances TCR signals in splenic iNKT cells

SSRN Electronic Journal, 2022
AbstractThe stepwise development of thymic invariant natural killer T (iNKT) cells is controlled by the TCR signal strength. The scaffold protein Kinase D interacting substrate of 220 kDa (Kidins220) binds to the TCR regulating TCR signaling. T cell-specific Kidins220 knock-out (T-KO) mice contain severely decreased iNKT numbers.
Laurenz A. Herr, Gina J. Fiala, Anna-Maria Schaffer, Katrin Raute, Rubí M.-H. Velasco Cárdenas, Jonas F. Hummel, Karolina Ebert, Yakup Tanriver, Susana Minguet, Wolfgang W. Schamel   +9 more
openaire   +1 more source

Expression of functional GPR35 in human iNKT cells

Biochemical and Biophysical Research Communications, 2010
The aim of this study was to examine the expression of G protein-coupled receptor (GPR)35 in human invariant natural killer T (iNKT) cells and to determine the functional effects induced by selective activation of this receptor. RT-PCR analysis showed that both human iNKT cells and resting PBMC expressed GPR35; GPR35 protein resulted mostly localized ...
Silvia Fallarini
exaly   +3 more sources

iNKT Cells: Innate Lymphocytes with a Diverse Response

Critical Reviews in Immunology, 2014
It is now established that natural killer T (NKT) cells can influence adaptive immune responses by producing vast amounts of cytokines. Different subsets of NKT cells with distinctive functional characteristics regarding cytokine production have been described.
Monteiro, Marta, Graca, Luis
openaire   +3 more sources

A nano-engager for iNKT cells in cancer

Nature Cancer, 2020
Invariant natural killer T cells (iNKT cells) are innate-like CD1d-restricted T cells that have NK cell–like properties and bear an invariant T cell receptor (iTCR). iNKT cells have shown potential for cancer immunotherapy. A study now shows that stabilization of the iTCR–CD1d complex via a single-chain bi-specific antibody stimulates iNKT cell ...
Mark A. Exley, Thomas Gensollen, Richard S. Blumberg   +2 more
openaire   +2 more sources

The iNKT cell ligand α-GalCer prevents murine septic shock by inducing IL10-producing iNKT and B cells

Frontiers in Immunology
Introductionα-galactosylceramide (α-GalCer), a prototypical agonist of invariant natural killer T (iNKT) cells, stimulates iNKT cells to produce various cytokines such as IFNγ and IL4. Moreover, repeated α-GalCer treatment can cause protective or pathogenic outcomes in various immune-mediated diseases.
Yun Hoo Park, Sung Won Lee, Tae-Cheol Kim   +2 more
exaly   +4 more sources

AIRE deficiency leads to impaired iNKT cell development

Journal of Autoimmunity, 2010
Autoimmune Polyendocrine Syndrome type I (APS I) is caused by mutations in the Autoimmune Regulator gene (AIRE), and results in the immunological destruction of endocrine organs. Herein we have characterized the CD1d-restricted invariant NKT cells (iNKT) and NK cells in APS I patients and Aire(-/-) mice, two cell populations known to play a role in the
Emma, Lindh, Eleftheria, Rosmaraki, Louise, Berg, Hanna, Brauner, Mikael C I, Karlsson, Leena, Peltonen, Petter, Höglund, Ola, Winqvist   +7 more
openaire   +2 more sources

iNKT cells do a fat lot of good

Nature Immunology, 2016
Altered signaling via the T cell antigen receptor (TCR) promotes an adipose-tissue-like phenotype in invariant natural killer cells (iNKT cells) during thymic development and causes selective enrichment for iNKT cells in adipose tissues.
Jayati, Mookerjee-Basu, Dietmar J, Kappes   +1 more
openaire   +2 more sources

iNKT cells circulate

Nature Immunology, 2022
openaire   +2 more sources

CAR-iNKT cell therapy: mechanisms, advantages, and challenges

Current Research in Translational Medicine
In recent years, chimeric antigen receptor (CAR) T-cell therapy has emerged as a groundbreaking approach in cancer immunotherapy. Particularly in hematologic malignancies, such as B-cell acute lymphoblastic leukemia (B-ALL), B cell lymphomas and multiple myeloma.
Zixuan Wang, Guangji Zhang
openaire   +2 more sources