Results 51 to 60 of about 229,257 (276)

Video_1_Cytotoxic innate intraepithelial lymphocytes control early stages of Cryptosporidium infection.mp4

, 2023
BackgroundIntraepithelial lymphocytes (IELs) are the first immune cells to contact and fight intestinal pathogens such as Cryptosporidium, a widespread parasite which infects the gut epithelium. IFN-γ producing CD4+ T IELs provide an efficient and a long-
Bertrand Meresse (759244), Fatima Hariss, Mohamad Ezzedine, Marie Delbeke (6162704), Gabriela Certad, Fatima Hariss (16936980), Gabriela Certad (111449), Marie Delbeke, Bertrand Meresse, Karine Guyot (111399), Mohamad Ezzedine (16936986), Pauline Zarnitzky, Pauline Zarnitzky (16936983), Karine Guyot   +13 more
core   +1 more source

NK Cell Development in Times of Innate Lymphoid Cell Diversity

Frontiers in Immunology, 2020
After being described in the 1970s as cytotoxic cells that do not require MHC-dependent pre-activation, natural killer (NK) cells remained the sole member of innate lymphocytes for decades until lymphoid tissue-inducer cells in the 1990s and helper-like ...
Vladislava Stokic-Trtica, Vladislava Stokic-Trtica, Andreas Diefenbach, Andreas Diefenbach, Andreas Diefenbach, Christoph S. N. Klose   +5 more
doaj   +1 more source

Lipopolysaccharides-Induced Suppression of Innate-Like B Cell Apoptosis Is Enhanced by CpG Oligodeoxynucleotide and Requires Toll-Like Receptors 2 and 4. [PDF]

PLoS ONE, 2016
Innate-like B lymphocytes play an important role in innate immunity in periodontal disease through Toll-like receptor (TLR) signaling. However, it is unknown how innate-like B cell apoptosis is affected by the periodontal infection-associated innate ...
Xiaoqian Yu, Yuhua Wang, Jiang Lin, Yang Hu, Toshihisa Kawai, Martin A Taubman, Xiaozhe Han   +6 more
doaj   +1 more source

The Emerging Role of Innate Lymphoid Cells (ILCs) and Alarmins in Celiac Disease: An Update on Pathophysiological Insights, Potential Use as Disease Biomarkers, and Therapeutic Implications

Cells, 2023
Celiac disease (CD) is an intestinal disease that develops in genetically predisposed individuals and is triggered by the ingestion of gluten. CD was considered a Th1-disease.
Angela Rizzi, Mario Di Gioacchino, Luca Gammeri, Riccardo Inchingolo, Raffaella Chini, Francesca Santilli, Eleonora Nucera, Sebastiano Gangemi   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

"Corrigendum: Ontogeny of innate T lymphocytes – some innate lymphocytes are more innate than others"

, 2014
Innate lymphocytes have recently received a lot of attention. However, there are different ideas about the definition of what is innate in lymphocytes. Lymphocytes without V(D)J-rearranged antigen receptors are now termed innate lymphoid cells (ILCs) and
David eVermijlen, Vermijlen, David, David Vermijlen, Immo ePrinz, Immo Prinz, Prinz, Immo   +5 more
core   +1 more source

DataSheet_1_Cytotoxic innate intraepithelial lymphocytes control early stages of Cryptosporidium infection.docx

, 2023
BackgroundIntraepithelial lymphocytes (IELs) are the first immune cells to contact and fight intestinal pathogens such as Cryptosporidium, a widespread parasite which infects the gut epithelium. IFN-γ producing CD4+ T IELs provide an efficient and a long-
Bertrand Meresse (759244), Fatima Hariss (16936980), Gabriela Certad (111449), Marie Delbeke (6162704), Karine Guyot (111399), Mohamad Ezzedine (16936986), Pauline Zarnitzky (16936983)   +6 more
core   +1 more source

Activated TLR2/4-positive T cells boost cell exhaustion during lepromatous leprosy infection via PD-1 upregulation

Heliyon, 2022
The most important stage in activating an appropriate immune response during an infection is pathogen detection. Pattern recognition receptors (PRRs) are innate sensors used for pathogen detection that mould and link the innate and adaptive immune ...
Soumi Sadhu, Sanjay Kumar, Dipendra Kumar Mitra, Beenu Joshi   +3 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source