Results 41 to 50 of about 229,257 (276)

Innate Lymphocytes and Malaria – Players or Spectators?

, 2019
Malaria remains an important global disease. Despite significant advances over the past decade in reducing disease morbidity and mortality, new measures are needed if malaria is to be eliminated.
Ng, Susanna S, Engwerda, Christian R, Susanna S. Ng, Christian R. Engwerda   +3 more
core   +1 more source

Expression of genes related to anti-inflammatory pathways are modified among farmers' children [PDF]

, 2014
The hygiene hypothesis states that children exposed to higher loads of microbes such as farmers' children suffer less from allergies later in life. Several immunological mechanisms underpinning the hygiene hypothesis have been proposed such as a shift in
Loeliger, Susanne, Roduit, Caroline; https://orcid.org/, van Hage, Marianne, Göran Pershagen, Sennhauser, Felix, Lauener, Roger P., Remo Frei, Marianne van Hage (91132), IRAS RATIA2, Felix Sennhauser, Susanne Loeliger (254440), von Mutius, Erika, Erika von Mutius (105805), Caroline Roduit (254441), Gert Doekes (397763), as part of the Parsifal study team,, Christian Bieli (531936), Waser, Marco, Cezmi A Akdis, Christian Bieli, Mutius, Erika von, Annika Scheynius, Roduit, Caroline, Riedler, Josef, Göran Pershagen (147977), LS IRAS EEPI GRA (Gezh.risico-analyse), Braun-Fahrländer, Charlotte, Remo Frei (254425), Roger P. Lauener (254451), Caroline Roduit, Akdis, Cezmi A, Risk Assessment of Toxic and Immunomodulatory Agents, Lauener, Roger P, Cezmi A. Akdis (187641), Akdis, Cezmi A., Marco Waser, Pershagen, Göran, Erika von Mutius, Doekes, Gert, Gert Doekes, Felix Sennhauser (531938), Josef Riedler, Susanne Loeliger, Charlotte Braun-Fahrländer, Hage, Marianne van, Frei, Remo, Scheynius, Annika, as part of the PARSIFAL study team, Roger P Lauener, Annika Scheynius (31954), Josef Riedler (194501), Charlotte Braun-Fahrländer (18248), Bieli, Christian, Marianne van Hage, Marco Waser (531937)   +54 more
core   +1 more source

Dysregulation of Systemic Immunity in Aging and Dementia

Frontiers in Cellular Neuroscience, 2021
Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and contribute to neurodegenerative pathology. Although microglia have been the focus of work linking neuroinflammation and associated dementias like Alzheimer’s ...
Jenny Lutshumba, Jenny Lutshumba, Jenny Lutshumba, Barbara S. Nikolajczyk, Barbara S. Nikolajczyk, Adam D. Bachstetter, Adam D. Bachstetter, Adam D. Bachstetter   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice

eLife, 2017
Adaptive autoimmunity is restrained by controlling population sizes and pathogenicity of harmful clones, while innate destruction is controlled at effector phase.
Fei Tang, Peng Zhang, Peiying Ye, Christopher A Lazarski, Qi Wu, Ingrid L Bergin, Timothy P Bender, Michael N Hall, Ya Cui, Liguo Zhang, Taijiao Jiang, Yang Liu, Pan Zheng   +12 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Role of Innate-like Lymphocytes in the Pathogenesis of Community Acquired Pneumonia [PDF]

, 2018
Abstract Background Mucosal-associated invariant T (MAIT) cells and Vδ2 + γδ T cells are anti-bacterial innate-like lymphocytes (ILLs) that are enriched in blood and mucosa.
Hannaway, RF, Wang, X, Schneider, M, Slow, S, Schofield, MR, Morgan, X, Murdoch, DR, Ussher, JE   +7 more
openaire   +1 more source

Early interferon-γ production in human lymphocyte subsets in response to nontyphoidal Salmonella demonstrates inherent capacity in innate cells.

PLoS ONE, 2010
BackgroundNontyphoidal Salmonellae frequently cause life-threatening bacteremia in sub-Saharan Africa. Young children and HIV-infected adults are particularly susceptible.
Tonney S Nyirenda, Anna E Seeley, Wilson L Mandala, Mark T Drayson, Calman A MacLennan   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source