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Frontiers in AgingCD38 is a transmembrane glycoprotein involved in NAD+ metabolism, calcium signaling, and immune cell activation. Its role in the inflammatory response has been studied extensively in innate immune cells; however, its contribution to the activation of ...
Wendolaine Santiago-Cruz +6 more
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The role of innate lymphocytes in regulating brain and cognitive function
Neurobiology of Disease, 2023 Mounting evidence indicates complex interaction between the immune system and the nervous system, challenging the traditional view about the immune privilege of the brain. Innate lymphoid cells (ILCs) and innate-like T cells are unique families of immune
Youwen Si +3 more
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Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes [PDF]
The Journal of Immunology, 2020 Abstract The self-renewal ability is a unique property of fetal-derived innate-like B-1a lymphocytes, which survive and function without being replenished by bone marrow (BM) progenitors. However, the mechanism by which IgM-secreting mature B-1a lymphocytes self-renew is poorly understood.
Michihiro Kobayashi +12 more
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Frontiers in Immunology, 2021 Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, in which autoreactive T and B cells play important roles. Other lymphocytes such as NK cells and innate-like T cells appear to be involved as well.
Josefine Ruder +7 more
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Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions
Viruses, 2022 Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVID-19). Although
Wan Rong Sia +6 more
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Frontiers in Immunology, 2022 Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate–adaptive immune response independently.
Jiang-Hui Meng +8 more
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Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells
Life Science Alliance, 2022 Single-cell RNA sequencing of porcine ileal lymphocytes reveals similarities to human cells and discovery of porcine intestinal innate lymphoid cells. Lymphocytes can heavily influence intestinal health, but resolving intestinal lymphocyte function is ...
Jayne E Wiarda +4 more
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Close encounters of lymphoid cells and bacteria
Frontiers in Immunology, 2016 During infections, the first reaction of the host against microbial pathogens is carried out by innate immune cells, which recognize conserved structures on pathogens, called pathogen-associated molecular patterns (PAMPs).
Aranzazu Cruz-Adalia, Esteban Veiga
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Tissue-Resident Innate and Innate-Like Lymphocyte Responses to Viral Infection [PDF]
Viruses, 2019 Infection is restrained by the concerted activation of tissue-resident and circulating immune cells. Recent discoveries have demonstrated that tissue-resident lymphocyte subsets, comprised of innate lymphoid cells (ILCs) and unconventional T cells, have vital roles in the initiation of primary antiviral responses.
Andrew D. Hildreth +1 more
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Tissue-resident lymphocytes: sentinel of the transformed tissue
Journal for ImmunoTherapy of Cancer, 2017 Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized.
Saïda Dadi, Ming O. Li
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