Results 11 to 20 of about 219,914 (245)

NFAT2 regulates generation of innate-like CD8+ T lymphocytes and CD8+ T lymphocytes responses [PDF]

Frontiers in Immunology, 2016
NFAT2 null mutant mice die in utero of cardiac failure, precluding analysis of the role of NFAT2 in lymphocyte responses. Only the NFAT2-/-/Rag-1-/- chimeric mice model gave insight into the role of NFAT2 transcription factor in T lymphocyte development,
Emilia Pachulec, Vanessa Neitzke-Montinelli, Joao P.B. Viola   +2 more
doaj   +3 more sources

Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease [PDF]

Respiratory Research, 2017
Background Based on the phenotypic and functional characteristics unconventional T-lymphocytes such as invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells link the innate and adaptive immune responses.
Mariann Szabó, Veronika Sárosi, Zoltán Balikó, Kornélia Bodó, Nelli Farkas, Tímea Berki, Péter Engelmann   +6 more
doaj   +3 more sources

Innate-like lymphocytes in intestinal infections. [PDF]

Curr Opin Infect Dis, 2015
The mechanisms of immunity against intestinal pathogens are not well understood. Innate-like lymphocytes are a group of recently discovered cells that do not fit into either side of the historical innate-adaptive classification. They are enriched in the intestinal mucosa and participate in gut homeostasis and defense against infections.
Bennett MS, Round JL, Leung DT.
europepmc   +4 more sources

The in-betweeners: MAIT cells join the innate-like lymphocytes gang. [PDF]

J Exp Med, 2014
![Figure][1] Insight from David Margulies Recent studies of mucosal-associated invariant T (MAIT) cells indicate that they respond to a range of pathogen-derived vitamin metabolites presented at the cell surface by the evolutionarily conserved and nonpolymorphic MHC-related class I ...
Margulies DH.
europepmc   +4 more sources

Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes

, 2023
Abstract Natural intraepithelial T lymphocytes (T-IELs) are innate-like, intestine-resident T cells essential for gut homeostasis. These cells express self-reactive T cell antigen receptors (TCRs) due to thymic agonist selection, but they do not cause autoimmunity. The mechanism underlying natural T-IELs tolerance in the gut is unclear.
Chawla AS, Watt HJ, Schattgen SA, Skariah N, Saha I, Warrick KA, Ogawa M, Strid J, Lamoliatte F, Copland A, Pryde S, Knatko E, Rasmussen KD, Kikuchi K, Thomas PG, Pasare C, Bending D, Swamy M.   +17 more
europepmc   +3 more sources

Mechanisms of activation of innate-like intraepithelial T lymphocytes [PDF]

Mucosal Immunology, 2020
Intraepithelial T lymphocytes (T-IEL) contain subsets of innate-like T cells that evoke innate and adaptive immune responses to provide rapid protection at epithelial barrier sites. In the intestine, T-IEL express variable T cell antigen receptors (TCR), with unknown antigen specificities.
Vandereyken, Maud, James, Olivia, Swamy, Mahima   +2 more
openaire   +3 more sources

Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions

Viruses, 2022
Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the causative agent of coronavirus disease 2019 (COVID-19). Although
Wan Rong Sia, Yichao Zheng, Fei Han, Shiwei Chen, Shaohua Ma, Lin-Fa Wang, Edwin Leeansyah   +6 more
doaj   +1 more source

Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes [PDF]

The Journal of Immunology, 2020
Abstract The self-renewal ability is a unique property of fetal-derived innate-like B-1a lymphocytes, which survive and function without being replenished by bone marrow (BM) progenitors. However, the mechanism by which IgM-secreting mature B-1a lymphocytes self-renew is poorly understood.
Michihiro Kobayashi, Yang Lin, Akansha Mishra, Chris Shelly, Rui Gao, Colton W Reeh, Paul Zhiping Wang, Rongwen Xi, Yunlong Liu, Pamela Wenzel, Eliver Ghosn, Yan Liu, Momoko Yoshimoto   +12 more
openaire   +2 more sources

NK Cells and Innate-Like T Cells After Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Frontiers in Immunology, 2021
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, in which autoreactive T and B cells play important roles. Other lymphocytes such as NK cells and innate-like T cells appear to be involved as well.
Josefine Ruder, Jordan Rex, Simon Obahor, María José Docampo, Antonia M. S. Müller, Urs Schanz, Ilijas Jelcic, Roland Martin   +7 more
doaj   +1 more source

Cytotoxic innate intraepithelial lymphocytes control early stages of Cryptosporidium infection

Frontiers in Immunology, 2023
BackgroundIntraepithelial lymphocytes (IELs) are the first immune cells to contact and fight intestinal pathogens such as Cryptosporidium, a widespread parasite which infects the gut epithelium. IFN-γ producing CD4+ T IELs provide an efficient and a long-
Fatima Hariss, Marie Delbeke, Karine Guyot, Pauline Zarnitzky, Mohamad Ezzedine, Gabriela Certad, Gabriela Certad, Bertrand Meresse   +7 more
doaj   +1 more source