Results 11 to 20 of about 229,257 (276)
NFAT2 regulates generation of innate-like CD8+ T lymphocytes and CD8+ T lymphocytes responses [PDF]
Frontiers in Immunology, 2016 NFAT2 null mutant mice die in utero of cardiac failure, precluding analysis of the role of NFAT2 in lymphocyte responses. Only the NFAT2-/-/Rag-1-/- chimeric mice model gave insight into the role of NFAT2 transcription factor in T lymphocyte development,
Emilia Pachulec +2 more
doaj +4 more sources
Mechanisms of activation of innate-like intraepithelial T lymphocytes [PDF]
Mucosal Immunology, 2020 Intraepithelial T lymphocytes (T-IEL) contain subsets of innate-like T cells that evoke innate and adaptive immune responses to provide rapid protection at epithelial barrier sites. In the intestine, T-IEL express variable T cell antigen receptors (TCR),
Vandereyken, Maud +2 more
core +5 more sources
Interactions between the microbiota and innate and innate-like lymphocytes
Journal of Leukocyte Biology, 2017 The microbiota, which consists of commensal bacteria, fungi, and viruses, limits the colonization of pathogens at barrier tissues and promotes immune homeostasis. The latter is accomplished through the induction and regulation of both innate and adaptive
Michael G Constantinides
core +3 more sources
Cytotoxic innate intraepithelial lymphocytes control early stages of Cryptosporidium infection [PDF]
Frontiers in Immunology, 2023 BackgroundIntraepithelial lymphocytes (IELs) are the first immune cells to contact and fight intestinal pathogens such as Cryptosporidium, a widespread parasite which infects the gut epithelium. IFN-γ producing CD4+ T IELs provide an efficient and a long-
Fatima Hariss +7 more
doaj +2 more sources
Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages
Frontiers in Immunology, 2018 Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family
Chun Chou, Ming O. Li
doaj +2 more sources
Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease [PDF]
Respiratory Research, 2017 Background Based on the phenotypic and functional characteristics unconventional T-lymphocytes such as invariant natural killer T (iNKT) cells and mucosal-associated invariant T (MAIT) cells link the innate and adaptive immune responses.
Mariann Szabó +6 more
doaj +3 more sources
Innate-like lymphocytes in intestinal infections. [PDF]
Curr Opin Infect Dis, 2015 The mechanisms of immunity against intestinal pathogens are not well understood. Innate-like lymphocytes are a group of recently discovered cells that do not fit into either side of the historical innate-adaptive classification. They are enriched in the intestinal mucosa and participate in gut homeostasis and defense against infections.
Bennett MS, Round JL, Leung DT.
europepmc +4 more sources
Genetics and functions of innate-like lymphocyte subsets
, 2007 The immune system contains three different branches: innate immunity, adaptive immunity and innate-like lymphocytes that share properties both with the innate and adaptive immune cells.
Rolf, Julia
core +3 more sources
The in-betweeners: MAIT cells join the innate-like lymphocytes gang. [PDF]
J Exp Med, 2014 ![Figure][1] Insight from David Margulies Recent studies of mucosal-associated invariant T (MAIT) cells indicate that they respond to a range of pathogen-derived vitamin metabolites presented at the cell surface by the evolutionarily conserved and nonpolymorphic MHC-related class I ...
Margulies DH.
europepmc +4 more sources
Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes
, 2023 Abstract Natural intraepithelial T lymphocytes (T-IELs) are innate-like, intestine-resident T cells essential for gut homeostasis. These cells express self-reactive T cell antigen receptors (TCRs) due to thymic agonist selection, but they do not cause autoimmunity. The mechanism underlying natural T-IELs tolerance in the gut is unclear.
Chawla AS +17 more
europepmc +3 more sources