Results 261 to 270 of about 560,484 (284)
A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells
Cell Stem Cell, 2016 The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during hematopoietic development are unclear. Using an irreversible lineage-tracing model, we identify a definitive
Anna E Beaudin +2 more
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Programme of self-reactive innate-like T cell-mediated cancer immunity
Nature, 2022Cellular transformation induces phenotypically diverse populations of tumour-infiltrating T cells1-5, and immune checkpoint blockade therapies preferentially target T cells that recognize cancer cell neoantigens6,7. Yet, how other classes of tumour-infiltrating T cells contribute to cancer immunosurveillance remains elusive.
Chun Chou +24 more
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Invariant natural killer T cells: innate‐like T cells with potent immunomodulatory activities
Tissue Antigens, 2009AbstractInvariant natural killer T (iNKT) cells are a subset of T lymphocytes that react with glycolipid antigens presented by the major histocompatibility complex class I‐related glycoprotein CD1d. Although iNKT cells express an antigen‐specific receptor of the adaptive immune system, they behave more like cells of the innate immune system. A hallmark
L, Wu +3 more
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Metabolic control of innate-like T cells
Nature Reviews ImmunologyImmunometabolism, the intersection of cellular metabolism and immune function, has revolutionized our understanding of T cell biology. Changes in cellular metabolism help guide the development of thymocytes and the transition of T cells from naive to effector, memory and tissue-resident states.
Thomas Riffelmacher +2 more
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Fates of Commensal Specific, Innate-like CD8+ T cells in the Gut
The Journal of Immunology, 2023Abstract Barrier tissues such as the skin and gut are host to a variety of microbes collectively termed the microbiota. To maintain host homeostasis, sufficient exposure to the microbiota is necessary, however, diseases such as Inflammatory Bowel Disease (IBD), have been described as occurring amidst breakdown in the normal communication
Taylor K Farley +3 more
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Sympathetic regulation of skin microbiota-induced innate-like T cells
The Journal of Immunology, 2023Abstract Recent discoveries in microbiota-mediated neuroimmune crosstalk highlight how co-evolved systems collaboratively facilitate host fitness. However, in the skin – the largest and outermost protective barrier – little is known about the role of microbiota in neuro-immune regulation.
Indira N Rao +6 more
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A Self-reactive Innate-like T-cell Program Was Identified in Cancer Immunity
Cancer Discovery, 2022Abstract A class of αβ T-cell receptor–positive, FCER1G-expressing T cells with high cytotoxic potential was identified.
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PTEN checkMAITs type-17 innate-like T cells
Nature Cell Biology, 2022Nikolaos Patsoukis +1 more
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Innate and Innate-Like Cells: The Future of Chimeric Antigen Receptor (CAR) Cell Therapy
Trends in Pharmacological Sciences, 2021Diana Cortes-Selva +2 more
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The Changing Immune Landscape of Innate-like T Cells and Innate Cells Throughout Life
ABSTRACT Spectral flow cytometry is an advanced immunological tool that enables comprehensive analysis of the immune system by simultaneously comparing innate and adaptive immune cells. Here, using a 40-colour antibody panel we advance our knowledge of innate and innate-like T cells by investigating chemokine ...Marziyeh Taheri +8 more
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