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Resident Innate Immune Cells in the Cornea [PDF]
Frontiers in Immunology, 2021 The cornea is a special interface between the internal ocular tissue and the external environment that provides a powerful chemical, physical, and biological barrier against the invasion of harmful substances and pathogenic microbes. This protective effect is determined by the unique anatomical structure and cellular composition of the cornea ...
Zhijie Li, Li Zhijie
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Immunological Reviews, 2000
Summary: Mast cells are known to be the main effector cells in the elicitation of the IgE‐mediated allergic response. The specific location of mast cells within tissues that interface the external environment, and the extent of their functional capacity, including the ability to phagocytose and to produce and secrete a wide spectrum of mediators, have ...
Y A, Mekori, D D, Metcalfe
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Summary: Mast cells are known to be the main effector cells in the elicitation of the IgE‐mediated allergic response. The specific location of mast cells within tissues that interface the external environment, and the extent of their functional capacity, including the ability to phagocytose and to produce and secrete a wide spectrum of mediators, have ...
Y A, Mekori, D D, Metcalfe
openaire +2 more sources
Trends in Immunology, 2013
Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated.
Julie, Deckers +2 more
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Asthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated.
Julie, Deckers +2 more
openaire +2 more sources
Current Opinion in Immunology, 2005
NK cells have an important role in innate immune responses, particularly in anti-viral immunity. Recent studies have revealed a molecular basis for NK cell recognition of virus-infected cells, implicating the activating KIR and Ly49 receptors and NKG2D in this process.
Jessica A, Hamerman +2 more
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NK cells have an important role in innate immune responses, particularly in anti-viral immunity. Recent studies have revealed a molecular basis for NK cell recognition of virus-infected cells, implicating the activating KIR and Ly49 receptors and NKG2D in this process.
Jessica A, Hamerman +2 more
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Innate immune cells in the tumor microenvironment
Cancer Cell, 2021The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies.
Li, Ming O +10 more
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Journal of Allergy and Clinical Immunology, 2004
Mast cells have been most extensively studied in their traditional role as an early effector cell of allergic disease. However, in the majority of individuals, it might be the role of this cell as a sentinel in host defense that is most important.
Jean S, Marshall, Dunia M, Jawdat
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Mast cells have been most extensively studied in their traditional role as an early effector cell of allergic disease. However, in the majority of individuals, it might be the role of this cell as a sentinel in host defense that is most important.
Jean S, Marshall, Dunia M, Jawdat
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Innate immune cells in reproduction
Journal of Obstetrics and Gynaecology Research, 2018AbstractFetomaternal immune tolerance is required to prevent fetal rejection during pregnancy; simultaneously, the maternal immune system must also protect the fetus from harmful endogenous and exogenous antigens, including those associated with viral and bacterial infections.
Yasuyuki Negishi +3 more
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Innate Immune System Cells in Atherosclerosis
Archives of Medical Research, 2014Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by innate and adaptive immune system involvement. A key component of atherosclerotic plaque inflammation is the persistence of different innate immune cell types including mast cells, neutrophils, natural killer cells, monocytes, macrophages and dendritic cells ...
Luis Chávez-Sánchez
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Mast cells and basophils in innate immunity
Seminars in Immunology, 1998Mast cells and basophils are primarily associated with the pathophysiology of allergic diseases. Considering that these cells have been preserved through evolution they must serve a valuable function. Intrinsically, mast cells are ideally placed and well endowed with inflammatory mediators to play a critical role in immune surveillance.
S N, Abraham, M, Arock
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