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Innate immune cells in the tumor microenvironment
Cancer Cell, 2021The tumor immune microenvironment (TIME) is a complex ecosystem that contains adaptive and innate immune cells that have tumor-promoting and anti-tumor effects. There is still much to learn about the diversity, plasticity, and functions of innate immune cells in the TIME and their roles in determining the response to immunotherapies.
Li, Ming O +10 more
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Mast cells and basophils in innate immunity
Seminars in Immunology, 1998Mast cells and basophils are primarily associated with the pathophysiology of allergic diseases. Considering that these cells have been preserved through evolution they must serve a valuable function. Intrinsically, mast cells are ideally placed and well endowed with inflammatory mediators to play a critical role in immune surveillance.
S N, Abraham, M, Arock
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Innate immune cells in the adipose tissue
Reviews in Endocrine and Metabolic Disorders, 2018Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like anti-inflammatory macrophages and innate lymphoid cells 2, contribute to the maintenance of metabolic homeostasis within the AT.
Chung, K.-J. +3 more
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Trends in Immunology, 2011
When faced with an invasion of microbes or non-infectious tissue damage, surrounding cells send for help. Leukocytes respond to these signals and infiltrate the injured tissue to help fight infection and cleanup damage. The idea that innate immune cells are mobilized early in the inflammatory response is not new.
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When faced with an invasion of microbes or non-infectious tissue damage, surrounding cells send for help. Leukocytes respond to these signals and infiltrate the injured tissue to help fight infection and cleanup damage. The idea that innate immune cells are mobilized early in the inflammatory response is not new.
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Paneth cells and the innate immune response
Current Opinion in Gastroenterology, 2006To review recently published studies presenting novel and relevant information on Paneth cells and their function.Paneth cells are secretory epithelial cells which are predominantly found in the small-intestinal crypts of Lieberkühn. Their most abundant products are alpha-defensins, which are endogenous antibiotics with activity against gram-negative ...
Jan, Wehkamp, Eduard F, Stange
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Innate Lymphoid Cells in Immunity and Disease
2013The family of innate lymphoid cells (ILCs) comprises of natural killer (NK) cells, Rorγt-dependent ILCs (lymphoid tissue inducer (LTi) cells, ILC22, and ILC17), and type 2 ILCs. Apart from a common requirement for inhibitor of DNA binding 2 (Id2) expression and common γ-chain (γc) signaling, the differentiation of ILC populations is regulated by ...
You Yi, Hwang, Andrew N J, McKenzie
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Immunity without innate lymphoid cells
Nature Immunology, 2016A cohort of immunodeficient children lead near-normal lives after bone marrow transplantation, despite a profound deficiency of innate lymphoid cells (ILCs).
Weinkove, Robert +2 more
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The Paneth cell and the innate immune response
Current Opinion in Gastroenterology, 2004Innate immune defense of the small intestine is mediated in part by antimicrobial peptides and proteins secreted by Paneth cells, epithelial cells positioned at the base of the crypts of Lieberkuhn. Recent studies have yielded better understanding of the role that Paneth cells may play in host defense.
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Mast cells as sentinels of innate immunity
Current Opinion in Immunology, 1999Mast cells are widely regarded as important effector cells in immune responses associated with Th2 cells and IgE. Recent work shows that they can also contribute significantly to the expression of innate immunity; furthermore, survival in a model of acute bacterial infection that is dependent on complement and mast cells can be greatly enhanced by long-
S J, Galli, M, Maurer, C S, Lantz
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Innate lymphoid cells at the crossroads of innate and adaptive immunity
Hepatology, 2022Firouzeh, Korangy +2 more
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