Results 71 to 80 of about 303,423 (293)

The Emerging Role of Pattern Recognition Receptors in the Pathogenesis of Malaria

Vaccines, 2018
Despite a global effort to develop an effective vaccine, malaria is still a significant health problem. Much of the pathology of malaria is immune mediated. This suggests that host immune responses have to be finely regulated.
Parisa Kalantari
doaj   +1 more source

Immune-mediated mechanisms influencing the efficacy of anticancer therapies [PDF]

, 2015
Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not only determined by their direct effects on cancer cells but also by off ...
Acharyya, Affara, Ahn, Ahn, Albanesi, Alizadeh, Anders, Andreu, Apetoh, Azab, Balachandran, Bald, Begg, Borg, Bos, Broz, Bruchard, Burnette, Casares, Cavnar, Chabner, Chao, Chung, Ciampricotti, Clynes, Coffelt, Cooper, Dankort, De Palma, De Palma, De Palma, De Palma, De Palma, de Visser, de Visser, Demaria, DeNardo, DeNardo, Deng, Deng, Derksen, Devaud, DeVita, Di Maio, Di Mitri, Diaz-Montero, Dijkgraaf, Dirkx, Dranoff, Du, DuPage, DuPage, Engelhardt, Ferrari de Andrade, Finke, Fischer, Francia, Fridlender, Gabrilovich, Gabrusiewicz, Ganesan, Garbe, Germano, Ghiringhelli, Ghiringhelli, Goodman, Grugan, Guerin, Guerriero, Gupta, Guy, Guy, Hagerling, Hamid, Han, Hanahan, Hanahan, Hanna, Hannesdottir, Herbst, Highfill, Ho, Hodi, Houthuijzen, Huang, Imai, Jiang, Kanterman, Karin E. de Visser, Kioi, Kitamura, Klug, Knight, Ko, Kodumudi, Kowanetz, Koya, Kozin, Krumbhaar, Landsberg, Le, Ledford, Lee, Lesterhuis, Li, Liauw, Lin, Lin, Liu, Lutsiak, Ma, Ma, Manning, Mantovani, Maroulakou, Matsumura, Mattarollo, Mazzieri, Minard-Colin, Mitchem, Mokyr, Muller, Muller, Munoz, Murdoch, Nakasone, Nefedova, Noh, North, Noy, Ojalvo, Olive, Pahler, Pander, Pardoll, Park, Paulus, Pienta, Pollizzi, Porembka, Powell, Powles, Priceman, Pucci, Pyonteck, Qian, Quail, Rakhra, Ramakrishnan, Reits, Ries, Robert, Robert, Robert, Rolny, Ruffell, Sahu, Sandhu, Savage, Schioppa, Seth B. Coffelt, Sevko, Shevchenko, Shojaei, Shojaei, Shojaei, Shree, Shrimali, Simpson, Singh, Singh, Singh, Sistigu, Smith, Snyder, Sommer, Srivastava, Stanley, Stockmann, Straussman, Suzuki, Suzuki, Swierczak, Takeshima, Talmadge, Taskinen, Terme, Toso, Tumeh, Ugel, Vanneman, Verbrugge, Vincent, Walter, Wang, Wang, Welford, Wilmott, Wu, Wu, Xu, Xue, Yang, Youn, Zhang, Zhang, Zhu   +206 more
core   +1 more source

and the innate immune system

International Journal of Medical Microbiology, 2005
Since its discovery, Helicobacter pylori surprises us by its ability for life-long chronic persistence, proliferation, and probably active adaptation in the unfavourable niche of the human stomach, without being eliminated by the defence systems of the human body. This minireview highlights recent developments about the interaction of H.
Sae Kyung Lee, Christine Josenhans, Christine Josenhans   +2 more
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Neuro-immune communication in C. elegans defense against pathogen infection

Current Research in Immunology, 2021
The innate immune system is a complex collection of physical barriers and physiological defense responses to internal and external environmental assaults. Recent studies in the model organism Caenorhabditis elegans have highlighted how the nervous system
Phillip Wibisono, Jingru Sun
doaj  

The microglial "activation" continuum: from innate to adaptive responses [PDF]

, 2005
Microglia are innate immune cells of myeloid origin that take up residence in the central nervous system (CNS) during embryogenesis. While classically regarded as macrophage-like cells, it is becoming increasingly clear that reactive microglia play more ...
Nikolic, Veljko, Tan, Jun, Town, Terrence   +2 more
core   +3 more sources

Control of adaptive immunity by the innate immune system [PDF]

Nature Immunology, 2015
Microbial infections are recognized by the innate immune system both to elicit immediate defense and to generate long-lasting adaptive immunity. To detect and respond to vastly different groups of pathogens, the innate immune system uses several recognition systems that rely on sensing common structural and functional features associated with different
Ruslan Medzhitov, Akiko Iwasaki
openaire   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Hold Breath: Autonomic Neural Regulation of Innate Immunity to Defend Against SARS-CoV-2 Infection

Frontiers in Microbiology, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel member of the genus of betacoronavirus, which caused a pandemic of coronavirus disease 2019 (COVID-19) worldwide.
Changle Wang, Yan Zhao, Hongxiu Qiao, Zhiyun Gao, Jing Yang, Xia Chuai   +5 more
doaj   +1 more source

DAMPs and PDT-mediated photo-oxidative stress: exploring the unknown [PDF]

, 2011
Damage-associated molecular patterns (DAMPs) or cell death associated molecular patterns (CDAMPs) are a subset of endogenous intracellular molecules that are normally hidden within living cells but become either passively released by primary and ...
Agostinis, Patrizia, Garg, Abhishek D, Krysko, Dmitri, Vandenabeele, Peter   +3 more
core   +1 more source